LAMA2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LAMA2_MOUSE
• UniProt AC: Q60675
• Protein Name: Laminin subunit alpha-2
• Gene Name: Lama2
• Organism: Mus musculus (Mouse).
• Sequence Length: 3118
• Subcellular Localization: Secreted, extracellular space, extracellular matrix, basement membrane. Major component.
• Protein Description: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components..
• Protein Sequence: MPAATAGILLLLLLGTLEGSQTQRRQSQAHQQRGLFPAVLNLASNALITTNATCGEKGPEMYCKLVEHVPGQPVRNPQCRICNQNSSNPYQRHPITNAIDGKNTWWQSPSIKNGVEYHYVTITLDLQQVFQIAYVIVKAANSPRPGNWILERSLDDVEYKPWQYHAVTDTECLTLYNIYPRTGPPSYAKDDEVICTSFYSKIHPLENGEIHISLINGRPSADDPSPELLEFTSARYIRLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYYYSVKDISVGGMCICYGHARACPLDPATNKSRCECEHNTCGESCDRCCPGFHQKPWRAGTFLTKSECEACNCHGKAEECYYDETVASRNLSLNIHGKYIGGGVCINCTHNTAGINCETCVDGFFRPKGVSPNYPRPCQPCHCDPTGSLSEVCVKDEKYAQRGLKPGSCHCKTGFGGVNCDRCVRGYHGYPDCQPCNCSGLGSTNEDPCVGPCSCKENVEGEDCSRCKSGFFNLQEDNQKGCEECFCSGVSNRCQSSYWTYGNIQDMRGWYLTDLSGRIRMAPQLDNPDSPQQISISNSEARKSLLDGYYWSAPPPYLGNRLPAVGGQLSFTISYDLEEEEDDTEKILQLMIIFEGNDLRISTAYKEVYLEPSEEHIEEVSLKEEAFTIHGTNLPVTRKDFMIVLTNLERVLMQITYNLGMDAIFRLSSVNLESAVPYPTDRRIATDVEVCQCPPGYSGSSCETCWPRHRRVNGTIFGGICEPCQCFAHAEACDDITGECLNCKDHTGGPYCNECLPGFYGDPTRGSPEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDECPIGYTGPRCERCAEGYFGQPSIPGGSCQPCQCNDNLDYSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVNAKNCQPCRCNINGSFSEICHTRTGQCECRPNVQGRHCDECKPETFGLQLGRGCLPCNCNSFGSKSFDCEASGQCWCQPGVAGKKCDRCAHGYFNFQEGGCIACDCSHLGNNCDPKTGQCICPPNTTGEKCSECLPNTWGHSIVTGCKVCNCSTVGSLASQCNVNTGQCSCHPKFSGMKCSECSRGHWNYPLCTLCDCFLPGTDATTCDLETRKCSCSDQTGQCSCKVNVEGVHCDRCRPGKFGLDAKNPLGCSSCYCFGVTSQCSEAKGLIRTWVTLSDEQTILPLVDEALQHTTTKGIAFQKPEIVAKMDEVRQELHLEPFYWKLPQQFEGKKLMAYGGKLKYAIYFEARDETGFATYKPQVIIRGGTPTHARIITRHMAAPLIGQLTRHEIEMTEKEWKYYGDDPRISRTVTREDFLDILYDIHYILIKATYGNVVRQSRISEISMEVAEPGHVLAGSPPAHLIERCDCPPGYSGLSCETCAPGFYRLRSEPGGRTPGPTLGTCVPCQCNGHSSQCDPETSVCQNCQHHTAGDFCERCALGYYGIVRGLPNDCQPCACPLISPSNNFSPSCVLEGLEDYRCTACPRGYEGQYCERCAPGYTGSPSSPGGSCQECECDPYGSLPVPCDRVTGLCTCRPGATGRKCDGCEHWHAREGAECVFCGDECTGLLLGDLARLEQMTMNINLTGPLPAPYKILYGLENTTQELKHLLSPQRAPERLIQLAEGNVNTLVMETNELLTRATKVTADGEQTGQDAERTNSRAESLEEFIKGLVQDAEAINEKAVQLNETLGNQDKTAERNLEELQKEIDRMLKELRSKDLQTQKEVAEDELVAAEGLLKRVNKLFGEPRAQNEDMEKDLQQKLAEYKNKLDDAWDLLREATDKTRDANRLSAANQKNMTILETKKEAIEGSKRQIENTLKEGNDILDEANRLLGEINSVIDYVDDIKTKLPPMSEELSDKIDDLAQEIKDRRLAEKVFQAESHAAQLNDSSAVLDGILDEAKNISFNATAAFRAYSNIKDYIDEAEKVAREAKELAQGATKLATSPQGLLKEDAKGSLQKSFRILNEAKKLANDVKGNHNDLNDLKTRLETADLRNSGLLGALNDTMDKLSAITNDTAAKLQAVKEKAREANDTAKAVLAQVKDLHQNLDGLKQNYNKLADSVAKTNAVVKDPSKNKIIADAGTSVRNLEQEADRLIDKLKPIKELEDNLKKNISEIKELINQARKQANSIKVSVSSGGDCVRTYRPEIKKGSYNNIVVHVKTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRIEASRTGRNGSISVRALDGPKASMVPSTYHSVSPPGYTILDVDANAMLFVGGLTGKIKKADAVRVITFTGCMGETYFDNKPIGLWNFREKEGDCKGCTVSPQVEDSEGTIQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLKDFMSVELSDGHVKVSYDLGSGMTSVVSNQNHNDGKWKAFTLSRIQKQANISIVDIDSNQEENVATSSSGNNFGLDLKADDKIYFGGLPTLRNLSMKARPEVNVKKYSGCLKDIEISRTPYNILSSPDYVGVTKGCSLENVYTVSFPKPGFVELAAVSIDVGTEINLSFSTRNESGIILLGSGGTLTPPRRKRRQTTQAYYAIFLNKGRLEVHLSSGTRTMRKIVIKPEPNLFHDGREHSVHVERTRGIFTVQIDEDRRHMQNLTEEQPIEVKKLFVGGAPPEFQPSPLRNIPAFQGCVWNLVINSIPMDFAQPIAFKNADIGRCTYQKPREDESEAVPAEVIVQPQPVPTPAFPFPAPTMVHGPCVAESEPALLTGSKQFGLSRNSHIAIAFDDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRNGFPYFSYDLGSGDTSTMIPTKINDGQWHKIKIVRVKQEGILYVDDASSQTISPKKADILDVVGILYVGGLPINYTTRRIGPVTYSLDGCVRNLHMEQAPVDLDQPTSSFHVGTCFANAESGTYFDGTGFAKAVGGFKVGLDLLVEFEFRTTRPTGVLLGVSSQKMDGMGIEMIDEKLMFHVDNGAGRFTAIYDAGIPGHMCNGQWHKVTAKKIKNRLELVVDGNQVDAQSPNSASTSADTNDPVFVGGFPGGLNQFGLTTNIRFRGCIRSLKLTKGTGKPLEVNFAKALELRGVQPVSCPTT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	N-linked_Glycosylation	SNALITTNATCGEKG HCCEEECCCCCCCCC	25.30	-
85	N-linked_Glycosylation	QCRICNQNSSNPYQR CCCCCCCCCCCCCCC	33.15	-
246	Phosphorylation	LRFQRIRTLNADLMM HHHHHHHHCCCCEEH	23.22	-
299	N-linked_Glycosylation	CPLDPATNKSRCECE CCCCCCCCHHHCCCC	42.27	-
359	N-linked_Glycosylation	DETVASRNLSLNIHG CCCHHCCCEEEEEEC	31.33	-
376	N-linked_Glycosylation	IGGGVCINCTHNTAG ECCCEEEECCCCCCC	21.36	-
395	Dimethylation	TCVDGFFRPKGVSPN CEECCCCCCCCCCCC	29.74	-
395	Methylation	TCVDGFFRPKGVSPN CEECCCCCCCCCCCC	29.74	54540705
466	N-linked_Glycosylation	YPDCQPCNCSGLGST CCCCCCCCCCCCCCC	29.67	-
742	N-linked_Glycosylation	WPRHRRVNGTIFGGI CCCCCCCCCEEECCC	39.83	-
919	N-linked_Glycosylation	QPCRCNINGSFSEIC CCCCCCCCCCHHHHE	27.14	-
1031	N-linked_Glycosylation	GQCICPPNTTGEKCS CCCCCCCCCCCCCHH	35.10	-
1057	N-linked_Glycosylation	VTGCKVCNCSTVGSL CCCCCCCCCCCHHHH	26.26	-
1232	Acetylation	HLEPFYWKLPQQFEG CCCHHCCCCCHHHCC	38.62	6567405
1245	Phosphorylation	EGKKLMAYGGKLKYA CCEEEEEECCEEEEE	16.67	27180971
1593	N-linked_Glycosylation	EQMTMNINLTGPLPA HHCCCCCCCCCCCCC	26.92	-
1610	N-linked_Glycosylation	KILYGLENTTQELKH EEEEECCCHHHHHHH	54.17	-
1651	Phosphorylation	NELLTRATKVTADGE HHHHHHHEEECCCCH	23.82	30635358
1654	Phosphorylation	LTRATKVTADGEQTG HHHHEEECCCCHHCC	22.16	30635358
1669	Phosphorylation	QDAERTNSRAESLEE CCHHHHHHHHHHHHH	32.05	21183079
1673	Phosphorylation	RTNSRAESLEEFIKG HHHHHHHHHHHHHHH	39.84	19060867
1696	N-linked_Glycosylation	NEKAVQLNETLGNQD HHHHHHHHHHHCCCH	34.19	-
1806	N-linked_Glycosylation	LSAANQKNMTILETK HHHHHHHCCCHHHHH	24.06	-
1897	N-linked_Glycosylation	ESHAAQLNDSSAVLD HHHHHHCCCCHHHHH	34.73	-
1912	N-linked_Glycosylation	GILDEAKNISFNATA HHHHHHHHCCCCHHH	42.03	-
1916	N-linked_Glycosylation	EAKNISFNATAAFRA HHHHCCCCHHHHHHH	29.59	-
2013	N-linked_Glycosylation	SGLLGALNDTMDKLS HHHHHHHHHHHHHHH	42.02	-
2024	N-linked_Glycosylation	DKLSAITNDTAAKLQ HHHHHHCCHHHHHHH	38.22	-
2041	N-linked_Glycosylation	KEKAREANDTAKAVL HHHHHHCHHHHHHHH	42.27	-
2084	Acetylation	AVVKDPSKNKIIADA CEECCCCCCEEEECC	68.59	22902405
2084	Acetylation	AVVKDPSKNKIIADA CEECCCCCCEEEECC	68.59	-
2122	N-linked_Glycosylation	LEDNLKKNISEIKEL HHHHHHHCHHHHHHH	41.24	-
2236	N-linked_Glycosylation	EASRTGRNGSISVRA EECCCCCCCCEEEEE	50.32	-
2356	N-linked_Glycosylation	RPIRWYPNISTVMFK CCEEECCCCCEEEEE	25.75	-
2366	Phosphorylation	TVMFKFRTFSSSALL EEEEEEECCCHHHHH	30.88	21183079
2368	Phosphorylation	MFKFRTFSSSALLMY EEEEECCCHHHHHHH	23.83	30635358
2369	Phosphorylation	FKFRTFSSSALLMYL EEEECCCHHHHHHHH	18.55	30635358
2370	Phosphorylation	KFRTFSSSALLMYLA EEECCCHHHHHHHHH	23.03	30635358
2375	Phosphorylation	SSSALLMYLATRDLK CHHHHHHHHHHCCHH	7.99	21183079
2378	Phosphorylation	ALLMYLATRDLKDFM HHHHHHHHCCHHHHC	23.32	30635358
2431	N-linked_Glycosylation	SRIQKQANISIVDID HHHHHHCCEEEEECC	26.50	-
2474	N-linked_Glycosylation	GGLPTLRNLSMKARP CCHHHHCCCCCCCCC	39.31	-
2547	N-linked_Glycosylation	IDVGTEINLSFSTRN EECCCEEEEEEECCC	24.33	-
2554	N-linked_Glycosylation	NLSFSTRNESGIILL EEEEECCCCCCEEEE	48.12	-
2556	Phosphorylation	SFSTRNESGIILLGS EEECCCCCCEEEECC	38.55	26026062
2563	Phosphorylation	SGIILLGSGGTLTPP CCEEEECCCCCCCCC	33.74	26026062
2566	Phosphorylation	ILLGSGGTLTPPRRK EEECCCCCCCCCCHH	30.86	26026062
2568	Phosphorylation	LGSGGTLTPPRRKRR ECCCCCCCCCCHHCC	30.96	27149854
2608	Acetylation	TMRKIVIKPEPNLFH EEEEEEECCCCCCCC	32.22	22902405
2608	Acetylation	TMRKIVIKPEPNLFH EEEEEEECCCCCCCC	32.22	-
2644	N-linked_Glycosylation	EDRRHMQNLTEEQPI CCHHHHHCCCCCCCC	48.61	-
2845	Acetylation	INDGQWHKIKIVRVK CCCCCCEEEEEEEEE	42.61	-
2845	Acetylation	INDGQWHKIKIVRVK CCCCCCEEEEEEEEE	42.61	22902405
2863	Phosphorylation	ILYVDDASSQTISPK EEEEECCCCCCCCCC	29.94	21454597
2864	Phosphorylation	LYVDDASSQTISPKK EEEECCCCCCCCCCC	32.82	21454597
2868	Phosphorylation	DASSQTISPKKADIL CCCCCCCCCCCCCCC	33.77	21454597
2889	N-linked_Glycosylation	YVGGLPINYTTRRIG EECCCCCCCCCCCCC	26.59	-
2947	Acetylation	FDGTGFAKAVGGFKV ECCCCCHHCCCCEEE	37.32	-
2947	Acetylation	FDGTGFAKAVGGFKV ECCCCCHHCCCCEEE	37.32	22902405
3023	Acetylation	MCNGQWHKVTAKKIK CCCCCEEEEEHHHHC	30.10	-
3023	Acetylation	MCNGQWHKVTAKKIK CCCCCEEEEEHHHHC	30.10	22902405
3095	Acetylation	KLTKGTGKPLEVNFA EECCCCCCCEEEEEH	43.83	-
3095	Acetylation	KLTKGTGKPLEVNFA EECCCCCCCEEEEEH	43.83	22902405
3103	Acetylation	PLEVNFAKALELRGV CEEEEEHHHHHHCCC	45.48	-
3103	Acetylation	PLEVNFAKALELRGV CEEEEEHHHHHHCCC	45.48	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LAMA2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LAMA2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LAMA2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of LAMA2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.