| UniProt ID | KI2LA_HUMAN | |
|---|---|---|
| UniProt AC | Q8N109 | |
| Protein Name | Killer cell immunoglobulin-like receptor 2DL5A | |
| Gene Name | KIR2DL5A | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 375 | |
| Subcellular Localization |
Cell membrane Single-pass type I membrane protein. |
|
| Protein Description | Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.. | |
| Protein Sequence | MSLMVISMACVGFFLLQGAWTHEGGQDKPLLSAWPSAVVPRGGHVTLLCRSRLGFTIFSLYKEDGVPVPELYNKIFWKSILMGPVTPAHAGTYRCRGSHPRSPIEWSAPSNPLVIVVTGLFGKPSLSAQPGPTVRTGENVTLSCSSRSSFDMYHLSREGRAHEPRLPAVPSVNGTFQADFPLGPATHGGTYTCFGSLHDSPYEWSDPSDPLLVSVTGNSSSSSSSPTEPSSKTGIRRHLHILIGTSVAIILFIILFFFLLHCCCSNKKNAAVMDQEPAGDRTVNREDSDDQDPQEVTYAQLDHCVFTQTKITSPSQRPKTPPTDTTMYMELPNAKPRSLSPAHKHHSQALRGSSRETTALSQNRVASSHVPAAGI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 92 | Phosphorylation | VTPAHAGTYRCRGSH CCCCCCCCEECCCCC | 14.47 | - | |
| 93 | Phosphorylation | TPAHAGTYRCRGSHP CCCCCCCEECCCCCC | 13.54 | - | |
| 139 | N-linked_Glycosylation | PTVRTGENVTLSCSS CEEECCCCEEEEECC | 33.16 | UniProtKB CARBOHYD | |
| 141 | Phosphorylation | VRTGENVTLSCSSRS EECCCCEEEEECCCC | 25.24 | - | |
| 148 | Phosphorylation | TLSCSSRSSFDMYHL EEEECCCCCCCCEEC | 36.99 | - | |
| 149 | Phosphorylation | LSCSSRSSFDMYHLS EEECCCCCCCCEECC | 24.93 | - | |
| 153 | Phosphorylation | SRSSFDMYHLSREGR CCCCCCCEECCCCCC | 11.06 | - | |
| 173 | N-linked_Glycosylation | LPAVPSVNGTFQADF CCCCCCCCCEEEECC | 48.39 | UniProtKB CARBOHYD | |
| 218 | N-linked_Glycosylation | LLVSVTGNSSSSSSS EEEEEECCCCCCCCC | 29.38 | UniProtKB CARBOHYD | |
| 298 | Phosphorylation | QDPQEVTYAQLDHCV CCHHHCHHHCCCEEE | 9.49 | - | |
| 320 | Phosphorylation | SPSQRPKTPPTDTTM CHHHCCCCCCCCCEE | 36.86 | 24850871 | |
| 323 | Phosphorylation | QRPKTPPTDTTMYME HCCCCCCCCCEEEEE | 47.37 | 26434552 | |
| 326 | Phosphorylation | KTPPTDTTMYMELPN CCCCCCCEEEEECCC | 14.76 | 26434552 | |
| 328 | Phosphorylation | PPTDTTMYMELPNAK CCCCCEEEEECCCCC | 5.83 | 27642862 | |
| 367 | Phosphorylation | LSQNRVASSHVPAAG HHHCCCHHCCCCCCC | 20.37 | 29449344 | |
| 368 | Phosphorylation | SQNRVASSHVPAAGI HHCCCHHCCCCCCCC | 20.83 | 29449344 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KI2LA_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KI2LA_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KI2LA_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of KI2LA_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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