KDM1B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KDM1B_MOUSE
• UniProt AC: Q8CIG3
• Protein Name: Lysine-specific histone demethylase 1B
• Gene Name: Kdm1b
• Organism: Mus musculus (Mouse).
• Sequence Length: 826
• Subcellular Localization: Nucleus .
• Protein Description: Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4..
• Protein Sequence: MAASRGRSKKRSNLELSPDNLPLRSSGRQAKKKAVEIPDEDEDGSSEKKYRKCEKAGCTAAYPVCFASASERCAKNGYTSRWYHLSCGEHFCNECFDHYYRSHKDGYDKYSAWKRVWTSNGKTEPSPKAFMADQQLPYWVQCTKPECGKWRQLTKEIQLTPHMARTYRCGMKPNTITKPDTPDHCSFPEDLRVLEVSNHWWYPMLIQPPLLKDSVAAPLLSAYYPDCVGMSPSCTSTHRATVTAATTTTGSASPGEMEPSKAAPSSLVLGMNRYFQPFYQPNECGKALCVRPDVMELDELYEFPEYSRDPTMYLALRNLILALWYTNCKEALTPQKCIPHIIVRGLVRIRCVQEVERILYFMTRKGLINTGVLTVAAGQHLLPKHYHNKSVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVWDDKSFKGVVVGRGPQIVNGCINNPVALMCEQLGISMRKLGERCDLIQEGGRITDPTVDKRMDFHFNALLDVVSEWRKDKTLLQDVPLGEKIEEIYRAFVKESGIQFSELEGQVLQFHLSNLEYACGSSLHQVSARSWDHNEFFAQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVTTTDGMGHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVQGADFFGHVPPSASQRGLFAVFYDMDSQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEIPEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDIIAEEIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAAF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	RGRSKKRSNLELSPD CCCCCCCCCCCCCCC	55.43	25777480
17	Phosphorylation	KRSNLELSPDNLPLR CCCCCCCCCCCCCCC	22.34	26824392
26	Phosphorylation	DNLPLRSSGRQAKKK CCCCCCCCCCCCCCC	31.40	-
45	Phosphorylation	PDEDEDGSSEKKYRK CCCCCCCCCHHHHHH	47.87	25338131
241	Phosphorylation	CTSTHRATVTAATTT CCCCCEEEEEEEEEE	20.53	25619855
243	Phosphorylation	STHRATVTAATTTTG CCCEEEEEEEEEECC	13.25	25619855
246	Phosphorylation	RATVTAATTTTGSAS EEEEEEEEEECCCCC	23.39	25619855
247	Phosphorylation	ATVTAATTTTGSASP EEEEEEEEECCCCCC	20.03	25619855
248	Phosphorylation	TVTAATTTTGSASPG EEEEEEEECCCCCCC	25.46	25619855
249	Phosphorylation	VTAATTTTGSASPGE EEEEEEECCCCCCCC	27.35	25619855
251	Phosphorylation	AATTTTGSASPGEME EEEEECCCCCCCCCC	24.39	25619855
253	Phosphorylation	TTTTGSASPGEMEPS EEECCCCCCCCCCCC	34.82	25521595
260	Phosphorylation	SPGEMEPSKAAPSSL CCCCCCCCCCCCCCE	22.94	25619855
632	Phosphorylation	SAQKVLVTVPLAILQ CCCEEEEHHHHHHHH	16.55	51460277
655	Ubiquitination	PLSEKKMKAINSLGA CCCHHHHHHHHHCCC	55.80	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KDM1B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KDM1B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KDM1B_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of KDM1B_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.