KDM4B_MOUSE - dbPTM
KDM4B_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KDM4B_MOUSE
UniProt AC Q91VY5
Protein Name Lysine-specific demethylase 4B
Gene Name Kdm4b
Organism Mus musculus (Mouse).
Sequence Length 1086
Subcellular Localization Nucleus .
Protein Description Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (By similarity)..
Protein Sequence MGSEDHSAQNPSCKIMTFRPTMDEFRDFNRYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGNLRTILDMVERECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPERYEQWKQGRDLTVLDHTRPTALSSPELSSWSASRTSIKAKLLRRQISVKESRPWRKAEEERRREPTRRPGPASHRRRSQPKKSKPEESRSPGEATAGVSTLDEARGCSRGEAMPEDEEEEELLPSQGHEAEGVEEDGRGKPRPTKARNKKKTPSPSSPPLLSAPPALFPTEEVLRPPPQPKSPGPAMGPMAAEGGPPPTPLNVVPPGAPVEEAEVRPRPIIPMLYVLPRTSSTDGDREHSAHAQLAPMELGPEEENQAQAGDSQGTTPFSKLKVEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEAFLFSGEDDVTDPEALRSLLSLQWKNKAASFQAERKFNAAAALSEPYCAICTLFYPYSQSVQTERDSAVQPPSKSGQRTRPLIPEMCFTSSGENTEPLPANSYVGEDGTSPLISCAHCCLQVHASCYGVRPELAKEGWTCSRCAAHAWTAECCLCNLRGGALQRTTEHRWIHVICAIAVPEVRFLNVIERNPVDVSAIPEQRWKLKCIYCRKRMKRVSGACIQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVSITCLKHRASGAGGQLLRTVSLGQIVITKNRNGLYYRCRVIGTTAQTFYEVNFDDGSYSDNLYPESITSRDCLRLGPPPEGELVELRWTDGNLYRARFISMATSLIYQVEFEDGSQLTVKRGDIFTLEEELPKRVRSRLSLSTGTPQEPSFSGDDVKAAKRPRVASVLATTTEDTGRSPEYLSFMESLLQAQGRPGAPF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
305PhosphorylationIDYGKVATQCTCRKD
EEHHHEECEEEECHH		27.4517203969
317PhosphorylationRKDMVKISMDVFVRI
CHHHEEEEHHHHHHH		11.8320531401
375PhosphorylationKLLRRQISVKESRPW
HHHHHCCCCCCCCCC		20.85-
394PhosphorylationEERRREPTRRPGPAS
HHHHCCCCCCCCCHH		34.2623140645
401PhosphorylationTRRPGPASHRRRSQP
CCCCCCHHHCCCCCC		22.2122817900
411PhosphorylationRRSQPKKSKPEESRS
CCCCCCCCCCHHHCC		60.6225619855
416PhosphorylationKKSKPEESRSPGEAT
CCCCCHHHCCCCCCC		36.0725619855
418PhosphorylationSKPEESRSPGEATAG
CCCHHHCCCCCCCCC		46.6827149854
423PhosphorylationSRSPGEATAGVSTLD
HCCCCCCCCCCCHHH		21.4625619855
427PhosphorylationGEATAGVSTLDEARG
CCCCCCCCHHHHHCC		23.4925619855
428PhosphorylationEATAGVSTLDEARGC
CCCCCCCHHHHHCCC		35.5025619855
453PhosphorylationEEEELLPSQGHEAEG
HHHHHCCCCCCCCCC		49.0822006019
480PhosphorylationKARNKKKTPSPSSPP
CCCCCCCCCCCCCCC		37.5726643407
482PhosphorylationRNKKKTPSPSSPPLL
CCCCCCCCCCCCCCC		42.5226643407
484PhosphorylationKKKTPSPSSPPLLSA
CCCCCCCCCCCCCCC		60.8726643407
485PhosphorylationKKTPSPSSPPLLSAP
CCCCCCCCCCCCCCC		33.6425266776
490PhosphorylationPSSPPLLSAPPALFP
CCCCCCCCCCCCCCC		46.5426643407
498PhosphorylationAPPALFPTEEVLRPP
CCCCCCCCHHHCCCC		37.1322817900
510PhosphorylationRPPPQPKSPGPAMGP
CCCCCCCCCCCCCCC		41.6026643407
558 (in isoform 2)Phosphorylation-25.7025338131
558PhosphorylationMLYVLPRTSSTDGDR
EEEEEECCCCCCCCC		25.7025338131
560 (in isoform 2)Phosphorylation-29.8825338131
568PhosphorylationTDGDREHSAHAQLAP
CCCCCCCCCCCEECC		19.5925338131
599AcetylationQGTTPFSKLKVEIKK
CCCCCHHHHEEEEEH		53.35-
617PhosphorylationHPLGRPPTRSPLSVV
CCCCCCCCCCCCHHH		46.6026060331
619PhosphorylationLGRPPTRSPLSVVKQ
CCCCCCCCCCHHHEE		32.4426239621
622PhosphorylationPPTRSPLSVVKQEAS
CCCCCCCHHHEECCC		28.4026239621
629PhosphorylationSVVKQEASSDEEAFL
HHHEECCCCCCCCEE		37.2526239621
630PhosphorylationVVKQEASSDEEAFLF
HHEECCCCCCCCEEE		56.9726239621
638PhosphorylationDEEAFLFSGEDDVTD
CCCCEEECCCCCCCC		43.3425293948
908PhosphorylationGQLLRTVSLGQIVIT
CCEEEEEECCCEEEE		26.6026239621
1024PhosphorylationELPKRVRSRLSLSTG
HHCHHHHHHHCCCCC		34.4125338131
1027PhosphorylationKRVRSRLSLSTGTPQ
HHHHHHHCCCCCCCC		21.11-
1037PhosphorylationTGTPQEPSFSGDDVK
CCCCCCCCCCCHHHH		31.1526745281
1039PhosphorylationTPQEPSFSGDDVKAA
CCCCCCCCCHHHHHH		45.7226745281
1053PhosphorylationAKRPRVASVLATTTE
HCCCCEEEEEEEECC		18.1425266776
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KDM4B_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KDM4B_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KDM4B_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ESR1_MOUSEEsr1physical
21445275
SMCA4_MOUSESmarca4physical
21445275
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KDM4B_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-305, AND MASSSPECTROMETRY.

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