KCRM_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCRM_RAT
• UniProt AC: P00564
• Protein Name: Creatine kinase M-type
• Gene Name: Ckm
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 381
• Subcellular Localization: Cytoplasm.
• Protein Description: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa..
• Protein Sequence: MPFGNTHNKFKLNYKPQEEYPDLSKHNNHMAKVLTPDLYNKLRDKETPSGFTLDDVIQTGVDNPGHPFIMTVGCVAGDEESYTVFKDLFDPIIQDRHGGYKPTDKHKTDLNHENLKGGDDLDPNYVLSSRVRTGRSIKGYTLPPHCSRGERRAVEKLSVEALNSLTGEFKGKYYPLKSMTEQEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKSFLVWVNEEDHLRVISMEKGGNMKEVFRRFCVGLQKIEEIFKKAGHPFMWNEHLGYVLTCPSNLGTGLRGGVHVKLANLSKHPKFEEILTRLRLQKRGTGGVDTAAVGAVFDISNADRLGSSEVEQVQLVVDGVKLMVEMEKKLEKGQSIDDMIPAQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Acetylation	GNTHNKFKLNYKPQE CCCCCCCCCCCCCHH	37.12	22902405
32	Acetylation	KHNNHMAKVLTPDLY HCCCHHHHHCCHHHH	30.15	22902405
35	Phosphorylation	NHMAKVLTPDLYNKL CHHHHHCCHHHHHHH	20.11	22673903
39	Phosphorylation	KVLTPDLYNKLRDKE HHCCHHHHHHHCCCC	20.03	22673903
41	Acetylation	LTPDLYNKLRDKETP CCHHHHHHHCCCCCC	31.20	22902405
107	Acetylation	YKPTDKHKTDLNHEN CCCCCCCCCCCCCCC	49.85	22902405
116	Acetylation	DLNHENLKGGDDLDP CCCCCCCCCCCCCCH	72.87	22902405
125	Phosphorylation	GDDLDPNYVLSSRVR CCCCCHHHEEECCCC	14.25	23991683
128	Phosphorylation	LDPNYVLSSRVRTGR CCHHHEEECCCCCCC	13.17	23991683
129	Phosphorylation	DPNYVLSSRVRTGRS CHHHEEECCCCCCCC	30.54	23991683
138	Acetylation	VRTGRSIKGYTLPPH CCCCCCCCCCCCCCC	47.30	22902405
140	Phosphorylation	TGRSIKGYTLPPHCS CCCCCCCCCCCCCCC	10.49	22609512
141	Phosphorylation	GRSIKGYTLPPHCSR CCCCCCCCCCCCCCH	41.27	-
156	Acetylation	GERRAVEKLSVEALN HHHHHHHHHCHHHHH	39.19	22902405
164	Phosphorylation	LSVEALNSLTGEFKG HCHHHHHHCCCCCCC	28.32	22673903
166	Phosphorylation	VEALNSLTGEFKGKY HHHHHHCCCCCCCEE	34.19	22673903
170	Acetylation	NSLTGEFKGKYYPLK HHCCCCCCCEEECCC	50.63	26302492
172	Acetylation	LTGEFKGKYYPLKSM CCCCCCCEEECCCCC	42.05	22902405
174	Phosphorylation	GEFKGKYYPLKSMTE CCCCCEEECCCCCCH	12.94	22609512
177	Acetylation	KGKYYPLKSMTEQEQ CCEEECCCCCCHHHH	33.41	22902405
178	Phosphorylation	GKYYPLKSMTEQEQQ CEEECCCCCCHHHHH	38.32	22673903
180	Phosphorylation	YYPLKSMTEQEQQQL EECCCCCCHHHHHHH	41.42	22673903
196	Acetylation	DDHFLFDKPVSPLLL CCCCCCCCCCHHHHH	39.73	22902405
199	Phosphorylation	FLFDKPVSPLLLASG CCCCCCCHHHHHHHC	20.54	22673903
205	Phosphorylation	VSPLLLASGMARDWP CHHHHHHHCCCCCCC	29.13	22673903
223	Acetylation	GIWHNDNKSFLVWVN CCEECCCCCEEEEEC	45.51	22902405
242	Acetylation	LRVISMEKGGNMKEV EEEEEEECCCCHHHH	64.57	22902405
247	Acetylation	MEKGGNMKEVFRRFC EECCCCHHHHHHHHH	55.51	22902405
259	Acetylation	RFCVGLQKIEEIFKK HHHHHHHHHHHHHHH	58.07	26302492
265	Acetylation	QKIEEIFKKAGHPFM HHHHHHHHHCCCCCC	47.58	22902405
266	Acetylation	KIEEIFKKAGHPFMW HHHHHHHHCCCCCCC	49.18	26302492
279	Phosphorylation	MWNEHLGYVLTCPSN CCCCCCCEEEECCCC	9.92	-
298	Acetylation	LRGGVHVKLANLSKH CCCCEEEEECCCCCC	27.31	22902405
303	Phosphorylation	HVKLANLSKHPKFEE EEEECCCCCCCCHHH	28.82	22673903
304	Acetylation	VKLANLSKHPKFEEI EEECCCCCCCCHHHH	68.07	22902405
307	Acetylation	ANLSKHPKFEEILTR CCCCCCCCHHHHHHH	66.19	22902405
313	Phosphorylation	PKFEEILTRLRLQKR CCHHHHHHHHHHHHC	33.06	22673903
322	Phosphorylation	LRLQKRGTGGVDTAA HHHHHCCCCCCCHHH	34.49	22673903
327	Phosphorylation	RGTGGVDTAAVGAVF CCCCCCCHHHHHHEE	17.70	22673903
344	Phosphorylation	SNADRLGSSEVEQVQ CCCCCCCCCCCEEEE	28.11	22673903
345	Phosphorylation	NADRLGSSEVEQVQL CCCCCCCCCCEEEEE	43.81	22673903
365	Acetylation	KLMVEMEKKLEKGQS HHHHHHHHHHHCCCC	62.44	22902405
366	Acetylation	LMVEMEKKLEKGQSI HHHHHHHHHHCCCCH	48.88	26302492
369	Acetylation	EMEKKLEKGQSIDDM HHHHHHHCCCCHHHC	73.09	22902405
372	Phosphorylation	KKLEKGQSIDDMIPA HHHHCCCCHHHCCCC	36.33	28826663

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
128	S	Phosphorylation	Kinase	PRKCB	P05771-2	GPS
128	S	Phosphorylation	Kinase	PRKCD	P09215	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCRM_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCRM_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of KCRM_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.