KCNKA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCNKA_HUMAN
• UniProt AC: P57789
• Protein Name: Potassium channel subfamily K member 10
• Gene Name: KCNK10
• Organism: Homo sapiens (Human).
• Sequence Length: 538
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids..
• Protein Sequence: MFFLYTDFFLSLVAVPAAAPVCQPKSATNGQPPAPAPTPTPRLSISSRATVVARMEGTSQGGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHVCVSPQELETLIQHALDADNAGVSPIGNSSNNSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEIKAHAAEWKANVTAEFRETRRRLSVEIHDKLQRAATIRSMERRRLGLDQRAHSLDMLSPEKRSVFAALDTGRFKASSQESINNRPNNLRLKGPEQLNKHGQGASEDNIINKFGSTSRLTKRKNKDLKKTLPEDVQKIYKTFRNYSLDEEKKEEETEKMCNSDNSSTAMLTDCIQQHAELENGMIPTDTKDREPENNSLLEDRN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	PTPTPRLSISSRATV CCCCCCEEECCCCEE	23.00	24945436
58	Phosphorylation	VVARMEGTSQGGLQT EEEECCCCCCCHHHH	12.45	30177828
59	Phosphorylation	VARMEGTSQGGLQTV EEECCCCCCCHHHHH	37.37	30177828
82	Phosphorylation	IFVVVVVYLVTGGLV HHHHHHHHHHHCCHH	5.48	-
85	Phosphorylation	VVVVYLVTGGLVFRA HHHHHHHHCCHHHHH	23.96	-
144	N-linked_Glycosylation	AGVSPIGNSSNNSSH CCCCCCCCCCCCCCC	42.88	UniProtKB CARBOHYD
147	N-linked_Glycosylation	SPIGNSSNNSSHWDL CCCCCCCCCCCCCCC	52.83	UniProtKB CARBOHYD
148	N-linked_Glycosylation	PIGNSSNNSSHWDLG CCCCCCCCCCCCCCC	47.00	UniProtKB CARBOHYD
237	Ubiquitination	KIRVISTILFILAGC HHHHHHHHHHHHHHH	2.06	21890473
359	Phosphorylation	RETRRRLSVEIHDKL HHHHHHHHHHHHHHH	18.85	24173317
365	Ubiquitination	LSVEIHDKLQRAATI HHHHHHHHHHHHHHH	32.15	22817900
365 (in isoform 1)	Ubiquitination	-	32.15	21890473
365	Ubiquitination	LSVEIHDKLQRAATI HHHHHHHHHHHHHHH	32.15	21890473
370	Ubiquitination	HDKLQRAATIRSMER HHHHHHHHHHHHHHH	13.02	21890473
370 (in isoform 4)	Ubiquitination	-	13.02	21890473
370	Ubiquitination	HDKLQRAATIRSMER HHHHHHHHHHHHHHH	13.02	21890473
370	Ubiquitination	HDKLQRAATIRSMER HHHHHHHHHHHHHHH	13.02	21890473
370 (in isoform 3)	Ubiquitination	-	13.02	21890473
388	Phosphorylation	GLDQRAHSLDMLSPE CCCHHHHHHHHCCHH	25.69	28450419
398	Phosphorylation	MLSPEKRSVFAALDT HCCHHHHHHHHHHHC	32.43	29759185
405	Phosphorylation	SVFAALDTGRFKASS HHHHHHHCCCCCCCC	30.98	29759185
411	Phosphorylation	DTGRFKASSQESINN HCCCCCCCCHHHHHC	32.90	29759185
412	Phosphorylation	TGRFKASSQESINNR CCCCCCCCHHHHHCC	42.71	29759185
415	Phosphorylation	FKASSQESINNRPNN CCCCCHHHHHCCCCC	23.99	28450419
439	Phosphorylation	NKHGQGASEDNIINK HHCCCCCCCCCHHHH	52.92	28450419
464	Phosphorylation	KNKDLKKTLPEDVQK CCCHHHHHCHHHHHH	46.05	26074081
473	Phosphorylation	PEDVQKIYKTFRNYS HHHHHHHHHHHHHCC	15.83	26074081
479	Phosphorylation	IYKTFRNYSLDEEKK HHHHHHHCCCCHHHH	13.32	25884760
532	Phosphorylation	DREPENNSLLEDRN- CCCCCCCCCCCCCC-	46.01	28450419

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCNKA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCNKA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCNKA_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of KCNKA_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.