| UniProt ID | KCNQ3_HUMAN | |
|---|---|---|
| UniProt AC | O43525 | |
| Protein Name | Potassium voltage-gated channel subfamily KQT member 3 {ECO:0000305} | |
| Gene Name | KCNQ3 {ECO:0000312|HGNC:HGNC:6297} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 872 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . |
|
| Protein Description | Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability.. | |
| Protein Sequence | MGLKARRAAGAAGGGGDGGGGGGGAANPAGGDAAAAGDEERKVGLAPGDVEQVTLALGAGADKDGTLLLEGGGRDEGQRRTPQGIGLLAKTPLSRPVKRNNAKYRRIQTLIYDALERPRGWALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLLETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLATSLRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKDVPEVDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYATNPNRIDLVATWRFYESVVSFPFFRKEQLEAASSQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSKEPKPVGLNNKERFRTAFRMKAYAFWQSSEDAGTGDPMAEDRGYGNDFPIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTRIDMIFTPGPPSTPKHKKSQKGSAFTFPSQQSPRNEPYVARPSTSEIEDQSMMGKFVKVERQVQDMGKKLDFLVDMHMQHMERLQVQVTEYYPTKGTSSPAEAEKKEDNRYSDLKTIICNYSETGPPEPPYSFHQVTIDKVSPYGFFAHDPVNLPRGGPSSGKVQATPPSSATTYVERPTVLPILTLLDSRVSCHSQADLQGPYSDRISPRQRRSITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDYVFGPNGGSSWMREKRYLAEGETDTDTDPFTPSGSMPLSSTGDGISDSVWTPSNKPI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 81 | Phosphorylation | RDEGQRRTPQGIGLL CCCCCCCCCCCCCEE | 23.35 | - | |
| 125 | Phosphorylation | PRGWALLYHALVFLI CHHHHHHHHHHHHHH | 5.96 | 20058876 | |
| 184 | Phosphorylation | AAGCCCRYKGWRGRL HCHHCCCCCCHHHCC | 10.43 | - | |
| 246 | Phosphorylation | RMDRRGGTWKLLGSA HCCCCCCCCHHHHHH | 23.42 | 25982755 | |
| 456 | Phosphorylation | NVDAIEESPSKEPKP CHHHCCCCCCCCCCC | 22.99 | 29083192 | |
| 458 | Phosphorylation | DAIEESPSKEPKPVG HHCCCCCCCCCCCCC | 59.95 | 29083192 | |
| 481 | Phosphorylation | TAFRMKAYAFWQSSE HHHHHHHHHHHHCCC | 9.23 | - | |
| 502 | Phosphorylation | PMAEDRGYGNDFPIE CCCHHCCCCCCCCHH | 17.41 | 22817900 | |
| 573 | Phosphorylation | TRIDMIFTPGPPSTP HHCCEEECCCCCCCC | 19.19 | - | |
| 578 | Phosphorylation | IFTPGPPSTPKHKKS EECCCCCCCCCCCCC | 61.55 | 22817900 | |
| 579 | Phosphorylation | FTPGPPSTPKHKKSQ ECCCCCCCCCCCCCC | 41.97 | 22817900 | |
| 598 | Phosphorylation | FTFPSQQSPRNEPYV CCCCCCCCCCCCCCC | 20.42 | 24076635 | |
| 655 | O-linked_Glycosylation | ERLQVQVTEYYPTKG HHCEEEEEEECCCCC | 10.94 | 28657654 | |
| 663 | Phosphorylation | EYYPTKGTSSPAEAE EECCCCCCCCHHHHH | 27.82 | - | |
| 664 | Phosphorylation | YYPTKGTSSPAEAEK ECCCCCCCCHHHHHH | 42.89 | - | |
| 665 | Phosphorylation | YPTKGTSSPAEAEKK CCCCCCCCHHHHHHH | 28.15 | - | |
| 746 | Phosphorylation | TTYVERPTVLPILTL CCCCCCCCHHHHHHH | 40.68 | 17924679 | |
| 770 | Phosphorylation | QADLQGPYSDRISPR CCCCCCCCCCCCCHH | 29.99 | - | |
| 771 | Phosphorylation | ADLQGPYSDRISPRQ CCCCCCCCCCCCHHH | 24.44 | - | |
| 786 | Phosphorylation | RRSITRDSDTPLSLM HHCCCCCCCCCCEEE | 39.84 | 29507054 | |
| 794 | Phosphorylation | DTPLSLMSVNHEELE CCCCEEEECCHHHHH | 25.68 | 29507054 | |
| 810 | Phosphorylation | SPSGFSISQDRDDYV CCCCCCCCCCCCCCE | 25.49 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KCNQ3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KCNQ3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KCNQ3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| KCNQ2_HUMAN | KCNQ2 | physical | 12890507 | |
| KCNQ5_HUMAN | KCNQ5 | physical | 12890507 |
| Kegg Disease | |
|---|---|
| H00806 | Benign familial neonatal and infantile epilepsies, including: Benign familial neonatal epilepsy (BFN |
| OMIM Disease | |
| 121201 | Seizures, benign familial neonatal 2 (BFNS2) |
| Kegg Drug | |
| D04741 | Linopirdine (USAN/INN) |
| D09569 | Ezogabine (USAN); Retigabine (INN); Potiga (TN) |
| DrugBank | |
| DB00321 | Amitriptyline |
| DB00586 | Diclofenac |
| DB04953 | Ezogabine |
| DB00939 | Meclofenamic acid |
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| Phosphorylation | |
| Reference | PubMed |
| "Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-746, AND MASSSPECTROMETRY. | |
