dbPTM

KI2S1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KI2S1_HUMAN
UniProt AC	Q14954
Protein Name	Killer cell immunoglobulin-like receptor 2DS1 {ECO:0000305}
Gene Name	KIR2DS1 {ECO:0000312\|HGNC:HGNC:6333}
Organism	Homo sapiens (Human).
Sequence Length	304
Subcellular Localization	Cell membrane Single-pass type I membrane protein Extracellular side .
Protein Description	Receptor on natural killer (NK) cells for some HLA-C alleles such as w6. Does not inhibit the activity of NK cells..
Protein Sequence	MSLTVVSMACVGFFLLQGAWPHEGVHRKPSLLAHPGRLVKSEETVILQCWSDVMFEHFLLHREGMFNDTLRLIGEHHDGVSKANFSISRMKQDLAGTYRCYGSVTHSPYQLSAPSDPLDIVIIGLYEKPSLSAQPGPTVLAGENVTLSCSSRSSYDMYHLSREGEAHERRLPAGTKVNGTFQANFPLGPATHGGTYRCFGSFRDSPYEWSKSSDPLLVSVTGNPSNSWPSPTEPSSETGNPRHLHVLIGTSVVKIPFTILLFFLLHRWCSDKKNAAVMDQEPAGNRTVNSEDSDEQDHQEVSYA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLTVVSMA ------CCCCHHHHH	32.52	26074081
4	Phosphorylation	----MSLTVVSMACV ----CCCCHHHHHHH	16.14	26074081
30	Phosphorylation	EGVHRKPSLLAHPGR CCCCCCHHHHCCCCC	38.76	24719451
51	Phosphorylation	TVILQCWSDVMFEHF EEEEHHHHHHHHHHH	28.14	-
67	N-linked_Glycosylation	LHREGMFNDTLRLIG HHCCCCCHHHHHHHH	32.25	UniProtKB CARBOHYD
84	N-linked_Glycosylation	HDGVSKANFSISRMK CCCCCCCCEEHHHHH	34.63	UniProtKB CARBOHYD
98	Phosphorylation	KQDLAGTYRCYGSVT HHHHCCCEEEEEEEC	9.58	-
109	Phosphorylation	GSVTHSPYQLSAPSD EEECCCCCCCCCCCC	25.71	18083107
144	N-linked_Glycosylation	PTVLAGENVTLSCSS CEEECCCCEEEEECC	31.02	UniProtKB CARBOHYD
178	N-linked_Glycosylation	LPAGTKVNGTFQANF CCCCCEECCEEEECC	45.39	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KI2S1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KI2S1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KI2S1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of KI2S1_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KI2S1_HUMAN

Related Literatures of Post-Translational Modification