KS6A1_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KS6A1_CAEEL
• UniProt AC: Q21734
• Protein Name: Putative ribosomal protein S6 kinase alpha-1
• Gene Name: rskn-1
• Organism: Caenorhabditis elegans.
• Sequence Length: 784
• Protein Description: Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of transcription (By similarity). Suppresses germline tumor formation by preventing the dedifferentiation of secondary spermatocytes probably downstream of mpk-1. [PubMed: 22820175]
• Protein Sequence: MGLQRGMPLAQLGEPFGITPSSIENVSPGIDQCKDHRMDVSMRSDPTDCSSDTTNTFHSSIHIIQPPPNNGFRLMNWKTDSSSETEIDIGDVRKCGEKADPRQFELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATLKVRDRQRTKLERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAIDSEKKTYSFCGTVEYMAPEVINRRGHSMAADFWSLGVLMFEMLTGHLPFQGRDRNDTMTQILKAKLSMPHFLTQEAQSLLRALFKRNSQNRLGAGPDGVEEIKRHAFFAKIDFVKLLNKEIDPPFKPALSTVDSTSYFDPEFTKRTPKDSPALPASANGHEIFRGFSFVSNAVMEERKLIAKSVRSVPTAKTNPFTDDYEILEKIGNGAHSVVHKCQMKATRRKYAVKIVKKAVFDATEEVDILLRHSHHQFVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLGSEKEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAKQSRAENGMLMTPCYTAQFVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPFAMGPNDTPDQILQRVGDGKISMTHPVWDTISDEAKDLVRKMLDVDPNRRVTAKQALQHKWIGQKEALPDRPIQSEQVGELDMQNVKVALEQTYKAIASAPSVQLRPVGSSALAKRRMKEILYANYTKNVSANA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	PSSIENVSPGIDQCK HHHHCCCCCCCHHHH	29.05	28854356
263	Phosphorylation	DSEKKTYSFCGTVEY CCCCCCEEECCCHHH	21.20	-
401	Phosphorylation	DPEFTKRTPKDSPAL CHHHHCCCCCCCCCC	35.92	19530675
405	Phosphorylation	TKRTPKDSPALPASA HCCCCCCCCCCCCCC	20.42	28854356
411	Phosphorylation	DSPALPASANGHEIF CCCCCCCCCCCCCHH	21.96	18806794
422	Phosphorylation	HEIFRGFSFVSNAVM CCHHHCCCHHHCHHH	27.80	-
610	Phosphorylation	AENGMLMTPCYTAQF CCCCCCCCCCHHHHH	13.27	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KS6A1_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KS6A1_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KS6A1_CAEEL !!

Protein-Protein Interaction

Oops, there are no PPI records of KS6A1_CAEEL !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.