dbPTM

KCNK4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KCNK4_HUMAN
UniProt AC	Q9NYG8
Protein Name	Potassium channel subfamily K member 4
Gene Name	KCNK4
Organism	Homo sapiens (Human).
Sequence Length	393
Subcellular Localization	Cell membrane Multi-pass membrane protein .
Protein Description	Voltage-insensitive potassium channel. [PubMed: 22282805 Channel opening is triggered by mechanical forces that deform the membrane]
Protein Sequence	MRSTTLLALLALVLLYLVSGALVFRALEQPHEQQAQRELGEVREKFLRAHPCVSDQELGLLIKEVADALGGGADPETNSTSNSSHSAWDLGSAFFFSGTIITTIGYGNVALRTDAGRLFCIFYALVGIPLFGILLAGVGDRLGSSLRHGIGHIEAIFLKWHVPPELVRVLSAMLFLLIGCLLFVLTPTFVFCYMEDWSKLEAIYFVIVTLTTVGFGDYVAGADPRQDSPAYQPLVWFWILLGLAYFASVLTTIGNWLRVVSRRTRAEMGGLTAQAASWTGTVTARVTQRAGPAAPPPEKEQPLLPPPPCPAQPLGRPRSPSPPEKAQPPSPPTASALDYPSENLAFIDESSDTQSERGCPLPRAPRGRRRPNPPRKPVRPRGPGRPRDKGVPV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
78	N-linked_Glycosylation	GGADPETNSTSNSSH CCCCCCCCCCCCCCC	41.45	UniProtKB CARBOHYD
82	N-linked_Glycosylation	PETNSTSNSSHSAWD CCCCCCCCCCCCHHH	47.85	UniProtKB CARBOHYD
145	Phosphorylation	VGDRLGSSLRHGIGH HHHHHHHHHHHCCCE	27.85	24719451
211	Phosphorylation	YFVIVTLTTVGFGDY EEEEEECCCCCCCHH	15.29	24719451
218	Phosphorylation	TTVGFGDYVAGADPR CCCCCCHHHCCCCCC	7.80	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KCNK4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KCNK4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KCNK4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
RL14_HUMAN	RPL14	physical	21988832

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KCNK4_HUMAN

Related Literatures of Post-Translational Modification