KLDC2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLDC2_MOUSE
• UniProt AC: Q4G5Y1
• Protein Name: Kelch domain-containing protein 2
• Gene Name: Klhdc2
• Organism: Mus musculus (Mouse).
• Sequence Length: 406
• Subcellular Localization: Nucleus.
• Protein Description: Represses CREB3-mediated transcription by interfering with CREB3-DNA binding..
• Protein Sequence: MADGNEDARAEDLPGPAFENYEAMELACPAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSADRGLQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDTETFAWSQPITTGKAPSPRAAHACATVGNKGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGVCPVGRSWHSLTPVSSDHLFLFGGFTTEKQPLSDAWTYCISKNEWIQFNHPYVEKPRLWHTACASDEGEVIVFGGCANNLLVHHRAAHSNEVLIFSVQPKSLVRLSLEAVICFKEMLANSWSCLPKHLLHSVNQRFGSNNTSGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
117	Ubiquitination	HSRGNTNKFYMLDSR CCCCCCCCEEEECCC	35.51	22790023
147	Ubiquitination	IPPSSKDKLGVWVYK CCCCCCCCCEEEEEC	51.37	22790023
382	Phosphorylation	FKEMLANSWSCLPKH HHHHHHHCCCCCCHH	18.11	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLDC2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLDC2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLDC2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of KLDC2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.