KCY_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCY_RAT
• UniProt AC: Q4KM73
• Protein Name: UMP-CMP kinase {ECO:0000255|HAMAP-Rule:MF_03172}
• Gene Name: Cmpk1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 196
• Subcellular Localization: Nucleus . Cytoplasm . Predominantly nuclear.
• Protein Description: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity..
• Protein Sequence: MKPLVVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNPDSQYGELIEKYIKEGKIVPVEITISLLKREMDQTMAANAQKNKFLIDGFPRNQDNLQGWNKTMDGKADVSFVLFFDCNNEICIDRCLERGKSSGRSDDNRESLEKRIQTYLESTKPIIDLYEEMGKVKKIDASKSVDEVFGDVMKIFDKEG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Acetylation	QCARIVEKYGYTHLS HHHHHHHHHCCCEEC	32.84	22902405
33	Phosphorylation	KYGYTHLSAGELLRD HHCCCEECHHHHHHC	26.99	-
43	Acetylation	ELLRDERKNPDSQYG HHHHCHHHCCCCHHH	71.44	22902405
43	Ubiquitination	ELLRDERKNPDSQYG HHHHCHHHCCCCHHH	71.44	-
43	Succinylation	ELLRDERKNPDSQYG HHHHCHHHCCCCHHH	71.44	26843850
49	Phosphorylation	RKNPDSQYGELIEKY HHCCCCHHHHHHHHH	19.27	-
55	Acetylation	QYGELIEKYIKEGKI HHHHHHHHHHHCCCE	45.33	22902405
106	Succinylation	DNLQGWNKTMDGKAD CCCCCCCCCCCCCCC	38.42	-
106	Succinylation	DNLQGWNKTMDGKAD CCCCCCCCCCCCCCC	38.42	-
147	Phosphorylation	RSDDNRESLEKRIQT CCCCCHHHHHHHHHH	38.29	25575281
150	Acetylation	DNRESLEKRIQTYLE CCHHHHHHHHHHHHH	61.16	22902405
180	Phosphorylation	KKIDASKSVDEVFGD EECCCCCCHHHHHHH	32.10	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCY_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCY_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCY_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of KCY_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.