dbPTM

LARP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LARP1_MOUSE
UniProt AC	Q6ZQ58
Protein Name	La-related protein 1
Gene Name	Larp1
Organism	Mus musculus (Mouse).
Sequence Length	1072
Subcellular Localization	Cytoplasm . Cytoplasmic granule . Colocalizes with RPTOR and PABPC1 in cytoplasmic granules that resemble stress granules.
Protein Description	RNA-binding protein that promotes translation of specific classes of mRNAs downstream of the mTORC1 complex. Associates with the mRNA 5'cap in an MTOR-dependent manner and associates with mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding for ribosomal proteins and several components of the translation machinery. Associates with actively translating ribosomes via interaction with PABPC1/PABP and stimulates translation of mRNAs containing a 5'TOP, thereby regulating cell growth and proliferation. Positively regulates the replication of dengue virus (DENV)..
Protein Sequence	MATQVEPLLPAGAPLLQAEEHGLARKKPAPDAQAESGPGDGGGEPDGGVRRPRPACARPGRDGAERESPRPPAAAEAPAGSDGEDGGRRDFVEAPPPKVNPWTKHAPPPAAVNGQPPPEPSAPAKVVRAAAPKPRKGSKVGDFGDAVNWPTPGEIAHKSVQPQSHKPQPARKLPPKKDMKEQEKGDGSDSKESPKTKSDESGEEKNGDEDCQRGGQKKKGSKHKWVPLQIDMKPEVPREKLASRPTRPQEPRHTPAVRGEMKGSEPATYMPVSVAPPTPAWQPETKVEPAWHDQDETSSVKSDGAGGARASFRGRGRGRGRGRGRGRGGTRTHFDYQFGYRKFDGTEGPRTHKYMNNITYYFDNVSSNEIYSMDQELLKDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEMVEEKVRRREEPEKWPLPGPPIVDYSQTDFSQLLNCPEFVPRQHYQKETESAPGSPRAVTPVPTKTEEVSNLKTLPKGLSASLPDLDSESWIEVKKRPRPSPARPKKPEEPRFSHPTALPQQLPSQQLMSKDQDEQEELDFLFDEEMEQMDGRKNTFTAWSEEDSDYEIDDRDVNKILIVTQTPPYMRRHPGGDRTGNHTSRAKMSAELAKVINDGLFYYEQDLWTEKFEPEYSQIKQEVENFKKVNMISREQFDTLTPEPPVDPNQEVPPGPPRFQQVPTDALANKLFGAPEPSTIARSLPTTVPESPNYRNARTPRTPRTPQLKDSSQTPRFYPVVKEGRTLDAKMPRKRKTRHSSNPPLESHVGWVMDSREHRPRTASISSSPSEGTPAVGSYGCTPQSLPKFQHPSHELLKENGFTQHVYHKYRRRCLNERKRLGIGQSQEMNTLFRFWSFFLRDHFNKKMYEEFKQLALEDAKEGYRYGLECLFRYYSYGLEKKFRLDIFKDFQEETVKDYEAGQLYGLEKFWAFLKYSKAKNLDIDPKLQEYLGKFRRLEDFRVDPPMGEEGNHKRHPVVAGGSGEGRKRCPSQSSSRPATGISQPPTTPTGQATREDAKWTSQHSDTLTLRK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATQVEPLL ------CCCCCCCCC	20.31	-
36	Phosphorylation	APDAQAESGPGDGGG CCHHHCCCCCCCCCC	53.99	23684622
68	Phosphorylation	RDGAERESPRPPAAA CCCCCCCCCCCCCHH	32.22	25521595
81	Phosphorylation	AAEAPAGSDGEDGGR HHCCCCCCCCCCCCC	44.54	27087446
138	Phosphorylation	APKPRKGSKVGDFGD CCCCCCCCCCCCCCC	27.48	21082442
188	Phosphorylation	EQEKGDGSDSKESPK HHHCCCCCCCCCCCC	43.37	25266776
190	Phosphorylation	EKGDGSDSKESPKTK HCCCCCCCCCCCCCC	39.77	25266776
193	Phosphorylation	DGSDSKESPKTKSDE CCCCCCCCCCCCCCC	35.12	25266776
196	Phosphorylation	DSKESPKTKSDESGE CCCCCCCCCCCCCCC	38.88	27087446
198	Phosphorylation	KESPKTKSDESGEEK CCCCCCCCCCCCCCC	52.41	27087446
201	Phosphorylation	PKTKSDESGEEKNGD CCCCCCCCCCCCCCC	57.40	27087446
213	Methylation	NGDEDCQRGGQKKKG CCCHHHHCCCCCCCC	58.50	24129315
243	Phosphorylation	VPREKLASRPTRPQE CCHHHHCCCCCCCCC	49.59	19854140
278	Phosphorylation	PVSVAPPTPAWQPET CCCCCCCCCCCCCCC	25.28	30352176
297	Phosphorylation	AWHDQDETSSVKSDG CCCCCCCCCCCCCCC	34.29	27087446
298	Phosphorylation	WHDQDETSSVKSDGA CCCCCCCCCCCCCCC	30.96	27742792
299	Phosphorylation	HDQDETSSVKSDGAG CCCCCCCCCCCCCCC	40.77	27087446
302	Phosphorylation	DETSSVKSDGAGGAR CCCCCCCCCCCCCCC	38.84	27087446
330	Ubiquitination	RGRGRGGTRTHFDYQ CCCCCCCCCCCEEEE	34.91	27667366
336	Phosphorylation	GTRTHFDYQFGYRKF CCCCCEEEECCCEEC	12.56	22499769
340	Phosphorylation	HFDYQFGYRKFDGTE CEEEECCCEECCCCC	16.36	22499769
351	Phosphorylation	DGTEGPRTHKYMNNI CCCCCCCCCCCCCCE	26.34	-
359	Phosphorylation	HKYMNNITYYFDNVS CCCCCCEEEEECCCC	17.81	22345495
360	Phosphorylation	KYMNNITYYFDNVSS CCCCCEEEEECCCCH	9.80	22345495
361	Phosphorylation	YMNNITYYFDNVSSN CCCCEEEEECCCCHH	8.87	22345495
366	Phosphorylation	TYYFDNVSSNEIYSM EEEECCCCHHHEECC	33.43	22345495
367	Phosphorylation	YYFDNVSSNEIYSMD EEECCCCHHHEECCC	33.91	22345495
371	Phosphorylation	NVSSNEIYSMDQELL CCCHHHEECCCHHHH	7.55	22345495
372	Phosphorylation	VSSNEIYSMDQELLK CCHHHEECCCHHHHH	22.88	22345495
381	Phosphorylation	DQELLKDYIKRQIEY CHHHHHHHHHHHHHH	13.52	22345495
426	Phosphorylation	FHRVQALTTDISLIF HHHHHHHHCCHHHHH	25.99	25159016
427	Phosphorylation	HRVQALTTDISLIFA HHHHHHHCCHHHHHH	31.99	25159016
430	Phosphorylation	QALTTDISLIFAALK HHHHCCHHHHHHHHC	20.44	25159016
437	Ubiquitination	SLIFAALKDSKVVEM HHHHHHHCCCHHHHH	56.05	-
488	Phosphorylation	EFVPRQHYQKETESA CCCCHHHHHHCCCCC	16.97	25777480
492	Phosphorylation	RQHYQKETESAPGSP HHHHHHCCCCCCCCC	42.13	27742792
494	Phosphorylation	HYQKETESAPGSPRA HHHHCCCCCCCCCCC	47.38	25521595
498	Phosphorylation	ETESAPGSPRAVTPV CCCCCCCCCCCCCCC	15.34	27087446
503	Phosphorylation	PGSPRAVTPVPTKTE CCCCCCCCCCCCCCH	19.99	26824392
507	Phosphorylation	RAVTPVPTKTEEVSN CCCCCCCCCCHHCCC	51.32	27087446
508	Ubiquitination	AVTPVPTKTEEVSNL CCCCCCCCCHHCCCC	48.12	27667366
509	Phosphorylation	VTPVPTKTEEVSNLK CCCCCCCCHHCCCCC	39.60	25619855
513	Phosphorylation	PTKTEEVSNLKTLPK CCCCHHCCCCCCCCC	39.46	25619855
517	Phosphorylation	EEVSNLKTLPKGLSA HHCCCCCCCCCCCCC	52.00	25266776
523	Phosphorylation	KTLPKGLSASLPDLD CCCCCCCCCCCCCCC	25.20	17203969
525	Phosphorylation	LPKGLSASLPDLDSE CCCCCCCCCCCCCCC	36.74	27087446
527	Ubiquitination	KGLSASLPDLDSESW CCCCCCCCCCCCCCC	37.31	27667366
531	Phosphorylation	ASLPDLDSESWIEVK CCCCCCCCCCCEEEC	40.61	25619855
533	Phosphorylation	LPDLDSESWIEVKKR CCCCCCCCCEEECCC	36.99	25619855
544	Phosphorylation	VKKRPRPSPARPKKP ECCCCCCCCCCCCCC	32.26	24899341
557	Phosphorylation	KPEEPRFSHPTALPQ CCCCCCCCCCCCCCC	29.81	26060331
560	Phosphorylation	EPRFSHPTALPQQLP CCCCCCCCCCCCCCC	35.09	-
568	Phosphorylation	ALPQQLPSQQLMSKD CCCCCCCHHHHCCCC	38.87	22324799
573	Phosphorylation	LPSQQLMSKDQDEQE CCHHHHCCCCHHHHH	41.49	22324799
599	Phosphorylation	QMDGRKNTFTAWSEE HCCCCCCCEEECCCC	25.95	25521595
601	Phosphorylation	DGRKNTFTAWSEEDS CCCCCCEEECCCCCC	25.77	24925903
604	Phosphorylation	KNTFTAWSEEDSDYE CCCEEECCCCCCCCC	28.75	24925903
608	Phosphorylation	TAWSEEDSDYEIDDR EECCCCCCCCCCCCC	45.42	24925903
610	Phosphorylation	WSEEDSDYEIDDRDV CCCCCCCCCCCCCCC	20.80	24925903
624	Phosphorylation	VNKILIVTQTPPYMR CCEEEEEECCCCCCC	21.52	24925903
626	Phosphorylation	KILIVTQTPPYMRRH EEEEEECCCCCCCCC	19.50	24925903
629	Phosphorylation	IVTQTPPYMRRHPGG EEECCCCCCCCCCCC	12.40	24925903
649	Phosphorylation	HTSRAKMSAELAKVI CHHHHHHHHHHHHHH	20.20	24759943
699	Phosphorylation	ISREQFDTLTPEPPV CCHHHHCCCCCCCCC	33.54	25619855
701	Phosphorylation	REQFDTLTPEPPVDP HHHHCCCCCCCCCCC	27.91	25521595
730	Ubiquitination	PTDALANKLFGAPEP CHHHHHHHHHCCCCC	39.32	-
730	Ubiquitination	PTDALANKLFGAPEP CHHHHHHHHHCCCCC	39.32	22790023
738	Phosphorylation	LFGAPEPSTIARSLP HHCCCCCCHHHHHCC	30.68	25266776
739	Phosphorylation	FGAPEPSTIARSLPT HCCCCCCHHHHHCCC	29.39	27087446
743	Phosphorylation	EPSTIARSLPTTVPE CCCHHHHHCCCCCCC	29.67	18388127
746	Phosphorylation	TIARSLPTTVPESPN HHHHHCCCCCCCCCC	45.80	24925903
747	Phosphorylation	IARSLPTTVPESPNY HHHHCCCCCCCCCCC	31.93	27087446
751	Phosphorylation	LPTTVPESPNYRNAR CCCCCCCCCCCCCCC	16.63	18388127
754	Phosphorylation	TVPESPNYRNARTPR CCCCCCCCCCCCCCC	14.50	24925903
759	Phosphorylation	PNYRNARTPRTPRTP CCCCCCCCCCCCCCC	18.08	26824392
762	Phosphorylation	RNARTPRTPRTPQLK CCCCCCCCCCCCCCC	20.51	26824392
765	Phosphorylation	RTPRTPRTPQLKDSS CCCCCCCCCCCCCCC	19.31	26824392
769	Ubiquitination	TPRTPQLKDSSQTPR CCCCCCCCCCCCCCC	50.76	-
771	Phosphorylation	RTPQLKDSSQTPRFY CCCCCCCCCCCCCCC	23.82	26643407
772	Phosphorylation	TPQLKDSSQTPRFYP CCCCCCCCCCCCCCC	48.48	26643407
774	Phosphorylation	QLKDSSQTPRFYPVV CCCCCCCCCCCCCCC	20.55	26643407
797	Phosphorylation	KMPRKRKTRHSSNPP CCCCCCCCCCCCCCC	37.33	25266776
800	Phosphorylation	RKRKTRHSSNPPLES CCCCCCCCCCCCCHH	28.64	23984901
801	Phosphorylation	KRKTRHSSNPPLESH CCCCCCCCCCCCHHH	47.43	26824392
807	Phosphorylation	SSNPPLESHVGWVMD CCCCCCHHHCEECCC	31.02	25159016
815	Phosphorylation	HVGWVMDSREHRPRT HCEECCCCCCCCCCC	22.82	26643407
822	Phosphorylation	SREHRPRTASISSSP CCCCCCCCCCCCCCC	27.69	24925903
824	Phosphorylation	EHRPRTASISSSPSE CCCCCCCCCCCCCCC	23.53	24925903
826	Phosphorylation	RPRTASISSSPSEGT CCCCCCCCCCCCCCC	23.44	25521595
827	Phosphorylation	PRTASISSSPSEGTP CCCCCCCCCCCCCCC	44.60	25521595
828	Phosphorylation	RTASISSSPSEGTPA CCCCCCCCCCCCCCC	26.17	24925903
830	Phosphorylation	ASISSSPSEGTPAVG CCCCCCCCCCCCCCC	51.08	25521595
833	Phosphorylation	SSSPSEGTPAVGSYG CCCCCCCCCCCCCCC	12.20	24925903
838	Phosphorylation	EGTPAVGSYGCTPQS CCCCCCCCCCCCCCC	16.26	24925903
839	Phosphorylation	GTPAVGSYGCTPQSL CCCCCCCCCCCCCCC	15.42	24925903
842	Phosphorylation	AVGSYGCTPQSLPKF CCCCCCCCCCCCCCC	21.72	24925903
845	Phosphorylation	SYGCTPQSLPKFQHP CCCCCCCCCCCCCCC	48.09	24925903
853	Phosphorylation	LPKFQHPSHELLKEN CCCCCCCCHHHHHHC	27.71	21183079
869	Acetylation	FTQHVYHKYRRRCLN CHHHHHHHHHHHHHH	23.82	-
994	Ubiquitination	KLQEYLGKFRRLEDF HHHHHHHHCCCHHHC	32.86	-
994	Acetylation	KLQEYLGKFRRLEDF HHHHHHHHCCCHHHC	32.86	-
994	Ubiquitination	KLQEYLGKFRRLEDF HHHHHHHHCCCHHHC	32.86	22790023
1023	Phosphorylation	HPVVAGGSGEGRKRC CCEECCCCCCCHHCC	32.52	25266776
1030	Glutathionylation	SGEGRKRCPSQSSSR CCCCHHCCCCCCCCC	4.22	24333276
1032	Phosphorylation	EGRKRCPSQSSSRPA CCHHCCCCCCCCCCC	46.44	27087446
1034	Phosphorylation	RKRCPSQSSSRPATG HHCCCCCCCCCCCCC	34.32	21082442
1035	Phosphorylation	KRCPSQSSSRPATGI HCCCCCCCCCCCCCC	23.80	25619855
1036	Phosphorylation	RCPSQSSSRPATGIS CCCCCCCCCCCCCCC	47.75	27087446
1040	Phosphorylation	QSSSRPATGISQPPT CCCCCCCCCCCCCCC	37.42	23684622
1043	Phosphorylation	SRPATGISQPPTTPT CCCCCCCCCCCCCCC	37.67	25619855
1047	Phosphorylation	TGISQPPTTPTGQAT CCCCCCCCCCCCCCC	52.68	26824392
1048	Phosphorylation	GISQPPTTPTGQATR CCCCCCCCCCCCCCH	25.32	26824392
1050	Phosphorylation	SQPPTTPTGQATRED CCCCCCCCCCCCHHH	39.57	25619855
1054	Phosphorylation	TTPTGQATREDAKWT CCCCCCCCHHHHHCC	27.06	25619855
1065	Phosphorylation	AKWTSQHSDTLTLRK HHCCCCCCCCEEECC	25.34	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
278	T	Phosphorylation	Kinase	MAPK1	P63085	GPS
743	S	Phosphorylation	Kinase	MTOR	Q9JLN9	PSP
751	S	Phosphorylation	Kinase	MAPK1	P63085	GPS
751	S	Phosphorylation	Kinase	MTOR	Q9JLN9	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LARP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LARP1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of LARP1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LARP1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-299; SER-302; THR-503;SER-525 AND SER-751, AND MASS SPECTROMETRY.	19131326 [Abstract]
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-604 AND SER-608, ANDMASS SPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81 AND SER-201, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Specific phosphopeptide enrichment with immobilized titanium ionaffinity chromatography adsorbent for phosphoproteome analysis."; Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.; J. Proteome Res. 7:3957-3967(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-503 AND SER-525, ANDMASS SPECTROMETRY.	18630941 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-604; SER-608; SER-751;SER-828 AND SER-1032, AND MASS SPECTROMETRY.	17242355 [Abstract]