KI26A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KI26A_HUMAN
• UniProt AC: Q9ULI4
• Protein Name: Kinesin-like protein KIF26A
• Gene Name: KIF26A
• Organism: Homo sapiens (Human).
• Sequence Length: 1882
• Subcellular Localization: Cytoplasm, cytoskeleton .
• Protein Description: Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity)..
• Protein Sequence: MVGRGVPLCAAQPAVAEGGPAREPPPLLEVSPRKRLPAGPDQDPCGSRPAPEGAGAGPEQGHSAGGGGWCRHCHTKLVELKRQAWKLVSGPGTTLRDPCLSALLLDKLPAPGALPACRPEAERRCDVCATHLQQLTREAMHLLQAPASHEDLDAPHGGPSLAPPSTTTSSRDTPGPAGPAGRQPGRAGPDRTKGLAWSPGPSVQVSVAPAGLGGALSTVTIQAQQCLEGMWSVSRVNSFLPPACLAEAAVAAVAVADTVRECPPVAGPDGLSKAWGRGGVCTSALVTPTPGSVGGSTGPSAAASFFIRAMQKLSLASKRKKPHPPPPPATRGTSTYPTDFSGVLQLWPPPAPPCLLRAASKTKDNPGSIGKVKVMLRIWPAQGAQRSAEAMSFLKVDPRKKQVILYDPAAGPPGSAGPRRAATAAVPKMFAFDAVFPQDSEQAEVCSGTVADVLQSVVSGADGCIFSFGHMSLGKSYTMIGKDSSPQSLGIVPCAISWLFRLIEERRERTGTRFSVRVSAVEVCGRDQSLRDLLAEVAPGSLQDTQSPGVYLREDPVCGAQLQNQSELRAPTAEKAAFYLDAALAARSTSRAGCGEDARRSSHMLFTLHVYQYRMEKCGRGGMSGGRSRLHLIDLGSCEAAAGRAGEAAGGPLCLSLSALGSVILALVNGAKHVPYRDHRLTMLLRESLATAGCRTTMIAHVSDAPAQHAETLSTVQLAARIHRLRRKKAKYASSSSGGESSCEEGRARRPPHLRPFHPRTVALDPDRTPPCLPGDPDYSSSSEQSCDTVIYVGPGGAALSDRELTDNEGPPDFVPIIPALSRHRPSKGPRDADHFRCSTFAELQERLECMDGNEGPSGGPGGTDGAQASPARGGRKPSPPEAASPRKAVGTPMAASTPRGSSGPDTHQGTPEPCKAIVWGDQREDSSAWPELLVPEKAAVSGGRRPLPSPAPPPPQLLEACRAPEEPGGGGTDGVARTPPVGMSGQVAGSPMLPGATCPRLAAGSRCPERGLLTTTVTLQRPVELNGEDELVFTVVEELSLGALAGAGRPTSLASFDSDCSLRALASGSRPVSIISSINDEFDAYTSQAPEGGPLEGAAWAGSSHGSSISSWLSEVSVCTADSRDPTPQPRFSPDSLAGLDPGGPPALDGSLGDGSSGFLGPDRPDSPGPTWGPCPGEVAAVAPSRPGREPQAGPSRWASAAQTIHSSLPRKPRTASATTRVGCARLGQSPPGRGGLFEDPWLLRVGECDTQAASAGRAPSPTLGSPRLPEAQVMLACAQRVVDGCEVAARAARRPEAVARIPPLRRGATTLGVTTPAVSWGDAPTEVVACSGSLKASPTSKKGLAPKAGFLPRPSGAAPPAPPTRKSSLEQRSSPASAPPHAVNPARVGAAAVLRGEEEPRPSSRADHSVPRATSSLKARASKVEAAHRLAGHASLERYEGLAHSSSKGREAPGRPPRAVPKLGVPPSSPTHGPAPACRSGAAKAVGAPKPPVGGGKGRGLVAGGSRALGPSVKLSTASVTGRSPGGPVAGPRAAPRAGPSVGAKAGRGTVMGTKQALRAAHSRVHELSASGAPGRGGSSWGSADSDSGHDSGVNVGEERPPTGPALPSPYSKVTAPRRPQRYSSGHGSDNSSVLSGELPPAMGRTALFHHSGGSSGYESLRRDSEATGSASSAPDSMSESGAASPGARTRSLKSPKKRATGLQRRRLIPAPLPDTTALGRKPSLPGQWVDLPPPLAGSLKEPFEIKVYEIDDVERLQRPRPTPREAPTQGLACVSTRLRLAERRQQRLREVQAKHKHLCEELAETQGRLMLEPGRWLEQFEVDPELEPESAEYLAALERATAALEQCVNLCKAHVMMVTCFDISVAASAAIPGPQEVDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Methylation	----MVGRGVPLCAA ----CCCCCCCCCCC	48.39	30987755
31	Phosphorylation	PPPLLEVSPRKRLPA CCCCEECCCCCCCCC	15.04	23663014
93	Phosphorylation	KLVSGPGTTLRDPCL HHHCCCCCCCCCHHH	26.28	23917254
273	Ubiquitination	AGPDGLSKAWGRGGV CCCCCCHHHHCCCCC	53.88	-
283	Phosphorylation	GRGGVCTSALVTPTP CCCCCCCEEEECCCC	17.93	22210691
292	Phosphorylation	LVTPTPGSVGGSTGP EECCCCCCCCCCCCH	20.84	22210691
300	Phosphorylation	VGGSTGPSAAASFFI CCCCCCHHHHHHHHH	31.70	22210691
312	Ubiquitination	FFIRAMQKLSLASKR HHHHHHHHHHHHHCC	27.27	-
320	Ubiquitination	LSLASKRKKPHPPPP HHHHHCCCCCCCCCC	74.52	-
321	Ubiquitination	SLASKRKKPHPPPPP HHHHCCCCCCCCCCC	53.22	-
330	Phosphorylation	HPPPPPATRGTSTYP CCCCCCCCCCCCCCC	35.09	20446291
368	Phosphorylation	KTKDNPGSIGKVKVM CCCCCCCCCCEEEEE	29.44	29802988
392	Phosphorylation	QRSAEAMSFLKVDPR HHHHHHHHCCCCCCC	34.18	25159151
395	Ubiquitination	AEAMSFLKVDPRKKQ HHHHHCCCCCCCCCE	42.45	-
401	Ubiquitination	LKVDPRKKQVILYDP CCCCCCCCEEEEECC	51.59	29967540
406	Phosphorylation	RKKQVILYDPAAGPP CCCEEEEECCCCCCC	14.57	-
476	Phosphorylation	GHMSLGKSYTMIGKD CCCCCCCEEEEECCC	24.84	24719451
515	Phosphorylation	ERTGTRFSVRVSAVE HHHCCCEEEEEEEEE	13.01	29457462
575	Ubiquitination	LRAPTAEKAAFYLDA HCCCCHHHHHHHHHH	42.42	-
586	Phosphorylation	YLDAALAARSTSRAG HHHHHHHHHHHCCCC	13.55	17081983
588	Phosphorylation	DAALAARSTSRAGCG HHHHHHHHHCCCCCC	26.47	-
628	Phosphorylation	GGMSGGRSRLHLIDL CCCCCCCCCEEEEEH	42.33	17081983
732	Phosphorylation	LRRKKAKYASSSSGG HHHHHCHHCCCCCCC	19.31	-
761	Phosphorylation	LRPFHPRTVALDPDR CCCCCCCEEECCCCC	18.00	-
769	Phosphorylation	VALDPDRTPPCLPGD EECCCCCCCCCCCCC	38.67	23403867
786	Phosphorylation	YSSSSEQSCDTVIYV CCCCCCCCCCEEEEE	15.20	23403867
789	Phosphorylation	SSEQSCDTVIYVGPG CCCCCCCEEEEECCC	17.09	23403867
806	Phosphorylation	ALSDRELTDNEGPPD CCCCHHCCCCCCCCC	31.84	20873877
847	Methylation	TFAELQERLECMDGN HHHHHHHHHHCCCCC	23.87	115389321
864	Phosphorylation	PSGGPGGTDGAQASP CCCCCCCCCCCCCCC	36.86	27732954
870	Phosphorylation	GTDGAQASPARGGRK CCCCCCCCCCCCCCC	13.65	25159151
879	Phosphorylation	ARGGRKPSPPEAASP CCCCCCCCCCCCCCC	57.00	30266825
885	Phosphorylation	PSPPEAASPRKAVGT CCCCCCCCCCCCCCC	32.08	23663014
892	Phosphorylation	SPRKAVGTPMAASTP CCCCCCCCCCCCCCC	11.86	27732954
897	Phosphorylation	VGTPMAASTPRGSSG CCCCCCCCCCCCCCC	29.43	27732954
898	Phosphorylation	GTPMAASTPRGSSGP CCCCCCCCCCCCCCC	16.57	27732954
911	Phosphorylation	GPDTHQGTPEPCKAI CCCCCCCCCCCCEEE	20.22	25159151
916	Ubiquitination	QGTPEPCKAIVWGDQ CCCCCCCEEEEECCC	52.44	29967540
973	Phosphorylation	EEPGGGGTDGVARTP CCCCCCCCCCCCCCC	32.62	22210691
979	Phosphorylation	GTDGVARTPPVGMSG CCCCCCCCCCCCCCC	23.39	27732954
985	Phosphorylation	RTPPVGMSGQVAGSP CCCCCCCCCEECCCC	21.83	27251275
991	Phosphorylation	MSGQVAGSPMLPGAT CCCEECCCCCCCCCC	9.44	22210691
998	Phosphorylation	SPMLPGATCPRLAAG CCCCCCCCCCHHCCC	29.02	27251275
1052	Phosphorylation	LAGAGRPTSLASFDS HCCCCCCCCHHHCCC	34.70	24260401
1056	Phosphorylation	GRPTSLASFDSDCSL CCCCCHHHCCCCCHH	34.57	23663014
1059	Phosphorylation	TSLASFDSDCSLRAL CCHHHCCCCCHHHHH	38.21	23663014
1062	Phosphorylation	ASFDSDCSLRALASG HHCCCCCHHHHHHCC	26.36	23663014
1068	Phosphorylation	CSLRALASGSRPVSI CHHHHHHCCCCCEEE	37.84	26074081
1070	Phosphorylation	LRALASGSRPVSIIS HHHHHCCCCCEEEEE	30.80	26074081
1074	Phosphorylation	ASGSRPVSIISSIND HCCCCCEEEEECCCC	19.52	26074081
1077	Phosphorylation	SRPVSIISSINDEFD CCCEEEEECCCCCCH	24.40	26074081
1078	Phosphorylation	RPVSIISSINDEFDA CCEEEEECCCCCCHH	18.27	26074081
1086	Phosphorylation	INDEFDAYTSQAPEG CCCCCHHHHCCCCCC	14.58	26074081
1201	Phosphorylation	AGPSRWASAAQTIHS CCCCHHHHHHHHHHH	19.71	23403867
1205	Phosphorylation	RWASAAQTIHSSLPR HHHHHHHHHHHCCCC	18.87	23403867
1208	Phosphorylation	SAAQTIHSSLPRKPR HHHHHHHHCCCCCCC	29.71	23403867
1209	Phosphorylation	AAQTIHSSLPRKPRT HHHHHHHCCCCCCCC	28.38	23403867
1231	Phosphorylation	GCARLGQSPPGRGGL CHHHCCCCCCCCCCC	31.12	22617229
1252	Phosphorylation	LRVGECDTQAASAGR EEEECCCHHHHHCCC	31.59	23312004
1256	Phosphorylation	ECDTQAASAGRAPSP CCCHHHHHCCCCCCC	33.98	23312004
1262	Phosphorylation	ASAGRAPSPTLGSPR HHCCCCCCCCCCCCC	29.54	30266825
1264	Phosphorylation	AGRAPSPTLGSPRLP CCCCCCCCCCCCCCC	48.35	30266825
1267	Phosphorylation	APSPTLGSPRLPEAQ CCCCCCCCCCCCHHH	15.23	23663014
1312	Phosphorylation	PLRRGATTLGVTTPA CCCCCCCCCCCCCCC	22.45	-
1327	Phosphorylation	VSWGDAPTEVVACSG CCCCCCCCEEEEEEC	43.03	-
1357	Phosphorylation	AGFLPRPSGAAPPAP CCCCCCCCCCCCCCC	42.20	26657352
1366	Phosphorylation	AAPPAPPTRKSSLEQ CCCCCCCCCCCCCHH	50.06	26434776
1375	Phosphorylation	KSSLEQRSSPASAPP CCCCHHHCCCCCCCC	40.13	25627689
1376	Phosphorylation	SSLEQRSSPASAPPH CCCHHHCCCCCCCCC	27.03	25627689
1379	Phosphorylation	EQRSSPASAPPHAVN HHHCCCCCCCCCCCC	44.70	27732954
1405	Phosphorylation	GEEEPRPSSRADHSV CCCCCCCCCCCCCCC	33.46	29083192
1406	Phosphorylation	EEEPRPSSRADHSVP CCCCCCCCCCCCCCC	33.88	29083192
1425	Ubiquitination	SLKARASKVEAAHRL HHHHHHHHHHHHHHH	43.01	29967540
1437	Phosphorylation	HRLAGHASLERYEGL HHHHCCCCHHHHCCC	25.70	30266825
1441	Phosphorylation	GHASLERYEGLAHSS CCCCHHHHCCCCCCC	12.65	23312004
1447	Phosphorylation	RYEGLAHSSSKGREA HHCCCCCCCCCCCCC	30.60	23312004
1448	Phosphorylation	YEGLAHSSSKGREAP HCCCCCCCCCCCCCC	26.63	27251275
1449	Phosphorylation	EGLAHSSSKGREAPG CCCCCCCCCCCCCCC	41.99	27251275
1470	Phosphorylation	PKLGVPPSSPTHGPA CCCCCCCCCCCCCCC	42.77	25627689
1471	Phosphorylation	KLGVPPSSPTHGPAP CCCCCCCCCCCCCCC	39.32	25159151
1473	Phosphorylation	GVPPSSPTHGPAPAC CCCCCCCCCCCCCCC	41.22	23312004
1508	Phosphorylation	RGLVAGGSRALGPSV CCCCCCCCCCCCCCE	17.29	-
1514	Phosphorylation	GSRALGPSVKLSTAS CCCCCCCCEEEEECE	30.04	-
1526	Phosphorylation	TASVTGRSPGGPVAG ECEEECCCCCCCCCC	29.28	28674419
1543	Phosphorylation	AAPRAGPSVGAKAGR CCCCCCCCCCCCCCC	32.06	30576142
1552	Phosphorylation	GAKAGRGTVMGTKQA CCCCCCCCCCCHHHH	13.12	-
1556	Phosphorylation	GRGTVMGTKQALRAA CCCCCCCHHHHHHHH	11.24	-
1557	Ubiquitination	RGTVMGTKQALRAAH CCCCCCHHHHHHHHH	28.04	-
1571	Phosphorylation	HSRVHELSASGAPGR HHHHHHHHCCCCCCC	19.87	25627689
1621	Dimethylation	SKVTAPRRPQRYSSG CCCCCCCCCCCCCCC	30.55	-
1621	Methylation	SKVTAPRRPQRYSSG CCCCCCCCCCCCCCC	30.55	24380937
1647	Dimethylation	ELPPAMGRTALFHHS CCCCCCCCEEEEECC	12.07	-
1647	Methylation	ELPPAMGRTALFHHS CCCCCCCCEEEEECC	12.07	24380947
1657	Phosphorylation	LFHHSGGSSGYESLR EEECCCCCCHHHHHH	24.90	-
1658	Phosphorylation	FHHSGGSSGYESLRR EECCCCCCHHHHHHC	48.98	-
1660	Phosphorylation	HSGGSSGYESLRRDS CCCCCCHHHHHHCCC	12.32	25884760
1662	Phosphorylation	GGSSGYESLRRDSEA CCCCHHHHHHCCCCC	20.77	23186163
1670	Phosphorylation	LRRDSEATGSASSAP HHCCCCCCCCCCCCC	27.84	22210691
1674	Phosphorylation	SEATGSASSAPDSMS CCCCCCCCCCCCHHC	28.82	22210691
1679	Phosphorylation	SASSAPDSMSESGAA CCCCCCCHHCCCCCC	24.13	25907765
1681	Phosphorylation	SSAPDSMSESGAASP CCCCCHHCCCCCCCC	32.34	27732954
1683	Phosphorylation	APDSMSESGAASPGA CCCHHCCCCCCCCCC	26.82	27732954
1687	Phosphorylation	MSESGAASPGARTRS HCCCCCCCCCCCCCC	24.27	27732954
1697	Phosphorylation	ARTRSLKSPKKRATG CCCCCCCCHHHCCCC	47.44	24719451
1726	Phosphorylation	TALGRKPSLPGQWVD CCCCCCCCCCCCCCC	50.67	24117733
1751	Phosphorylation	EPFEIKVYEIDDVER CCEEEEEEEECCHHH	11.36	25884760

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KI26A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KI26A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KI26A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of KI26A_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-628, AND MASSSPECTROMETRY.
PubMed: 17081983