| UniProt ID | KCND1_MOUSE | |
|---|---|---|
| UniProt AC | Q03719 | |
| Protein Name | Potassium voltage-gated channel subfamily D member 1 | |
| Gene Name | Kcnd1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 651 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein. Cell projection, dendrite. |
|
| Protein Description | Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in the heart and I(Sa) current in neurons. Channel properties are modulated by subunit assembly.. | |
| Protein Sequence | MAAGVATWLPFARAAAVGWLPLAQQPLPPAPEVKASRGDEVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEFFYDAESGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRKKENAERLAEDEEAEQAGEGPALPAGSSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIPCRGTPRWPSKEQSCGDRFPTAFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLFVPKNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTSKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQQKVRLARIRLAKSGTTNAFLQYKQNGGLEDSGSGDGQMLCVRSRSAFEQQHHHLLHCLEKTTCHEFTDELTFSEALGAVSLGGRTSRSTSVSSQPMGPGSLFSSCCSRRVNRRAIRLANSTASVSRGSMQELDTLAGLRRSPAPQTRSSLNAKPHDSLDLNCDSRDFVAAIISIPTPPANTPDESQPSSPSGGGGSGGTPNTTLRNSSLGTPCLLPETVKISSL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 317 | Phosphorylation | QGLRILGYTLKSCAS CCCHHHCHHHHHHHH | 12.88 | 22817900 | |
| 318 | Phosphorylation | GLRILGYTLKSCASE CCHHHCHHHHHHHHH | 26.38 | 22817900 | |
| 355 | N-linked_Glycosylation | EKGTSKTNFTSIPAA HHCCCCCCCCCCCHH | 41.77 | - | |
| 458 | Phosphorylation | QNGGLEDSGSGDGQM HHCCCCCCCCCCCCE | 26.03 | 22817900 | |
| 460 | Phosphorylation | GGLEDSGSGDGQMLC CCCCCCCCCCCCEEE | 37.35 | 25521595 | |
| 547 | Phosphorylation | RAIRLANSTASVSRG HHHHHHHCCCCCCCC | 21.53 | 29899451 | |
| 548 | Phosphorylation | AIRLANSTASVSRGS HHHHHHCCCCCCCCC | 23.82 | 21454597 | |
| 550 | Phosphorylation | RLANSTASVSRGSMQ HHHHCCCCCCCCCHH | 22.25 | 19060867 | |
| 552 | Phosphorylation | ANSTASVSRGSMQEL HHCCCCCCCCCHHHH | 28.55 | 22807455 | |
| 555 | Phosphorylation | TASVSRGSMQELDTL CCCCCCCCHHHHHHH | 19.04 | 25521595 | |
| 561 | Phosphorylation | GSMQELDTLAGLRRS CCHHHHHHHHHHCCC | 31.00 | 29899451 | |
| 568 | Phosphorylation | TLAGLRRSPAPQTRS HHHHHCCCCCCCCHH | 20.98 | 29899451 | |
| 584 | Phosphorylation | LNAKPHDSLDLNCDS CCCCCCCCCCCCCCC | 22.28 | - | |
| 634 | Phosphorylation | PNTTLRNSSLGTPCL CCCCCCCCCCCCCCC | 22.10 | 29899451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KCND1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KCND1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KCND1_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of KCND1_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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