dbPTM

KLF10_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KLF10_MOUSE
UniProt AC	O89091
Protein Name	Krueppel-like factor 10
Gene Name	Klf10
Organism	Mus musculus (Mouse).
Sequence Length	479
Subcellular Localization	Nucleus .
Protein Description	Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. May play a role in the cell cycle regulation (By similarity). Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis..
Protein Sequence	MLNFGASLQQASEGKMELISEKPREGMHPWDKAEQSDFEAVEALMSMSCDWKSHFKKYLENRPVTPVSDTSEDDSLLPGTPDLQTVPAFCLTPPYSPSDFEPSQGSNLTASAPSTGHFKSFSDAAKPPGATPFKEEEKNPLAAPPLPKAQATSVIRHTADAQLCNHQSCPVKAASILNYQDNSFRRRTHGNVEATRKNIPCAAVSPNRSKPEPSTVSDGDEKAGAALYDFAVPSSETVICRSQPAPSSPVQKSVLVSSPTVSTGGVPPLPVICQMVPLPANNSLVSTVVPSTPPSQPPAVCSPVLFMGTQVPEGTVVFVVPQPVVQSPRPPVVSPSGTRLSPIAPAPGFSPSAARVTPQIDSSRVRSHICSHPGCGKTYFKSSHLKAHVRTHTGEKPFSCSWKGCERRFARSDELSRHRRTHTGEKKFACPMCDRRFMRSDHLTKHARRHLSAKKLPNWQMEVSKLNDIALPPTPASAQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
179	Phosphorylation	KAASILNYQDNSFRR CHHHHHCCCCCCCHH	17.50	21471442
183	Phosphorylation	ILNYQDNSFRRRTHG HHCCCCCCCHHHCCC	28.55	-
188	Phosphorylation	DNSFRRRTHGNVEAT CCCCHHHCCCCHHHH	32.12	-
205	Phosphorylation	NIPCAAVSPNRSKPE CCCCEEECCCCCCCC	16.25	25619855
217	Phosphorylation	KPEPSTVSDGDEKAG CCCCCCCCCCCHHCC	35.64	27149854
234	Phosphorylation	LYDFAVPSSETVICR EEEEECCCCCEEEEE	33.92	26643407
235	Phosphorylation	YDFAVPSSETVICRS EEEECCCCCEEEEEC	31.08	26643407
237	Phosphorylation	FAVPSSETVICRSQP EECCCCCEEEEECCC	19.67	26643407
242	Phosphorylation	SETVICRSQPAPSSP CCEEEEECCCCCCCC	35.78	26643407
247	Phosphorylation	CRSQPAPSSPVQKSV EECCCCCCCCCCEEE	49.75	26643407
248	Phosphorylation	RSQPAPSSPVQKSVL ECCCCCCCCCCEEEE	28.21	24453211
315	Phosphorylation	GTQVPEGTVVFVVPQ CEECCCCEEEEEECC	16.31	-
403	Acetylation	KPFSCSWKGCERRFA CCCCCCCCCHHHHHH	37.07	7720343

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
179	Y	Phosphorylation	Kinase	TYK2	P29597	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	Itch	Q8C863	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KLF10_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KLF10_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of KLF10_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KLF10_MOUSE

Related Literatures of Post-Translational Modification