L2GL2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: L2GL2_MOUSE
• UniProt AC: Q3TJ91
• Protein Name: Lethal(2) giant larvae protein homolog 2
• Gene Name: Llgl2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1027
• Subcellular Localization: Cytoplasm. Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells (By similarity)..
• Protein Description: Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity (By similarity)..
• Protein Sequence: MRRFLRTGHDPARERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAVKLYGAPGVEFMGLHKENNAVLQIHFLPGQCQLVTLLDDNSLHLWSLKVKGGVSELQEEESFTLRGPPGAAPSATQVTEILPHSSGELLYLGTESGNVFVVQLPGFRTLHDRTICSDEVLQWLPEEARHRRVFEMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRALSHFLSSQQLENASWQRDGCLIVTCHSDGSHCQWPVSSDTQNPEPLRSSIPYGPFPCKAITKIFWLTTRQGLPFTIFQGGMPRASYGDRHCISVVHNGQQTAFDFTSRVIDFTVLSEADPAAAFDDPYALVVLAEEELVVIDLQTPGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNSHFSTMEWPIDGGTSLAPPPPQRDLLLTGHEDGTVRFWDASGVCLRLLYKLSTVRVFLTDTDPSENLIAQGEDEWPPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLAVAGTAGQVLVLELNDEAAEHAVEQVEADLLQDQEGYRWKGHERLAARPGPVCFEAGFQPFVLVQCQPPAVVTSLALHSEWRLVAFGTSHGFGLFDHQQRRQVFVKCTLHPSDQLALEGPLSRVKSLKKSLRQSFRRMRRSRVSSHKRRPGGPTGEAQAQAVNIKAERTGLQNMELAPVQRKIEARSAEDSFTGFVRTLYFADTYLRDSSRHCPSLWAGTNGGTVYAFSLRVPPAERRTDEPVRAEQAKEIQLMHRAPVVGILVLDGHNVPLPEPLEVAHDLSKSPDMQGSHQLLVVSEEQFKVFTLPKVSAKLKLKLTALEGSRVRRVGVAHFGSCRAEDYGEHHLAVLTNLGDIQVVSMPLLKPQVRYSCIRREDVSGIASCVFTKYGQGFYLISPSEFERFSLSTKWLVEPRCLVDSTKAKKHNRPSNGNGTGLKMTSSGHVRNSKSQSDGDEKKPGPVMEHALLNDAWVLKEIQSTLEGDRRSYGNWHPHRVAVGCRLSNGEAE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
208	Phosphorylation	PNQILIGYSRGLVVI HHCEEEEECCCEEEE	6.54	30482847
209	Phosphorylation	NQILIGYSRGLVVIW HCEEEEECCCEEEEE	18.05	30482847
476	Phosphorylation	FLTDTDPSENLIAQG EECCCCCCCCCCCCC	41.76	26239621
499	Phosphorylation	KVGSFDPYSDDPRLG CCCCCCCCCCCCCCC	26.95	-
641	Phosphorylation	LALEGPLSRVKSLKK HHHCCCHHHHHHHHH	37.85	-
645	Phosphorylation	GPLSRVKSLKKSLRQ CCHHHHHHHHHHHHH	42.43	28382018
649	Phosphorylation	RVKSLKKSLRQSFRR HHHHHHHHHHHHHHH	27.48	25521595
653	Phosphorylation	LKKSLRQSFRRMRRS HHHHHHHHHHHHHHH	17.81	25521595
664	Phosphorylation	MRRSRVSSHKRRPGG HHHHHHHHCCCCCCC	30.12	28059163
684	Ubiquitination	QAQAVNIKAERTGLQ HHHHHHHEEHHHCCC	38.70	22790023
825	Phosphorylation	EEQFKVFTLPKVSAK HHHEEEEECCCCCCC	45.17	22817900
828	Ubiquitination	FKVFTLPKVSAKLKL EEEEECCCCCCCCEE	52.51	22790023
855	Phosphorylation	VGVAHFGSCRAEDYG EEEEEECCCCHHHCC	10.25	28973931
939	Phosphorylation	EPRCLVDSTKAKKHN CCCEEECCCCCCCCC	25.07	24759943
940	Phosphorylation	PRCLVDSTKAKKHNR CCEEECCCCCCCCCC	30.47	24759943
949	Phosphorylation	AKKHNRPSNGNGTGL CCCCCCCCCCCCCCC	54.88	29899451
960	Phosphorylation	GTGLKMTSSGHVRNS CCCCEECCCCCCCCC	30.72	21454597
961	Phosphorylation	TGLKMTSSGHVRNSK CCCEECCCCCCCCCC	24.61	20469934
967	Phosphorylation	SSGHVRNSKSQSDGD CCCCCCCCCCCCCCC	24.10	25338131
969	Phosphorylation	GHVRNSKSQSDGDEK CCCCCCCCCCCCCCC	34.44	-
971	Phosphorylation	VRNSKSQSDGDEKKP CCCCCCCCCCCCCCC	51.13	-
1006	Phosphorylation	TLEGDRRSYGNWHPH HHCCCHHHCCCCCCC	37.98	26239621
1007	Phosphorylation	LEGDRRSYGNWHPHR HCCCHHHCCCCCCCE	16.80	26239621
1022	Phosphorylation	VAVGCRLSNGEAE-- EEEEEEECCCCCC--	24.36	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of L2GL2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
653	S	Phosphorylation	Phosphorylated at Ser-653 by PRKCI.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of L2GL2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of L2GL2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.