KCRB_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCRB_RAT
• UniProt AC: P07335
• Protein Name: Creatine kinase B-type
• Gene Name: Ckb
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 381
• Subcellular Localization: Cytoplasm.
• Protein Description: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa..
• Protein Sequence: MPFSNSHNTQKLRFPAEDEFPDLSSHNNHMAKVLTPELYAELRAKCTPSGFTLDDAIQTGVDNPGHPYIMTVGAVAGDEESYDVFKDLFDPIIEDRHGGYQPSDEHKTDLNPDNLQGGDDLDPNYVLSSRVRTGRSIRGFCLPPHCSRGERRAIEKLAVEALSSLDGDLSGRYYALKSMTEAEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKTFLVWINEEDHLRVISMQKGGNMKEVFTRFCTGLTQIETLFKSKNYEFMWNPHLGYILTCPSNLGTGLRAGVHIKLPHLGKHEKFSEVLKRLRLQKRGTGGVDTAAVGGVFDVSNADRLGFSEVELVQMVVDGVKLLIEMEQRLEQGQPIDDLMPAQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MPFSNSHNTQK ----CCCCCCCCCCC	31.39	27097102
6	Phosphorylation	--MPFSNSHNTQKLR --CCCCCCCCCCCCC	19.54	27097102
9	Phosphorylation	PFSNSHNTQKLRFPA CCCCCCCCCCCCCCC	22.96	27097102
11	Acetylation	SNSHNTQKLRFPAED CCCCCCCCCCCCCCC	39.32	22902405
32	Acetylation	SHNNHMAKVLTPELY CCCCCHHHHCCHHHH	30.15	22902405
35	Phosphorylation	NHMAKVLTPELYAEL CCHHHHCCHHHHHHH	20.08	27097102
39	Phosphorylation	KVLTPELYAELRAKC HHCCHHHHHHHHHHC	9.07	25403869
100	Phosphorylation	IEDRHGGYQPSDEHK HCCCCCCCCCCHHCC	23.11	27097102
103	Phosphorylation	RHGGYQPSDEHKTDL CCCCCCCCHHCCCCC	39.85	27097102
108	Phosphorylation	QPSDEHKTDLNPDNL CCCHHCCCCCCCCCC	47.85	27097102
125	Phosphorylation	GDDLDPNYVLSSRVR CCCCCHHCEEECCCC	14.25	27097102
128	Phosphorylation	LDPNYVLSSRVRTGR CCHHCEEECCCCCCC	13.17	27097102
129	Phosphorylation	DPNYVLSSRVRTGRS CHHCEEECCCCCCCC	30.54	27097102
133	Phosphorylation	VLSSRVRTGRSIRGF EEECCCCCCCCCCCE	33.81	26022182
136	Phosphorylation	SRVRTGRSIRGFCLP CCCCCCCCCCCEECC	20.27	26022182
156	Ubiquitination	GERRAIEKLAVEALS HHHHHHHHHHHHHHH	35.32	-
156	Acetylation	GERRAIEKLAVEALS HHHHHHHHHHHHHHH	35.32	22902405
163	Phosphorylation	KLAVEALSSLDGDLS HHHHHHHHCCCCCCH	35.58	27097102
164	Phosphorylation	LAVEALSSLDGDLSG HHHHHHHCCCCCCHH	31.18	27097102
170	Phosphorylation	SSLDGDLSGRYYALK HCCCCCCHHHHHHHH	26.43	27097102
178	Phosphorylation	GRYYALKSMTEAEQQ HHHHHHHCCCHHHHH	31.61	27097102
180	Phosphorylation	YYALKSMTEAEQQQL HHHHHCCCHHHHHHH	38.85	27097102
196	Acetylation	DDHFLFDKPVSPLLL CCCCCCCCCCHHHHH	39.73	72613027
199	Phosphorylation	FLFDKPVSPLLLASG CCCCCCCHHHHHHHC	20.54	27097102
205	Phosphorylation	VSPLLLASGMARDWP CHHHHHHHCCCCCCC	29.13	27097102
242	Acetylation	LRVISMQKGGNMKEV EEEEEEEECCCHHHH	61.21	25786129
242	Ubiquitination	LRVISMQKGGNMKEV EEEEEEEECCCHHHH	61.21	-
247	Acetylation	MQKGGNMKEVFTRFC EEECCCHHHHHHHHH	55.51	22902405
247	Ubiquitination	MQKGGNMKEVFTRFC EEECCCHHHHHHHHH	55.51	-
254	S-nitrosocysteine	KEVFTRFCTGLTQIE HHHHHHHHHCHHHHH	2.38	-
254	S-nitrosylation	KEVFTRFCTGLTQIE HHHHHHHHHCHHHHH	2.38	17629318
258	Phosphorylation	TRFCTGLTQIETLFK HHHHHCHHHHHHHHH	28.92	-
265	Acetylation	TQIETLFKSKNYEFM HHHHHHHHCCCCEEC	64.73	22902405
265	Ubiquitination	TQIETLFKSKNYEFM HHHHHHHHCCCCEEC	64.73	-
269	Phosphorylation	TLFKSKNYEFMWNPH HHHHCCCCEECCCCC	17.80	-
269	Nitrated tyrosine	TLFKSKNYEFMWNPH HHHHCCCCEECCCCC	17.80	-
269	Nitration	TLFKSKNYEFMWNPH HHHHCCCCEECCCCC	17.80	-
279	Phosphorylation	MWNPHLGYILTCPSN CCCCCCEEEEECCCC	10.10	-
282	Phosphorylation	PHLGYILTCPSNLGT CCCEEEEECCCCCCC	16.89	23991683
283	S-nitrosocysteine	HLGYILTCPSNLGTG CCEEEEECCCCCCCC	2.89	-
283	S-nitrosylation	HLGYILTCPSNLGTG CCEEEEECCCCCCCC	2.89	16418269
285	Phosphorylation	GYILTCPSNLGTGLR EEEEECCCCCCCCCC	47.00	23991683
289	Phosphorylation	TCPSNLGTGLRAGVH ECCCCCCCCCCCEEE	35.89	23991683
298	Acetylation	LRAGVHIKLPHLGKH CCCEEEEECCCCCCC	40.88	22902405
298	Ubiquitination	LRAGVHIKLPHLGKH CCCEEEEECCCCCCC	40.88	-
304	Acetylation	IKLPHLGKHEKFSEV EECCCCCCCHHHHHH	55.75	22902405
304	Ubiquitination	IKLPHLGKHEKFSEV EECCCCCCCHHHHHH	55.75	-
307	Acetylation	PHLGKHEKFSEVLKR CCCCCCHHHHHHHHH	54.64	22902405
309	Phosphorylation	LGKHEKFSEVLKRLR CCCCHHHHHHHHHHH	37.55	27097102
313	Acetylation	EKFSEVLKRLRLQKR HHHHHHHHHHHHHHC	55.34	22902405
313	Ubiquitination	EKFSEVLKRLRLQKR HHHHHHHHHHHHHHC	55.34	-
322	Phosphorylation	LRLQKRGTGGVDTAA HHHHHCCCCCCCCCC	34.49	27097102
327	Phosphorylation	RGTGGVDTAAVGGVF CCCCCCCCCCCCCEE	17.70	27097102
337	Phosphorylation	VGGVFDVSNADRLGF CCCEEECCCCCCCCC	28.30	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
178	S	Phosphorylation	Kinase	PRKACA	P00517	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCRB_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCRB_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of KCRB_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.