KINH_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KINH_RAT
• UniProt AC: Q2PQA9
• Protein Name: Kinesin-1 heavy chain
• Gene Name: Kif5b {ECO:0000312|EMBL:ABC25059.1}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 963
• Subcellular Localization: Cytoplasm, cytoskeleton . Uniformly distributed between soma and neurites in hippocampal neurons.
• Protein Description: Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes..
• Protein Sequence: MADPAECNIKVMCRFRPLNESEVNRGDKYVAKFQGEDTVMIASKPYAFDRVFQSSTSQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGSTYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKTLRNTIQWLENELNRWRNGETVPIDEQFDKEKANLEAFTADKDVAITNDKPAAAIGMAGSFTDAERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQLEESVDSLGEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLRDEVEAKEKLITDLQDQNQKMVLEQERLRVEHERLKAVDQEKSRKLHELTVMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEVDSDDTGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVDRIKEAVRSKNMARRGHSAQIAKPIRPGQHPAASPTHPGAVRGGGSFVQNNQPVGLRGGGGKQA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADPAECNI ------CCCHHHCCE	31.34	-
44	Acetylation	DTVMIASKPYAFDRV CEEEEECCCCCHHHH	32.78	22902405
154	Phosphorylation	DVSKTNLSVHEDKNR CHHCCCCCCCCCCCC	24.41	30181290
357	Phosphorylation	KNKTLRNTIQWLENE HCHHHHHHHHHHHHH	14.22	18779572
412	Phosphorylation	AAIGMAGSFTDAERR HHHHCCCCCCHHHHH	18.55	28689409
414	Phosphorylation	IGMAGSFTDAERRKC HHCCCCCCHHHHHHH	35.68	25575281
448	Acetylation	QQSQLVEKLKTQMLD HHHHHHHHHHHHCCC	48.05	22902405
512	Acetylation	KSQEVEDKTKEYELL CCHHHHHHHHHHHHH	48.25	22902405
557	Phosphorylation	RAAEMMASLLKDLAE HHHHHHHHHHHHHHH	19.15	18779572
613	Phosphorylation	KRCKQLESTQTESNK HHHHHHHHHCCHHHH	34.11	25575281
614	Phosphorylation	RCKQLESTQTESNKK HHHHHHHHCCHHHHH	30.09	25575281
616	Phosphorylation	KQLESTQTESNKKME HHHHHHCCHHHHHHH	41.28	25575281
618	Phosphorylation	LESTQTESNKKMEEN HHHHCCHHHHHHHHH	58.29	25575281
717	Phosphorylation	ETHQKQISSLRDEVE HHHHHHHHHHHHHHH	22.33	18779572
755	Acetylation	RVEHERLKAVDQEKS HHHHHHHHHHCHHHH	53.22	22902405
814	Phosphorylation	LATRVKKSAEVDSDD HHHHHHHHCCCCCCC	24.76	28432305
819	Phosphorylation	KKSAEVDSDDTGGSA HHHCCCCCCCCCCCH	42.43	28432305
833	Phosphorylation	AAQKQKISFLENNLE HHHHHHHHHHHHCHH	30.71	21373199
870	Phosphorylation	LEKRLRATAERVKAL HHHHHHHHHHHHHHH	23.71	18779572
933	Phosphorylation	PGQHPAASPTHPGAV CCCCCCCCCCCCCCC	32.22	27097102
935	Phosphorylation	QHPAASPTHPGAVRG CCCCCCCCCCCCCCC	37.90	27097102
945	Phosphorylation	GAVRGGGSFVQNNQP CCCCCCCCCCCCCCC	26.06	29779826
956	Methylation	NNQPVGLRGGGGKQA CCCCCCCCCCCCCCC	35.46	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KINH_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KINH_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KINH_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of KINH_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.