KCND3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCND3_RAT
• UniProt AC: Q62897
• Protein Name: Potassium voltage-gated channel subfamily D member 3
• Gene Name: Kcnd3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 655
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Cell membrane, sarcolemma ; Multi-pass membrane protein . Cell projection, dendrite . Interaction with palmitoylated KCNIP2 and KCNIP3 enhances cell surface expression.
• Protein Description: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits..
• Protein Sequence: MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNESENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHMGKTTSLIESQHHHLLHCLEKTTGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHSGLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDGLRPNCKTSQITTAIISIPTPPALTPEGESRPPPASPGPNTNIPSITSNVVKVSVL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
153	Phosphorylation	RLMDDNESENNQESM HHCCCCCCCCCCCCC	52.45	27097102
459	Phosphorylation	EALELTGTPEEEHMG HHHHHHCCCHHHHCC	23.45	30240740
533	Phosphorylation	QNYPSTRSPSLSSHS HHCCCCCCCCCCCCC	20.94	27097102
535	Phosphorylation	YPSTRSPSLSSHSGL CCCCCCCCCCCCCCC	41.97	27097102
537	Phosphorylation	STRSPSLSSHSGLTT CCCCCCCCCCCCCCC	30.27	27097102
538	Phosphorylation	TRSPSLSSHSGLTTT CCCCCCCCCCCCCCH	27.28	27097102
540	Phosphorylation	SPSLSSHSGLTTTCC CCCCCCCCCCCCHHC	37.13	27097102
569	Phosphorylation	LPATRLRSMQELSTI CCHHHHHHHHHHEEE	29.43	15456698
585	Phosphorylation	IQGSEQPSLTTSRSS ECCCCCCCCCCCCHH	37.73	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
535	S	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
569	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
569	S	Phosphorylation	Kinase	CAMK2D	P15791	Uniprot
569	S	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
569	S	Phosphorylation	Regulated through phosphorylation at Ser-569 by CaMK2D.	15456698

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCND3_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of KCND3_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Regulation of Kv4.3 currents by Ca2+/calmodulin-dependent proteinkinase II.";
Sergeant G.P., Ohya S., Reihill J.A., Perrino B.A., Amberg G.C.,Imaizumi Y., Horowitz B., Sanders K.M., Koh S.D.;
Am. J. Physiol. 288:C304-C313(2005).
Cited for: PHOSPHORYLATION AT SER-569 BY CAMK2D.
PubMed: 15456698