KCTD3_MOUSE - dbPTM
KCTD3_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KCTD3_MOUSE
UniProt AC Q8BFX3
Protein Name BTB/POZ domain-containing protein KCTD3
Gene Name Kctd3
Organism Mus musculus (Mouse).
Sequence Length 815
Subcellular Localization Cell membrane .
Protein Description Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics..
Protein Sequence MAGGHCGSFAASAASSGEIVQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGRISTLRDETGAIFIDRDPAAFAPILNFLRTKELDLRGVSINVLRHEAEFYGITPLVRRLLLCEELERSSCGSVLFHGYLPPPGIPSRKVTNTARSSVDARNGLNSMEGEARGNGTQPVLAGNGEDTIRLGVPVDPRKVLIVAGHHNWIVAAYAHFAVCYRIKESSGWQQVFTSPYLDWTIERVALNAKVVGGPHGDKDKMVAVASESSIILWSVQDGGSGSEIGVFSLGVPVDALFFIGNQLVATSHTGKVGVWNAVTQHWQVQDVVPITSYDTAGSFLLLGCNNGSIYYIDMQKFPLRMKDNDLLVTELYHDPSNDAVTALSVYLTPKTSVSGNWIEIAYGTSSGAVRVIVQHPETVGSGPQLFQTFTVHRSPVTKIMLSEKHLVSVCADNNHVRTWTVTRFRGMISTQPGSTPLASFKILSLEETESHGSYSSGNDIGPFGERDDQQVFIQKVVPITNKLFVRLSSTGKRICEIQAVDCTTISSFTVRECEGSSRMGSRPRRYLFTGHTNGSIQMWDLTTAMDMVNKTEDKDAGGPTEEELLKLLDQCDLSTSRCATPNISPATSVLQHSRLRESSSSLQLQHHETIHEAATYGATRPYRESPLLARARRTESFHSYRDFQTLNLNRSIERPVPENGHMGPAQTEVKGAAGECAMSERRSPGTEVRCGRESDGGLEVHRTAEGLSEPKKRSAEDENEHKVEFRKKGFEAGGFLGRKKVPYLASSPSTSDGGTDSPGTASPSPTKTTPSPRHKKSDSSGQEYSL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
35PhosphorylationRFSTSRQTLMWIPDS
EEECCCCEEEECCHH		19.92-
54PhosphorylationLLSGRISTLRDETGA
HHHCCCCCCCCCCCC		24.36-
142PhosphorylationPSRKVTNTARSSVDA
CCCCCCCCCCCCHHH		17.6825338131
146PhosphorylationVTNTARSSVDARNGL
CCCCCCCCHHHCCCH		20.6125338131
423PhosphorylationQTFTVHRSPVTKIML
EEEEEECCCCCEEEE		14.62-
426PhosphorylationTVHRSPVTKIMLSEK
EEECCCCCEEEECCC		20.45-
427UbiquitinationVHRSPVTKIMLSEKH
EECCCCCEEEECCCE		26.7622790023
431PhosphorylationPVTKIMLSEKHLVSV
CCCEEEECCCEEEEE		27.50-
511UbiquitinationKVVPITNKLFVRLSS
EEEECCCCEEEEECC		34.3522790023
532PhosphorylationEIQAVDCTTISSFTV
EEEEEECCEECEEEE		23.7725777480
533PhosphorylationIQAVDCTTISSFTVR
EEEEECCEECEEEEE		25.7825777480
535PhosphorylationAVDCTTISSFTVREC
EEECCEECEEEEEEC		19.8025777480
536PhosphorylationVDCTTISSFTVRECE
EECCEECEEEEEECC		22.5325777480
538PhosphorylationCTTISSFTVRECEGS
CCEECEEEEEECCCC		22.1725777480
589PhosphorylationDKDAGGPTEEELLKL
CCCCCCCCHHHHHHH		60.3429119230
603PhosphorylationLLDQCDLSTSRCATP
HHHHCCCCCCCCCCC		15.8726643407
604PhosphorylationLDQCDLSTSRCATPN
HHHCCCCCCCCCCCC		27.7326643407
605PhosphorylationDQCDLSTSRCATPNI
HHCCCCCCCCCCCCC		23.2226643407
609PhosphorylationLSTSRCATPNISPAT
CCCCCCCCCCCCCCH		22.0919060867
613PhosphorylationRCATPNISPATSVLQ
CCCCCCCCCCHHHHH		18.3419060867
616PhosphorylationTPNISPATSVLQHSR
CCCCCCCHHHHHHHH		23.8128066266
617PhosphorylationPNISPATSVLQHSRL
CCCCCCHHHHHHHHH		23.9628066266
622PhosphorylationATSVLQHSRLRESSS
CHHHHHHHHHCCCCC		21.7628066266
654PhosphorylationATRPYRESPLLARAR
CCCCCCCCCHHHHHH		16.3228066266
665PhosphorylationARARRTESFHSYRDF
HHHHCCCCCCCCCCC		27.8724899341
680PhosphorylationQTLNLNRSIERPVPE
CCCCCCCCCCCCCCC		27.9423684622
708PhosphorylationAAGECAMSERRSPGT
CHHHHHHCCCCCCCC		14.9326643407
712PhosphorylationCAMSERRSPGTEVRC
HHHCCCCCCCCEEEC		33.6224899341
715PhosphorylationSERRSPGTEVRCGRE
CCCCCCCCEEECCCC		34.3926643407
772PhosphorylationLGRKKVPYLASSPST
CCCCCCCEEECCCCC		20.2129895711
775PhosphorylationKKVPYLASSPSTSDG
CCCCEEECCCCCCCC		39.9429895711
776PhosphorylationKVPYLASSPSTSDGG
CCCEEECCCCCCCCC		19.7729895711
780PhosphorylationLASSPSTSDGGTDSP
EECCCCCCCCCCCCC		38.3026745281
784PhosphorylationPSTSDGGTDSPGTAS
CCCCCCCCCCCCCCC		38.5426745281
786PhosphorylationTSDGGTDSPGTASPS
CCCCCCCCCCCCCCC		25.6826060331
789PhosphorylationGGTDSPGTASPSPTK
CCCCCCCCCCCCCCC		27.6126643407
791PhosphorylationTDSPGTASPSPTKTT
CCCCCCCCCCCCCCC		26.2526745281
793PhosphorylationSPGTASPSPTKTTPS
CCCCCCCCCCCCCCC		42.5826745281
795PhosphorylationGTASPSPTKTTPSPR
CCCCCCCCCCCCCCC		45.4126745281
806PhosphorylationPSPRHKKSDSSGQEY
CCCCCCCCCCCCCCC		47.7521743459
808PhosphorylationPRHKKSDSSGQEYSL
CCCCCCCCCCCCCCC		43.3824899341
809PhosphorylationRHKKSDSSGQEYSL-
CCCCCCCCCCCCCC-		49.8721743459
814PhosphorylationDSSGQEYSL------
CCCCCCCCC------		27.1822006019
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KCTD3_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KCTD3_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KCTD3_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HCN3_MOUSEHcn3physical
23382386
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KCTD3_MOUSE

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Related Literatures of Post-Translational Modification

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