KLHL4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLHL4_HUMAN
• UniProt AC: Q9C0H6
• Protein Name: Kelch-like protein 4
• Gene Name: KLHL4
• Organism: Homo sapiens (Human).
• Sequence Length: 718
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Sequence: MSVSGKKEFDVKQILRLRWRWFSHPFQGSTNTGSCLQQEGYEHRGTPVQGRLKSHSRDRNGLKKSNSPVHHNILAPVPGPAPAHQRAVQNLQQHNLIVHFQANEDTPKSVPEKNLFKEACEKRAQDLEMMADDNIEDSTARLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVVKLP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Phosphorylation	EGYEHRGTPVQGRLK CCCCCCCCCCCCCCC	21.90	28060719
56	Phosphorylation	QGRLKSHSRDRNGLK CCCCCCCCCCCCCCC	42.86	28674151
171	Ubiquitination	HAEQTLRKMENYLKE HHHHHHHHHHHHHHH	54.39	-
175	Phosphorylation	TLRKMENYLKEKQLC HHHHHHHHHHHHHHH	13.07	22210691
177	Ubiquitination	RKMENYLKEKQLCDV HHHHHHHHHHHHHHH	53.13	-
369	Phosphorylation	GELGMLLSYIRLPLL CHHHHHHHHHCCCCC	17.98	-
414	Phosphorylation	HLLPERRSMMQSPRT CCCHHHHHHHCCCCC	25.48	30177828
418	Phosphorylation	ERRSMMQSPRTKPRK HHHHHHCCCCCCCCC	9.84	30177828
421	Phosphorylation	SMMQSPRTKPRKSTV HHHCCCCCCCCCCHH	49.11	30177828
426	Phosphorylation	PRTKPRKSTVGALYA CCCCCCCCHHHHHHH	29.60	22210691
427	Phosphorylation	RTKPRKSTVGALYAV CCCCCCCHHHHHHHC	26.45	22210691
432	Phosphorylation	KSTVGALYAVGGMDA CCHHHHHHHCCCCCC	9.94	22210691
441	Ubiquitination	VGGMDAMKGTTTIEK CCCCCCCCCCCEEEE	55.62	-
448	Ubiquitination	KGTTTIEKYDLRTNS CCCCEEEEEECCCCC	39.97	-
488	Ubiquitination	VGGRDGLKTLNTVEC ECCCCCCCCCCCEEE	57.40	-
552	Phosphorylation	PEGRQWNYVASMSTP CCCCCEEEEEECCCC	8.40	18669648
557	Phosphorylation	WNYVASMSTPRSTVG EEEEEECCCCCCEEE	32.53	18669648
585	Ubiquitination	RDGSSCLKSMEYFDP CCCCHHHHHHCCCCC	52.67	-
589	Phosphorylation	SCLKSMEYFDPHTNK HHHHHHCCCCCCCCC	12.49	24719451
594	Phosphorylation	MEYFDPHTNKWSLCA HCCCCCCCCCEEEEE	43.83	24719451
596	Ubiquitination	YFDPHTNKWSLCAPM CCCCCCCCEEEEEEC	39.04	-
646	Ubiquitination	CVERYDPKGDSWSTV HHHHCCCCCCCCCCE	72.89	-
657	Phosphorylation	WSTVAPLSVPRDAVA CCCEECCCCCCCEEE	29.08	24719451
698	Ubiquitination	DAQRNEWKEEVPVNI CHHCCCCCCCCCCCC	37.51	-
700 (in isoform 2)	Phosphorylation	-	48.68	22798277
710 (in isoform 2)	Phosphorylation	-	5.07	22798277

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLHL4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLHL4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLHL4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of KLHL4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.