KIF27_HUMAN - dbPTM
KIF27_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KIF27_HUMAN
UniProt AC Q86VH2
Protein Name Kinesin-like protein KIF27
Gene Name KIF27
Organism Homo sapiens (Human).
Sequence Length 1401
Subcellular Localization Cytoplasm, cytoskeleton . Cell projection, cilium. Localizes to centrioles and basal bodies..
Protein Description Plays an essential role in motile ciliogenesis..
Protein Sequence MEEIPVKVAVRIRPLLCKEALHNHQVCVRVIPNSQQVIIGRDRVFTFDFVFGKNSTQDEVYNTCIKPLVLSLIEGYNATVFAYGQTGSGKTYTIGGGHIASVVEGQKGIIPRAIQEIFQSISEHPSIDFNVKVSYIEVYKEDLRDLLELETSMKDLHIREDEKGNTVIVGAKECHVESAGEVMSLLEMGNAARHTGTTQMNEHSSRSHAIFTISICQVHKNMEAAEDGSWYSPRHIVSKFHFVDLAGSERVTKTGNTGERFKESIQINSGLLALGNVISALGDPRRKSSHIPYRDAKITRLLKDSLGGSAKTVMITCVSPSSSNFDESLNSLKYANRARNIRNKPTVNFSPESDRIDEMEFEIKLLREALQSQQAGVSQTTQINREGSPDTNRIHSLEEQVAQLQGECLGYQCCVEEAFTFLVDLKDTVRLNEKQQHKLQEWFNMIQEVRKAVLTSFRGIGGTASLEEGPQHVTVLQLKRELKKCQCVLAADEVVFNQKELEVKELKNQVQMMVQENKGHAVSLKEAQKVNRLQNEKIIEQQLLVDQLSEELTKLNLSVTSSAKENCGDGPDARIPERRPYTVPFDTHLGHYIYIPSRQDSRKVHTSPPMYSLDRIFAGFRTRSQMLLGHIEEQDKVLHCQFSDNSDDEESEGQEKSGTRCRSRSWIQKPDSVCSLVELSDTQDETQKSDLENEDLKIDCLQESQELNLQKLKNSERILTEAKQKMRELTINIKMKEDLIKELIKTGNDAKSVSKQYSLKVTKLEHDAEQAKVELIETQKQLQELENKDLSDVAMKVKLQKEFRKKMDAAKLRVQVLQKKQQDSKKLASLSIQNEKRANELEQSVDHMKYQKIQLQRKLREENEKRKQLDAVIKRDQQKIKEIQLKTGQEEGLKPKAEDLDACNLKRRKGSFGSIDHLQKLDEQKKWLDEEVEKVLNQRQELEELEADLKKREAIVSKKEALLQEKSHLENKKLRSSQALNTDSLKISTRLNLLEQELSEKNVQLQTSTAEEKTKISEQVEVLQKEKDQLQKRRHNVDEKLKNGRVLSPEEEHVLFQLEEGIEALEAAIEYRNESIQNRQKSLRASFHNLSRGEANVLEKLACLSPVEIRTILFRYFNKVVNLREAERKQQLYNEEMKMKVLERDNMVRELESALDHLKLQCDRRLTLQQKEHEQKMQLLLHHFKEQDGEGIMETFKTYEDKIQQLEKDLYFYKKTSRDHKKKLKELVGEAIRRQLAPSEYQEAGDGVLKPEGGGMLSEELKWASRPESMKLSGREREMDSSASSLRTQPNPQKLWEDIPELPPIHSSLAPPSGHMLGNENKTETDDNQFTKSHSRLSSQIQVVGNVGRLHGVTPVKLCRKELRQISALELSLRRSSLGVGIGSMAADSIEVSRKPRDLKT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Ubiquitination-MEEIPVKVAVRIRP
-CCCCCCEEEEECHH		21.08-
91PhosphorylationGQTGSGKTYTIGGGH
CCCCCCCEEEECCCC		29.44-
92PhosphorylationQTGSGKTYTIGGGHI
CCCCCCEEEECCCCE		10.39-
93PhosphorylationTGSGKTYTIGGGHIA
CCCCCEEEECCCCEE		20.55-
154UbiquitinationLELETSMKDLHIRED
HHHHHHHCCCCCCCC		57.8329967540
204PhosphorylationTTQMNEHSSRSHAIF
CCCCCCCCCCCCEEE		22.67-
288PhosphorylationLGDPRRKSSHIPYRD
HCCCCCCCCCCCHHH		25.9022210691
289PhosphorylationGDPRRKSSHIPYRDA
CCCCCCCCCCCHHHH		28.5922210691
297AcetylationHIPYRDAKITRLLKD
CCCHHHHHHHHHHHH		49.2319829927
303UbiquitinationAKITRLLKDSLGGSA
HHHHHHHHHHCCCCC		50.2729967540
305PhosphorylationITRLLKDSLGGSAKT
HHHHHHHHCCCCCEE		27.59-
316O-linked_GlycosylationSAKTVMITCVSPSSS
CCEEEEEEEECCCCC		6.6929351928
322PhosphorylationITCVSPSSSNFDESL
EEEECCCCCCHHHHH		32.46-
322O-linked_GlycosylationITCVSPSSSNFDESL
EEEECCCCCCHHHHH		32.4629351928
346PhosphorylationRNIRNKPTVNFSPES
HHCCCCCCCCCCCCC		29.6828258704
378PhosphorylationQSQQAGVSQTTQINR
HHCCCCCCCCCCCCC		22.38-
380PhosphorylationQQAGVSQTTQINREG
CCCCCCCCCCCCCCC		17.11-
381PhosphorylationQAGVSQTTQINREGS
CCCCCCCCCCCCCCC		21.58-
428PhosphorylationFLVDLKDTVRLNEKQ
HHHHHHHHCCCCHHH		13.1127251275
456PhosphorylationVRKAVLTSFRGIGGT
HHHHHHHHCCCCCCC		14.5824114839
525UbiquitinationKGHAVSLKEAQKVNR
CCCCCCHHHHHHHHH		43.4229967540
537UbiquitinationVNRLQNEKIIEQQLL
HHHHHCHHHHHHHHH		57.4429967540
560PhosphorylationTKLNLSVTSSAKENC
HHCCCCCCCCCHHHC		17.3724719451
561PhosphorylationKLNLSVTSSAKENCG
HCCCCCCCCCHHHCC		26.5824719451
607PhosphorylationDSRKVHTSPPMYSLD
CCCCCCCCCCCCCHH		16.4828258704
612PhosphorylationHTSPPMYSLDRIFAG
CCCCCCCCHHHHHHC		19.9728258704
643PhosphorylationKVLHCQFSDNSDDEE
CEEEEEECCCCCCCC		15.2525849741
646PhosphorylationHCQFSDNSDDEESEG
EEEECCCCCCCCCCC		51.9725849741
651PhosphorylationDNSDDEESEGQEKSG
CCCCCCCCCCCCCCC		45.0028450419
672PhosphorylationSWIQKPDSVCSLVEL
CCCCCCCCEEEEEEC		33.28-
675PhosphorylationQKPDSVCSLVELSDT
CCCCCEEEEEECCCC		33.04-
704PhosphorylationKIDCLQESQELNLQK
HHHHHHHHHHHCHHH		18.9227251275
711UbiquitinationSQELNLQKLKNSERI
HHHHCHHHHHHHHHH		65.6729967540
723UbiquitinationERILTEAKQKMRELT
HHHHHHHHHHHHHHH		44.1929967540
727MethylationTEAKQKMRELTINIK
HHHHHHHHHHHHCCC		42.69115368293
741UbiquitinationKMKEDLIKELIKTGN
CCCHHHHHHHHHHCC		54.4929967540
746PhosphorylationLIKELIKTGNDAKSV
HHHHHHHHCCCCCCH		33.9326657352
752PhosphorylationKTGNDAKSVSKQYSL
HHCCCCCCHHHHHCE		33.0926657352
757PhosphorylationAKSVSKQYSLKVTKL
CCCHHHHHCEEEEEC		21.5126657352
758PhosphorylationKSVSKQYSLKVTKLE
CCHHHHHCEEEEECC		21.1524719451
772AcetylationEHDAEQAKVELIETQ
CCCHHHHHHHHHHHH		35.6219827577
780UbiquitinationVELIETQKQLQELEN
HHHHHHHHHHHHHCC		61.4729967540
840UbiquitinationQNEKRANELEQSVDH
HCHHHHHHHHHHHHH		53.3429967540
852UbiquitinationVDHMKYQKIQLQRKL
HHHHHHHHHHHHHHH		29.3629967540
868UbiquitinationEENEKRKQLDAVIKR
HHHHHHHHHHHHHHH		48.9129967540
887PhosphorylationIKEIQLKTGQEEGLK
HHHHCCHHCCCCCCC		53.3328509920
904UbiquitinationAEDLDACNLKRRKGS
HHHCCCCCCCCCCCC		50.7729967540
906UbiquitinationDLDACNLKRRKGSFG
HCCCCCCCCCCCCCC		35.8429967540
911PhosphorylationNLKRRKGSFGSIDHL
CCCCCCCCCCCHHHH		29.4825159151
914PhosphorylationRRKGSFGSIDHLQKL
CCCCCCCCHHHHHHH		23.8828450419
934UbiquitinationWLDEEVEKVLNQRQE
HHHHHHHHHHHHHHH		58.1429967540
935UbiquitinationLDEEVEKVLNQRQEL
HHHHHHHHHHHHHHH		3.7229967540
958MethylationKREAIVSKKEALLQE
HHHHHHCHHHHHHHH		43.68-
976PhosphorylationLENKKLRSSQALNTD
HCCHHHCCCCCCCCC		36.9228348404
977PhosphorylationENKKLRSSQALNTDS
CCHHHCCCCCCCCCH		17.0328348404
999PhosphorylationNLLEQELSEKNVQLQ
HHHHHHHHHHCCCCC		45.85-
1001UbiquitinationLEQELSEKNVQLQTS
HHHHHHHHCCCCCCC		60.0729967540
1062UbiquitinationLFQLEEGIEALEAAI
HEEHHHHHHHHHHHH		2.9529967540
1071PhosphorylationALEAAIEYRNESIQN
HHHHHHHHHHHHHHH		16.78-
1079UbiquitinationRNESIQNRQKSLRAS
HHHHHHHHHHHHHHH		29.0029967540
1082PhosphorylationSIQNRQKSLRASFHN
HHHHHHHHHHHHHHC		18.1028348404
1086PhosphorylationRQKSLRASFHNLSRG
HHHHHHHHHHCCCCC		22.1728348404
1093UbiquitinationSFHNLSRGEANVLEK
HHHCCCCCCHHHHHH		34.6929967540
1105UbiquitinationLEKLACLSPVEIRTI
HHHHHCCCHHHHHHH		27.1229967540
1110UbiquitinationCLSPVEIRTILFRYF
CCCHHHHHHHHHHHH		11.3829967540
1136UbiquitinationKQQLYNEEMKMKVLE
HHHHCCHHHHHHHHH		40.2329967540
1159UbiquitinationESALDHLKLQCDRRL
HHHHHHHHHHCHHCC		32.8429967540
1176UbiquitinationQQKEHEQKMQLLLHH
HHHHHHHHHHHHHHH		26.1529967540
1202UbiquitinationTFKTYEDKIQQLEKD
HHHHHHHHHHHHHHH		30.4029967540
1239PhosphorylationIRRQLAPSEYQEAGD
HHHHHCCHHHHHCCC		43.24-
1260UbiquitinationGGGMLSEELKWASRP
CCCCCCHHHHHCCCC		52.8829967540
1281PhosphorylationGREREMDSSASSLRT
CCCHHCCCCHHHCCC		26.88-
1282PhosphorylationREREMDSSASSLRTQ
CCHHCCCCHHHCCCC		28.10-
1284PhosphorylationREMDSSASSLRTQPN
HHCCCCHHHCCCCCC		31.67-
1285PhosphorylationEMDSSASSLRTQPNP
HCCCCHHHCCCCCCH		22.91-
1291UbiquitinationSSLRTQPNPQKLWED
HHCCCCCCHHHHHCC		41.6429967540
1338PhosphorylationTKSHSRLSSQIQVVG
HHHHHHHHHHEEEEE		21.0620363803
1339PhosphorylationKSHSRLSSQIQVVGN
HHHHHHHHHEEEEEC		35.5820363803
1357UbiquitinationLHGVTPVKLCRKELR
HCCCCHHHHCHHHHH		42.9729967540
1367PhosphorylationRKELRQISALELSLR
HHHHHHHHHHHHHHH		20.6129083192
1372PhosphorylationQISALELSLRRSSLG
HHHHHHHHHHHHCCC		15.5124247654
1376PhosphorylationLELSLRRSSLGVGIG
HHHHHHHHCCCCCCC		24.3928348404
1377PhosphorylationELSLRRSSLGVGIGS
HHHHHHHCCCCCCCH		27.6028348404
1384PhosphorylationSLGVGIGSMAADSIE
CCCCCCCHHHHHHEE		11.8822210691
1389PhosphorylationIGSMAADSIEVSRKP
CCHHHHHHEEECCCC		18.87-
1393PhosphorylationAADSIEVSRKPRDLK
HHHHEEECCCCCCCC		23.0722210691
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KIF27_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KIF27_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KIF27_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of KIF27_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KIF27_HUMAN

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Related Literatures of Post-Translational Modification

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