dbPTM

KDM5_CAEEL - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KDM5_CAEEL
UniProt AC	Q23541
Protein Name	Lysine-specific demethylase rbr-2
Gene Name	rbr-2
Organism	Caenorhabditis elegans.
Sequence Length	1477
Subcellular Localization	Nucleus .
Protein Description	Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. [PubMed: 17320161 Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20']
Protein Sequence	MRARRQENSISTPSAPSTSTSPRKKASIGNSRSKNHGSKMEMYDQFYKKFVRPPMAPIYYPTEEEFSDPIEYVAKIRHEAEKFGVVKIVPPANFKPPFAIDKEAFTFRPRTQKLNEVEAIVKEKHTFIDRLINFNRYSGLTFEFPVDRDGNIVDLYRLHRIVQNFGGCEEVNEDEKWRDVAREYLPKEQMARGVPSAFINLIRSHYNLHIEPFNRNLKEKAMKNDDESDDEMEELKHKYQHHHGTMRTEIEVPNDKTTEGGEDECPVSMQSGRRRSKNKKASSSRKTLGTSSKKNSTRGRKNKKKAEGDDDDDEDPMDQVFCVACNEGKDEDLLLLCDIDGCNNGRHTYCCDPVLDEVPEGEWRCPKCIESEDAKIGLDWGFYDADTEYNLNSFTEFANKWKCDYFGVKDVSQVSCDAVERSFWKNVISHENPVSVKYGADLITSRVGSGFPRKEDKHTGPDLKLKQQYASHAWNLNNMPVLRESVLSHFNTGISGMMVPWVYVGMCFSTFCWHTEDHWTYSVNYNHFGERKIWYGVGGEDAEKFEDALKKIAPGLTGRQRDLFHHMTTAANPHLLRSLGVPIHSVHQNAGEFVITFPRAYHAGFNEGLNFAEAVNFAPIDWLSKGRECVESYSNVRRYLVFSHDELLFKMVEAMDKLGISMSLATHEELIRIYEKQKMLRELLARLGVSNRQMQQVMFEKIPDEQRSCRFCKTTLFMCALVCNKHKKMTCVEHHDHLCNSCTTKDYRYQYRFELDQLNNMCDELGKRTVNYNGWKEESDEMLEEEGKPKLERIEEFIDSAKQNKYPQTDQVHKLITIRHTAKSAIEKANQLLFKKVRTRTKTRCQRADTRTDTEGVRSLIEQMQAMDCNLTVIIDKLEKWMEQVEMWRNRAKDAIYREQEYSKEEIEKIIEEGDEYDIKLEEIDELRKVIQMKDWSDRARKVTTWKATPDMEKDIDFEYKLRYASSDILSLIRDSPRNPTDGTSKLVFELQQMLRDANTLEVIANNFCENPALDQLQSIWQSLRETDWFYEKYINMVRYEIIHVAKIKSMIDAAIPVLSEFDLKTQLQKIVNVEITLSKAAEISKAFETSKCLNGSEEHLGILDMISTMNAFTQRIAILFKPNNAYHNLFEILSERDDLTPLAEGQTIPLYFQGGAVHPSDEWHQMKEFESLDQIVHHQSSLREMQMRIFEKVKQANSARGLEACSCLGFNKSDDSESTLTCIMCDSEFHVRCCEWSPFLEKLPEGCFLCVRCLRGQRPVIDDVTTALNGTPSGCLETHLVRNLIQKTRGITQNLMEAANKRKSGESSDDICKIALFDWLSCEILNPNGLPKARELISEFYMEYLQKQSSAALELKNRPVRSKPSVSLFDPKITAKRKRPSVSHKETSKKSRKRQSQASPSEYYEDESEFKSCQARACLKPYGDSVNWVMCEAGCKNWFHVICLGFTLREINDMHEYRCSSCLDHADSPTSSVSTD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
228	Phosphorylation	AMKNDDESDDEMEEL HHCCCCCCHHHHHHH	58.31	30078680

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KDM5_CAEEL !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KDM5_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KDM5_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of KDM5_CAEEL !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KDM5_CAEEL

Related Literatures of Post-Translational Modification