KLHL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLHL1_MOUSE
• UniProt AC: Q9JI74
• Protein Name: Kelch-like protein 1
• Gene Name: Klhl1
• Organism: Mus musculus (Mouse).
• Sequence Length: 751
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: May play a role in organizing the actin cytoskeleton of the brain cells..
• Protein Sequence: MSGSGRKDFDVKHILRLRWKLFSHPSPASSSPAGGSCLQQDSGGGSFEHWGPSQSRLLKNQEKGSVSAFWKKPSSSSSSSSSSSSSASSSPFNPLNGTLLPVATRLQQGAPGQGTQQPARTLFYVESLEEEVVTGMDFSGPEDKGLALKELQAEPASSIQATGEGCGHRLTSTNHSLTPQSDLDSSSSEEFYQAVHHAEQSFRKMENYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRCSDLSMLLAFIRLPLLPPQILADLENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTYVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWSMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIKQP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
80	Phosphorylation	PSSSSSSSSSSSSSA CCCCCCCCCCCCCCC	35.87	-
82	Phosphorylation	SSSSSSSSSSSSASS CCCCCCCCCCCCCCC	35.87	-
84	Phosphorylation	SSSSSSSSSSASSSP CCCCCCCCCCCCCCC	30.20	-
98	Phosphorylation	PFNPLNGTLLPVATR CCCCCCCCCCCHHHH	24.85	-
104	Phosphorylation	GTLLPVATRLQQGAP CCCCCHHHHHHCCCC	31.95	-
338	Phosphorylation	ELMKVAHSYTMENIM HHHHHHHHCCHHHHH	16.74	-
339	Phosphorylation	LMKVAHSYTMENIME HHHHHHHCCHHHHHH	10.55	-
537	Phosphorylation	NPKTKTWTVLPPMST CCCCCEEEECCCCCC	19.86	30635358
543	Phosphorylation	WTVLPPMSTHRHGLG EEECCCCCCCCCCCE	27.17	30635358
544	Phosphorylation	TVLPPMSTHRHGLGV EECCCCCCCCCCCEE	19.37	30635358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLHL1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLHL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLHL1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of KLHL1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.