KTNB1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KTNB1_MOUSE
• UniProt AC: Q8BG40
• Protein Name: Katanin p80 WD40 repeat-containing subunit B1 {ECO:0000255|HAMAP-Rule:MF_03022}
• Gene Name: Katnb1
• Organism: Mus musculus (Mouse).
• Sequence Length: 658
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, spindle . Predominantly cytoplasmic. Localized to the interphase centrosome an
• Protein Description: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. The function in regulating microtubule dynamics at spindle poles seems to depend on the association of the katanin KATNA1:KATNB1 complex with ASPM which recruits it to microtubules. Reversely KATNA1:KATNB1 can enhance ASPM blocking activity on microtubule minus-end growth. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth..
• Protein Sequence: MATPVVTKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVVLVNWGKVADLAICNDQLIGVAFSQSNVSSYVVDLTRVTRTGTVTQDPVQANQPLTQQTPNPGVSLRRIYERPSTTCSKPQRVKHNSESERRSPSSEDDRDERESRAEIQNAEDYNEIFQPKNSISRTPPRRSEPFPAPPEDDAATVKEVSKPSPAMDVQLPQLPVPNLEVPARPSVMTSTPAPKGEPDIIPATRNEPIGLKASDFLPAVKVPQQAELVDEDAMSQIRKGHDTMFVVLTSRHKNLDTVRAVWTTGDIKTSVDSAVAINDLSVVVDLLNIVNQKASLWKLDLCTTVLPQIEKLLQSKYESYVQTGCTSLKLILQRFLPLITDILAAPPSVGVDISREERLHKCRLCFKQLKSISGLVKSKSGLSGRHGSAFRELHLLMASLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MATPVVTKTA -----CCCCCCCHHH	18.47	26026062
38	Phosphorylation	ASGRLLATGGDDCRV CCCCEEEECCCCCEE	41.49	28059163
96	Ubiquitination	VWDLEAAKILRTLMG EEEHHHHHHHHHHHC	49.69	22790023
337	Phosphorylation	GVSLRRIYERPSTTC CCCCEEEEECCCCCC	12.22	22817900
354	Phosphorylation	PQRVKHNSESERRSP CCCCCCCCCCCCCCC	42.07	25266776
356	Phosphorylation	RVKHNSESERRSPSS CCCCCCCCCCCCCCC	35.90	25266776
360	Phosphorylation	NSESERRSPSSEDDR CCCCCCCCCCCCCCH	35.04	25521595
362	Phosphorylation	ESERRSPSSEDDRDE CCCCCCCCCCCCHHH	47.83	23684622
363	Phosphorylation	SERRSPSSEDDRDER CCCCCCCCCCCHHHH	48.72	25521595
391	Phosphorylation	EIFQPKNSISRTPPR HHHCCCCCCCCCCCC	28.24	29899451
393	Phosphorylation	FQPKNSISRTPPRRS HCCCCCCCCCCCCCC	29.89	25159016
395	Phosphorylation	PKNSISRTPPRRSEP CCCCCCCCCCCCCCC	30.74	25159016
400	Phosphorylation	SRTPPRRSEPFPAPP CCCCCCCCCCCCCCC	51.40	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KTNB1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KTNB1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KTNB1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of KTNB1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.