KCY3_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCY3_ARATH
• UniProt AC: O04905
• Protein Name: UMP-CMP kinase 3 {ECO:0000255|HAMAP-Rule:MF_03172}
• Gene Name: UMK3
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 202
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Does not act on dCMP and dUMP..
• Protein Sequence: MGSVDAANGSGKKPTVIFVLGGPGSGKGTQCAYIVEHYGYTHLSAGDLLRAEIKSGSENGTMIQNMIKEGKIVPSEVTIKLLQKAIQENGNDKFLIDGFPRNEENRAAFEKVTEIEPKFVLFFDCPEEEMEKRLLGRNQGREDDNIETIRKRFKVFLESSLPVIHYYEAKGKVRKINAAKPIEAVFEEVKAIFSPEAEKVEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MGSVDAANGS -----CCCCCCCCCC		25561503
75	Phosphorylation	KEGKIVPSEVTIKLL HCCCCCCCHHHHHHH		22074104
78	Phosphorylation	KIVPSEVTIKLLQKA CCCCCHHHHHHHHHH		22074104
113	Phosphorylation	RAAFEKVTEIEPKFV HHHHHHHHCCCCCEE		23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCY3_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCY3_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCY3_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of KCY3_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.