KCY_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCY_MOUSE
• UniProt AC: Q9DBP5
• Protein Name: UMP-CMP kinase {ECO:0000255|HAMAP-Rule:MF_03172}
• Gene Name: Cmpk1
• Organism: Mus musculus (Mouse).
• Sequence Length: 196
• Subcellular Localization: Nucleus . Cytoplasm . Predominantly nuclear.
• Protein Description: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity..
• Protein Sequence: MKPLVVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNPDSQYGELIEKYIKEGKIVPVEITISLLKREMDQTMAANAQKNKFLIDGFPRNQDNLQGWNKTMDGKADVSFVLFFDCNNEICIERCLERGKSSGRSDDNRESLEKRIQTYLESTKPIIDLYEEMGKVKKIDASKSVDEVFGEVVKIFDKEG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Ubiquitination	------MKPLVVFVL ------CCCEEEEEE	47.24	22790023
26	Acetylation	QCARIVEKYGYTHLS HHHHHHHHHCCCEEC	32.84	23954790
26	Ubiquitination	QCARIVEKYGYTHLS HHHHHHHHHCCCEEC	32.84	22790023
33	Phosphorylation	KYGYTHLSAGELLRD HHCCCEECHHHHHHC	26.99	22817900
43	Acetylation	ELLRDERKNPDSQYG HHHHCHHHCCCCHHH	71.44	23806337
43	Ubiquitination	ELLRDERKNPDSQYG HHHHCHHHCCCCHHH	71.44	-
43	Malonylation	ELLRDERKNPDSQYG HHHHCHHHCCCCHHH	71.44	26320211
47	Phosphorylation	DERKNPDSQYGELIE CHHHCCCCHHHHHHH	26.93	25367039
49	Phosphorylation	RKNPDSQYGELIEKY HHCCCCHHHHHHHHH	19.27	25367039
55	Malonylation	QYGELIEKYIKEGKI HHHHHHHHHHHCCCE	45.33	26320211
55	Acetylation	QYGELIEKYIKEGKI HHHHHHHHHHHCCCE	45.33	23236377
55	Ubiquitination	QYGELIEKYIKEGKI HHHHHHHHHHHCCCE	45.33	-
60	Phosphorylation	IEKYIKEGKIVPVEI HHHHHHCCCEEEEEH	21.71	24719451
61	Phosphorylation	EKYIKEGKIVPVEIT HHHHHCCCEEEEEHH	41.44	24719451
88	Ubiquitination	AANAQKNKFLIDGFP HHHHHCCCEEECCCC	48.89	22790023
106	Succinylation	DNLQGWNKTMDGKAD CCCCCCCCCCCCCCC	38.42	-
106	Acetylation	DNLQGWNKTMDGKAD CCCCCCCCCCCCCCC	38.42	23806337
106	Succinylation	DNLQGWNKTMDGKAD CCCCCCCCCCCCCCC	38.42	23806337
106	Malonylation	DNLQGWNKTMDGKAD CCCCCCCCCCCCCCC	38.42	26320211
106	Ubiquitination	DNLQGWNKTMDGKAD CCCCCCCCCCCCCCC	38.42	-
147	Phosphorylation	RSDDNRESLEKRIQT CCCCCHHHHHHHHHH	38.29	25521595
150	Acetylation	DNRESLEKRIQTYLE CCHHHHHHHHHHHHH	61.16	6567291
166	Phosphorylation	TKPIIDLYEEMGKVK CCCHHHHHHHHCCCE	13.19	25367039
173	Acetylation	YEEMGKVKKIDASKS HHHHCCCEECCCCCC	47.71	7618115
178	Phosphorylation	KVKKIDASKSVDEVF CCEECCCCCCHHHHH	23.01	19060867
180	Phosphorylation	KKIDASKSVDEVFGE EECCCCCCHHHHHHH	32.10	26824392
190	Acetylation	EVFGEVVKIFDKEG- HHHHHHEEECCCCC-	42.71	7618125
190	Ubiquitination	EVFGEVVKIFDKEG- HHHHHHEEECCCCC-	42.71	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCY_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCY_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCY_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of KCY_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.