KCNH2_RAT - dbPTM
KCNH2_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KCNH2_RAT
UniProt AC O08962
Protein Name Potassium voltage-gated channel subfamily H member 2
Gene Name Kcnh2
Organism Rattus norvegicus (Rat).
Sequence Length 1163
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity)..
Protein Sequence MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNFEVVMEKDMVGSPAHDTNHRGPSTSWLASGRAKTFRLKLPALLALTARESPMRTGSTGSPGAPGAVVVDVDLTPAAPSSESLALDEVSAMDNHVAGLGPAEERRALVGPASASPVASIPGPHPSPRAQSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGALPLPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEDGSQAPDCGYACQPLAVVDLLVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSHIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPSSAELESGFNRQRKRKLSFRRRTDKDTEQPGEVSALGQGPARVGPGPSCRGQPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGDSPGGEPLTEDGEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPAPSLLNIPLSSPGRRSRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVGPVPTLTLDSLSQVSQFVAFEELPAGAPELPQDGPTRRLSLPGQLGALTSQPLHRHGSDPGS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
157PhosphorylationPSTSWLASGRAKTFR
CCHHHHHCCCCCCHH		27.0028432305
239PhosphorylationRALVGPASASPVASI
HHCCCCCCCCCCCCC		32.20-
241PhosphorylationLVGPASASPVASIPG
CCCCCCCCCCCCCCC		19.88-
245PhosphorylationASASPVASIPGPHPS
CCCCCCCCCCCCCCC		29.56-
285PhosphorylationCASVRRASSADDIEA
HHHHHHCCCHHHHHH		25.0122108457
286PhosphorylationASVRRASSADDIEAM
HHHHHCCCHHHHHHH		34.4325403869
306PhosphorylationPLPPRHASTGAMHPL
CCCCCCCCCCCCCCC		22.6528432305
307PhosphorylationLPPRHASTGAMHPLR
CCCCCCCCCCCCCCC		29.7328432305
320PhosphorylationLRSGLLNSTSDSDLV
CCCCCCCCCCCHHHC		29.2927097102
321PhosphorylationRSGLLNSTSDSDLVR
CCCCCCCCCCHHHCH		35.1628432305
322PhosphorylationSGLLNSTSDSDLVRY
CCCCCCCCCHHHCHH		34.6327097102
324PhosphorylationLLNSTSDSDLVRYRT
CCCCCCCHHHCHHEE		32.3928432305
353PhosphorylationKGDPFLASPTSDREI
CCCCCCCCCCCCCCC		30.7525403869
355PhosphorylationDPFLASPTSDREIIA
CCCCCCCCCCCCCHH		40.5428432305
356PhosphorylationPFLASPTSDREIIAP
CCCCCCCCCCCCHHH		37.7528432305
600N-linked_GlycosylationDQIGKPYNSSGLGGP
HHCCCCCCCCCCCCC		37.92-
613PhosphorylationGPSIKDKYVTALYFT
CCCHHHCCCCEEEEE		17.1116641100
615PhosphorylationSIKDKYVTALYFTFS
CHHHCCCCEEEEEHH		14.0916641100
620PhosphorylationYVTALYFTFSSLTSV
CCCEEEEEHHCCCCC		14.7316641100
622PhosphorylationTALYFTFSSLTSVGF
CEEEEEHHCCCCCCC		22.7516641100
623PhosphorylationALYFTFSSLTSVGFG
EEEEEHHCCCCCCCC		31.3216641100
873PhosphorylationDTNMIPGSPSSAELE
CCCCCCCCCCHHHHH		19.0928432305
875PhosphorylationNMIPGSPSSAELESG
CCCCCCCCHHHHHHC		43.8328432305
876PhosphorylationMIPGSPSSAELESGF
CCCCCCCHHHHHHCC		29.1928432305
892PhosphorylationRQRKRKLSFRRRTDK
HHHHHHHCCCCCCCC		21.53-
1018MethylationRQYQELPRCPAPAPS
CCCCCCCCCCCCCCH		52.23-
1141PhosphorylationDGPTRRLSLPGQLGA
CCCCCCCCCCCCHHH		30.6128432305
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KCNH2_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KCNH2_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KCNH2_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of KCNH2_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KCNH2_RAT

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Related Literatures of Post-Translational Modification

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