dbPTM

L2GL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	L2GL1_MOUSE
UniProt AC	Q80Y17
Protein Name	Lethal(2) giant larvae protein homolog 1
Gene Name	Llgl1
Organism	Mus musculus (Mouse).
Sequence Length	1036
Subcellular Localization	Early endosome membrane. Golgi apparatus, trans-Golgi network membrane. Golgi apparatus membrane. Cell projection, axon. Cytoplasm, cytoskeleton. Localized to the lateral membrane during the polarization and formation cell-cell contacts. Enriched in
Protein Description	Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane..
Protein Sequence	MMKFRFRRQGADPQREKLKQELFAFHKTVEHGFPNQPSALAFDPELRIMAIGTRSGAVKIYGAPGVEFTGLHRDAATVTQMHFLPGQGRLLTLLDDSSLHLWEIIHHNGCAHLEEGLSFHPPSRPSFDNASFPASLTRVTVVLLVAGNTAALGTESGSIFFLDVATLALLEGQTLSPDVVLRSVPDDYRCGKALGPVESLQGHLQDPSKILIGYSRGLLVIWSQATQSVDNVFLGNQQLESLCWGRDGSSIISSHSDGSYAIWSTDTGSPPTLQPTVVTTPYGPFPCKAINKILWRSCESGDHFIIFSGGMPRASYGDRHCVSVLRAETLVTLDFTSRVIDFFTVHSTQPEDECDNPQALAVLLEEELVVLDLQTPGWPAVPAPYLAPLHSSAITCSAHVANVPSKLWARIVSAGEQQSPQPASSALSWPITGGRNLAQEPSQRGLLLTGHEDGTVRFWDASGVALRPLYKLSTAGLFQTDCEHADSLAQAVEDDWPPFRKVGCFDPYSDDPRLGIQKVALCKYTAQMVVAGTAGQVLVLELSEVPAEHAVSVANVDLLQDREGFTWKGHERLNPHTGLLPWPAGFQPRMLIQCLPPAAVTAVTLHAEWSLVAFGTSHGFGLFDYQRKSPVLARCTLHPNDSLAMEGPLSRVKSLKKSLRQSFRRIRKSRVSGKKRTPAASSKLQEANAQLAEQTCPHDLEMTPVQRRIEPRSADDSLSGVVRCLYFADTFLRDATHHGPTMWAGTNSGSVFAYALEVPAATAGGEKRPEQAVEAVLGKEVQLMHRAPVVAIAVLDGRGRPLPEPYEASRDLAQAPDMQGGHAVLIASEEQFKVFTLPKVSAKTKFKLTAHEGCRVRKVALATFASVMSEDYAETCLACLTNLGDVHVFSVPGLRPQVHYSCIRKEDISGIASCVFTRHGQGFYLISPSEFERFSLSARNITEPLCSLDISWPQNATQPRLQESPKLSQANGTRDIILAPESCEGSPSSAHSKRADTMEPPEAALSPVSIDSAASGDTMLDTTGDVTVEYVKDFLG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
419	Phosphorylation	VSAGEQQSPQPASSA HCCCCCCCCCCCHHH	25.79	29514104
487	Phosphorylation	TDCEHADSLAQAVED CCCCCHHHHHHHHHC	26.79	29899451
508	Phosphorylation	KVGCFDPYSDDPRLG CCCCCCCCCCCCCCC	26.95	-
650	Phosphorylation	LAMEGPLSRVKSLKK CHHCCCHHHHHHHHH	37.85	-
654	Phosphorylation	GPLSRVKSLKKSLRQ CCHHHHHHHHHHHHH	42.43	24719451
658	Phosphorylation	RVKSLKKSLRQSFRR HHHHHHHHHHHHHHH	27.48	25521595
662	Phosphorylation	LKKSLRQSFRRIRKS HHHHHHHHHHHHHHH	17.81	25521595
672	Phosphorylation	RIRKSRVSGKKRTPA HHHHHHCCCCCCCCH	43.73	-
703	Phosphorylation	CPHDLEMTPVQRRIE CCCCCCCCCCCCCCC	15.78	29514104
836	Phosphorylation	EEQFKVFTLPKVSAK HHHEEEEEECCCCCC	45.17	24719451
839	Ubiquitination	FKVFTLPKVSAKTKF EEEEEECCCCCCCCE	52.51	-
905	Ubiquitination	VHYSCIRKEDISGIA EEEEEEEHHHCCEEE	39.57	22790023
935	Phosphorylation	PSEFERFSLSARNIT HHHHHHEECCCCCCC	27.86	30387612
957	Phosphorylation	ISWPQNATQPRLQES CCCCCCCCCCCCCCC	46.81	17525332
964	Phosphorylation	TQPRLQESPKLSQAN CCCCCCCCCCHHHCC	17.86	27087446
968	Phosphorylation	LQESPKLSQANGTRD CCCCCCHHHCCCCCC	33.11	25619855
973	Phosphorylation	KLSQANGTRDIILAP CHHHCCCCCCEEECC	25.60	25619855
982	Phosphorylation	DIILAPESCEGSPSS CEEECCCCCCCCCCC	19.19	24925903
986	Phosphorylation	APESCEGSPSSAHSK CCCCCCCCCCCCCCC	10.18	24925903
988	Phosphorylation	ESCEGSPSSAHSKRA CCCCCCCCCCCCCCC	41.68	24925903
989	Phosphorylation	SCEGSPSSAHSKRAD CCCCCCCCCCCCCCC	33.13	24925903
992	Phosphorylation	GSPSSAHSKRADTME CCCCCCCCCCCCCCC	24.45	24925903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of L2GL1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
658	S	Phosphorylation	12629547
Phosphorylated by PRKCI on at least one of the following Ser residues: Ser 654, Ser-658, Ser-662, Ser-669 and Ser-672.
662	S	Phosphorylation	12629547
Phosphorylated by PRKCI on at least one of the following Ser residues: Ser 654, Ser-658, Ser-662, Ser-669 and Ser-672.
669	S	Phosphorylation	12629547
Phosphorylated by PRKCI on at least one of the following Ser residues: Ser 654, Ser-658, Ser-662, Ser-669 and Ser-672.
672	S	Phosphorylation	12629547
Phosphorylated by PRKCI on at least one of the following Ser residues: Ser 654, Ser-658, Ser-662, Ser-669 and Ser-672.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of L2GL1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of L2GL1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of L2GL1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-964, AND MASSSPECTROMETRY.	19144319 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-957, AND MASSSPECTROMETRY.	17525332 [Abstract]

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