KDM3A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KDM3A_MOUSE
• UniProt AC: Q6PCM1
• Protein Name: Lysine-specific demethylase 3A
• Gene Name: Kdm3a
• Organism: Mus musculus (Mouse).
• Sequence Length: 1323
• Subcellular Localization: Cytoplasm . Nucleus . Nuclear in round spermatids. When spermatids start to elongate, localizes to the cytoplasm where it forms distinct foci which disappear in mature spermatozoa.
• Protein Description: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation (By similarity). Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. [PubMed: 17943087 Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.]
• Protein Sequence: MVLTLGESWPVLVGKRFLSLSAAEGNEGGQDNWDLERVAEWPWLSGTIRAVSHTDVTKKDLKVCVEFDGESWRKRRWIDVYSLQRKAFLVEHNLVLAERKSPEVPEQVIQWPAIMYKSLLDKAGLGAITSVRFLGDQQSVFVSKDLLKPIQDVNSLRLSLTDNQTVSKEFQALIVKHLDESHLLQGDKNLVGSEVKIYSLDPSTQWFSATVVHGNPSSKTLQVNCEEIPALKIVDPALIHVEVVHDNFVTCGNSTRTGAVKRKSSENNGSSVSKQAKSCSEASPSMCPVQSVPTTVFKEILLGCTAATPSSKDPRQQNTPQAANSPPNIGAKLPQGCHKQNLPEELSSCLNTKPEVPRTKPDVCKEGLLSSKSSQVGAGDLKILSEPKGSCIQPKTNTDQESRLESAPQPVTGLPKECLPAKTSSKAELDIATTPELQKHLEHAASTSDDLSDKPEVKAGVTSLNSCAEKKVEPSHLGSQSQNLKETSVKVDNESCCTRSSNKTQTPPARKSVLTDPDKVRKLQQSGEAFVQDDSCVNIVAQLPKCRECRLDSLRKDKDQQKDSPVFCRFFHFRRLQFNKHGVLRVEGFLTPNKYDSEAIGLWLPLTKNVVGTDLDTAKYILANIGDHFCQMVISEKEAMSTIEPHRQVAWKRAVKGVREMCDVCDTTIFNLHWVCPRCGFGVCVDCYRMKRKNCQQGAAYKTFSWIRCVKSQIHEPENLMPTQIIPGKALYDVGDIVHSVRAKWGIKANCPCSNRQFKLFSKPALKEDLKQTSLSGEKPTLGTMVQQSSPVLEPVAVCGEAASKPASSVKPTCPTSTSPLNWLADLTSGNVNKENKEKQLTMPILKNEIKCLPPLPPLNKPSTVLHTFNSTILTPVSNNNSGFLRNLLNSSTAKTENGLKNTPKILDDIFASLVQNKTSSDSSKRPQGLTIKPSILGFDTPHYWLCDNRLLCLQDPNNKSNWNVFRECWKQGQPVMVSGVHHKLNTELWKPESFRKEFGEQEVDLVNCRTNEIITGATVGDFWDGFEDVPNRLKNDKEKEPMVLKLKDWPPGEDFRDMMPSRFDDLMANIPLPEYTRRDGKLNLASRLPNYFVRPDLGPKMYNAYGLITPEDRKYGTTNLHLDVSDAANVMVYVGIPKGQCEQEEEVLRTIQDGDSDELTIKRFIEGKEKPGALWHIYAAKDTEKIREFLKKVSEEQGQDNPADHDPIHDQSWYLDRSLRKRLYQEYGVQGWAIVQFLGDVVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFWLTQEFRYLSQTHTNHEDKLQVKNVIYHAVKDAVAMLKASESSLGKP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
257	Phosphorylation	TCGNSTRTGAVKRKS ECCCCCCCCCCEECC	29.58	-
264	Phosphorylation	TGAVKRKSSENNGSS CCCCEECCCCCCCCC	47.09	25266776
265	Phosphorylation	GAVKRKSSENNGSSV CCCEECCCCCCCCCH	47.59	25266776
308	Phosphorylation	LLGCTAATPSSKDPR HHCCCCCCCCCCCHH	22.65	28059163
319	Phosphorylation	KDPRQQNTPQAANSP CCHHHCCCCCHHCCC	16.67	28285833
325	Phosphorylation	NTPQAANSPPNIGAK CCCCHHCCCCCCCCC	36.69	25619855
374	Phosphorylation	GLLSSKSSQVGAGDL CHHCCCCCCCCCCCC	32.40	27600695
433	Phosphorylation	KAELDIATTPELQKH CHHHCCCCCHHHHHH	43.12	25266776
434	Phosphorylation	AELDIATTPELQKHL HHHCCCCCHHHHHHH	13.02	26745281
446	Phosphorylation	KHLEHAASTSDDLSD HHHHHHHCCCCCCCC	29.27	26060331
447	Phosphorylation	HLEHAASTSDDLSDK HHHHHHCCCCCCCCC	31.30	26060331
448	Phosphorylation	LEHAASTSDDLSDKP HHHHHCCCCCCCCCH	26.99	25266776
553	Phosphorylation	CRECRLDSLRKDKDQ CCCCCHHHHHCCHHH	34.37	26370283
591	Phosphorylation	LRVEGFLTPNKYDSE EEEEEEECCCCCCCC	23.66	22006019
789	Phosphorylation	LGTMVQQSSPVLEPV HHHCCCCCCCCCEEE	21.37	26643407
790	Phosphorylation	GTMVQQSSPVLEPVA HHCCCCCCCCCEEEE	18.06	26643407
816	Phosphorylation	SVKPTCPTSTSPLNW HCCCCCCCCCCCCHH	46.94	26643407
817	Phosphorylation	VKPTCPTSTSPLNWL CCCCCCCCCCCCHHH	16.42	26643407
818	Phosphorylation	KPTCPTSTSPLNWLA CCCCCCCCCCCHHHH	36.52	26643407
819	Phosphorylation	PTCPTSTSPLNWLAD CCCCCCCCCCHHHHH	27.45	26643407
895	Ubiquitination	LLNSSTAKTENGLKN HHHCCCCCCCCCCCC	57.36	22790023
895	Acetylation	LLNSSTAKTENGLKN HHHCCCCCCCCCCCC	57.36	-
903	Phosphorylation	TENGLKNTPKILDDI CCCCCCCCHHHHHHH	25.11	21454597
918	Ubiquitination	FASLVQNKTSSDSSK HHHHHCCCCCCCCCC	32.47	22790023
1118	Phosphorylation	PEDRKYGTTNLHLDV HHHHCCCCCEEEEEH	14.93	29895711
1119	Phosphorylation	EDRKYGTTNLHLDVS HHHCCCCCEEEEEHH	31.27	29895711
1126	Phosphorylation	TNLHLDVSDAANVMV CEEEEEHHHCCCEEE	22.62	29895711
1163	Acetylation	DSDELTIKRFIEGKE CCCCEEEHHHHCCCC	35.70	2388431
1169	Acetylation	IKRFIEGKEKPGALW EHHHHCCCCCCCCEE	50.18	2388439
1179	Phosphorylation	PGALWHIYAAKDTEK CCCEEEEEECCCHHH	6.39	21454597
1268	Phosphorylation	KVAEDFVSPEHVKHC HHHHCCCCHHHHHHH	25.27	26745281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KDM3A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KDM3A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KDM3A_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of KDM3A_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.