KLHL2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLHL2_MOUSE
• UniProt AC: Q8JZP3
• Protein Name: Kelch-like protein 2
• Gene Name: Klhl2 {ECO:0000312|MGI:MGI:1924363}
• Organism: Mus musculus (Mouse).
• Sequence Length: 593
• Subcellular Localization: Cytoplasm, cytoskeleton . Cell projection, ruffle . Cell projection. Cell projection, lamellipodium. Cytoplasm, cytosol . A proportion colocalizes with the actin cytoskeleton (By similarity). When over-expressed, colocalizes with NPTXR in perinuclear
• Protein Description: Promotes growth of cell projections in oligodendrocyte precursors. Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4 (By similarity). Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. Plays a role in the reorganization of the actin cytoskeleton..
• Protein Sequence: METPPLPPACTKQGHQKPLDSKDENPEKHCPLTVNPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEIPAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLVDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRMLMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATANEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----METPPLPPAC -----CCCCCCCCCC	28.98	26643407
350	Phosphorylation	RCRAGMVYMAGLVFA CHHHHHHHHHHEEEE	3.41	25777480
364	Phosphorylation	AVGGFNGSLRVRTVD EECCCCCEEEEEEEC	17.69	25777480

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLHL2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLHL2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLHL2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL3_MOUSE	Cul3	physical	21549840
CUL3_HUMAN	CUL3	physical	21549840

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.