| UniProt ID | KDF1_HUMAN | |
|---|---|---|
| UniProt AC | Q8NAX2 | |
| Protein Name | Keratinocyte differentiation factor 1 | |
| Gene Name | KDF1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 398 | |
| Subcellular Localization | Cytoplasm . Cell junction . Localized at cell borders in single layered keratinocytes. Localized at cell borders in the basal and spinous layers but is more diffusely localized in the granular layer. Colocalized with actin near the cell membrane, esp | |
| Protein Description | Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny (By similarity).. | |
| Protein Sequence | MPRPGHPRPASGPPRLGPWERPTELCLETYDKPPQPPPSRRTRRPDPKDPGHHGPESITFISGSAEPALESPTCCLLWRPWVWEWCRAAFCFRRCRDCLQRCGACVRGCSPCLSTEDSTEGTAEANWAKEHNGVPPSPDRAPPSRRDGQRLKSTMGSSFSYPDVKLKGIPVYPYPRATSPAPDADSCCKEPLADPPPMRHSLPSTFASSPRGSEEYYSFHESDLDLPEMGSGSMSSREIDVLIFKKLTELFSVHQIDELAKCTSDTVFLEKTSKISDLISSITQDYHLDEQDAEGRLVRGIIRISTRKSRARPQTSEGRSTRAAAPTAAAPDSGHETMVGSGLSQDELTVQISQETTADAIARKLRPYGAPGYPASHDSSFQGTDTDSSGAPLLQVYC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 11 | Phosphorylation | PGHPRPASGPPRLGP CCCCCCCCCCCCCCC | 25394399 | ||
| 30 | Phosphorylation | TELCLETYDKPPQPP CHHHHHCCCCCCCCC | 22817900 | ||
| 118 | Phosphorylation | PCLSTEDSTEGTAEA CCCCCCCCCCCCHHH | - | ||
| 119 | Phosphorylation | CLSTEDSTEGTAEAN CCCCCCCCCCCHHHH | - | ||
| 122 | Phosphorylation | TEDSTEGTAEANWAK CCCCCCCCHHHHHHH | - | ||
| 137 | Phosphorylation | EHNGVPPSPDRAPPS HHCCCCCCCCCCCCC | 25849741 | ||
| 144 | Phosphorylation | SPDRAPPSRRDGQRL CCCCCCCCCCCCHHH | 27050516 | ||
| 153 | Phosphorylation | RDGQRLKSTMGSSFS CCCHHHHHHCCCCCC | 28985074 | ||
| 154 | Phosphorylation | DGQRLKSTMGSSFSY CCHHHHHHCCCCCCC | 28176443 | ||
| 157 | Phosphorylation | RLKSTMGSSFSYPDV HHHHHCCCCCCCCCC | 29978859 | ||
| 158 | Phosphorylation | LKSTMGSSFSYPDVK HHHHCCCCCCCCCCE | 28176443 | ||
| 160 | Phosphorylation | STMGSSFSYPDVKLK HHCCCCCCCCCCEEC | 28176443 | ||
| 161 | Phosphorylation | TMGSSFSYPDVKLKG HCCCCCCCCCCEECC | 28176443 | ||
| 172 | Phosphorylation | KLKGIPVYPYPRATS EECCCCCCCCCCCCC | 28152594 | ||
| 174 | Phosphorylation | KGIPVYPYPRATSPA CCCCCCCCCCCCCCC | 28152594 | ||
| 178 | Phosphorylation | VYPYPRATSPAPDAD CCCCCCCCCCCCCHH | 23090842 | ||
| 179 | Phosphorylation | YPYPRATSPAPDADS CCCCCCCCCCCCHHH | 25849741 | ||
| 186 | Phosphorylation | SPAPDADSCCKEPLA CCCCCHHHCCCCCCC | 25849741 | ||
| 201 | Phosphorylation | DPPPMRHSLPSTFAS CCCCCCCCCCCCCCC | 25849741 | ||
| 204 | Phosphorylation | PMRHSLPSTFASSPR CCCCCCCCCCCCCCC | 23927012 | ||
| 205 | Phosphorylation | MRHSLPSTFASSPRG CCCCCCCCCCCCCCC | 23927012 | ||
| 208 | Phosphorylation | SLPSTFASSPRGSEE CCCCCCCCCCCCCCC | 25849741 | ||
| 209 | Phosphorylation | LPSTFASSPRGSEEY CCCCCCCCCCCCCCC | 25849741 | ||
| 213 | Phosphorylation | FASSPRGSEEYYSFH CCCCCCCCCCCEECC | 21406692 | ||
| 216 | Phosphorylation | SPRGSEEYYSFHESD CCCCCCCCEECCHHH | 21406692 | ||
| 217 | Phosphorylation | PRGSEEYYSFHESDL CCCCCCCEECCHHHC | 21406692 | ||
| 218 | Phosphorylation | RGSEEYYSFHESDLD CCCCCCEECCHHHCC | 26657352 | ||
| 222 | Phosphorylation | EYYSFHESDLDLPEM CCEECCHHHCCCCCC | 26657352 | ||
| 231 | Phosphorylation | LDLPEMGSGSMSSRE CCCCCCCCCCCCHHH | 27080861 | ||
| 233 | Phosphorylation | LPEMGSGSMSSREID CCCCCCCCCCHHHCE | 27080861 | ||
| 235 | Phosphorylation | EMGSGSMSSREIDVL CCCCCCCCHHHCEEE | 27080861 | ||
| 236 | Phosphorylation | MGSGSMSSREIDVLI CCCCCCCHHHCEEEH | 27080861 | ||
| 286 | Phosphorylation | ISSITQDYHLDEQDA HHHHHCCCCCCHHHC | 27642862 | ||
| 305 | Phosphorylation | VRGIIRISTRKSRAR HHHEEEEECCCCCCC | 23312004 | ||
| 306 | Phosphorylation | RGIIRISTRKSRARP HHEEEEECCCCCCCC | 23312004 | ||
| 315 | Phosphorylation | KSRARPQTSEGRSTR CCCCCCCCCCCCCCC | 28102081 | ||
| 316 | Phosphorylation | SRARPQTSEGRSTRA CCCCCCCCCCCCCCC | 28102081 | ||
| 368 | Phosphorylation | IARKLRPYGAPGYPA HHHHHCCCCCCCCCC | 27642862 | ||
| 373 | Phosphorylation | RPYGAPGYPASHDSS CCCCCCCCCCCCCCC | 27642862 | ||
| 376 | Phosphorylation | GAPGYPASHDSSFQG CCCCCCCCCCCCCCC | 23898821 | ||
| 379 | Phosphorylation | GYPASHDSSFQGTDT CCCCCCCCCCCCCCC | 23898821 | ||
| 380 | Phosphorylation | YPASHDSSFQGTDTD CCCCCCCCCCCCCCC | 28348404 | ||
| 397 | Phosphorylation | GAPLLQVYC------ CCCEEEEEC------ | 27642862 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KDF1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KDF1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KDF1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of KDF1_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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