dbPTM

KLD10_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KLD10_MOUSE
UniProt AC	Q6PAR0
Protein Name	Kelch domain-containing protein 10
Gene Name	Klhdc10
Organism	Mus musculus (Mouse).
Sequence Length	439
Subcellular Localization	Nucleus. Cytoplasm. Isoform 2: Cytoplasm .
Protein Description	Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5..
Protein Sequence	MSAAQGWDRNRRRGGGAAGGASGVSGAGAAGGGRGTGQLNRFVQLSGRPHLPGKKKIRWDPVRRRFIQSCPIIRIPNRFLRGHRPPPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCRGKRPSRIYGQAMALINGSLYVFGGTTGYIYSTDLHKLDLNTMVWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPATMPEPVYFHCAAVTPAGCMYIHGGVVNIHENKRTGSLFKIWLVVPSLLELAWEKLLAAFPNLANLSRTQLLHLGLTQELIERLK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Dimethylation	GWDRNRRRGGGAAGG CCCCCCCCCCCCCCC	44.89	-
13	Methylation	GWDRNRRRGGGAAGG CCCCCCCCCCCCCCC	44.89	24129315
25	Phosphorylation	AGGASGVSGAGAAGG CCCCCCCCCCCCCCC	26.84	28059163
34	Dimethylation	AGAAGGGRGTGQLNR CCCCCCCCCCCCCCC	42.65	-
34	Methylation	AGAAGGGRGTGQLNR CCCCCCCCCCCCCCC	42.65	24394791
195	Phosphorylation	YKRWALLSCRGKRPS ECEEEEHHCCCCCCC	11.56	-
401	Phosphorylation	KIWLVVPSLLELAWE HHHHHHHHHHHHHHH	33.70	21149613

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KLD10_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KLD10_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KLD10_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of KLD10_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KLD10_MOUSE

Related Literatures of Post-Translational Modification