dbPTM

KCNC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KCNC3_HUMAN
UniProt AC	Q14003
Protein Name	Potassium voltage-gated channel subfamily C member 3
Gene Name	KCNC3
Organism	Homo sapiens (Human).
Sequence Length	757
Subcellular Localization	Cell membrane Multi-pass membrane protein . Cell junction, synapse, presynaptic cell membrane Multi-pass membrane protein . Perikaryon . Cell projection, axon . Cell projection, dendrite . Cell projection, dendritic spine membrane Multi-pass membran
Protein Description	Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics. [PubMed: 10712820]
Protein Sequence	MLSSVCVSSFRGRQGASKQQPAPPPQPPESPPPPPLPPQQQQPAQPGPAASPAGPPAPRGPGDRRAEPCPGLPAAAMGRHGGGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGADEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPPGGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPNYCKPDPPPPPPPHPHHGSGGISPPPPITPPSMGVTVAGAYPAGPHTHPGLLRGGAGGLGIMGLPPLPAPGEPCPLAQEEVIEINRADPRPNGDPAAAALAHEDCPAIDQPAMSPEDKSPITPGSRGRYSRDRACFLLTDYAPSPDGSIRKATGAPPLPPQDWRKPGPPSFLPDLNANAAAWISP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MLSSVCVSSF -----CCCCHHHHHC	21.30	30206219
4	Phosphorylation	----MLSSVCVSSFR ----CCCCHHHHHCC	18.64	30206219
8	Phosphorylation	MLSSVCVSSFRGRQG CCCCHHHHHCCCCCC	20.73	30206219
9	Phosphorylation	LSSVCVSSFRGRQGA CCCHHHHHCCCCCCC	9.88	30206219
101	Phosphorylation	VGGVRHETYRSTLRT ECCCCCCHHHHHHHC	20.36	-
102	Phosphorylation	GGVRHETYRSTLRTL CCCCCCHHHHHHHCC	10.28	-
243	Ubiquitination	DGAGGELKRLCFQDA CCCCCHHHHHEEECC	38.74	-
320	N-linked_Glycosylation	EGFIHISNKTVTQAS CCEEEECCCEEEECC	43.33	UniProtKB CARBOHYD
336	N-linked_Glycosylation	IPGAPPENITNVEVE CCCCCCCCCCCEEEE	52.75	UniProtKB CARBOHYD
370	S-nitrosylation	FLMRITFCPDKVEFL HHHHHHCCCCHHHHH	2.97	19483679
370	S-nitrosocysteine	FLMRITFCPDKVEFL HHHHHHCCCCHHHHH	2.97	-
379	Phosphorylation	DKVEFLKSSLNIIDC CHHHHHHHHCCHHHH	42.05	-
380	Phosphorylation	KVEFLKSSLNIIDCV HHHHHHHHCCHHHHH	24.69	-
399	Phosphorylation	FYLEVGLSGLSSKAA HHHHHCCCCCCHHHH	31.59	-
483	N-linked_Glycosylation	PDDILGSNHTYFKNI HHHCCCCCCCCCCCC	29.71	UniProtKB CARBOHYD
574	Phosphorylation	PQPGSPNYCKPDPPP CCCCCCCCCCCCCCC	12.77	18083107
625	Methylation	HTHPGLLRGGAGGLG CCCCCCCCCCCCCCC	46.68	-
686	Phosphorylation	AIDQPAMSPEDKSPI CCCCCCCCCCCCCCC	27.52	-
691	Phosphorylation	AMSPEDKSPITPGSR CCCCCCCCCCCCCCC	33.58	26330541
694	Phosphorylation	PEDKSPITPGSRGRY CCCCCCCCCCCCCCC	25.61	26330541
725	Phosphorylation	DGSIRKATGAPPLPP CCCCCCCCCCCCCCC	36.59	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KCNC3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KCNC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KCNC3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of KCNC3_HUMAN !!

Drug and Disease Associations

Kegg Disease
H00063	Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
OMIM Disease
605259	Spinocerebellar ataxia 13 (SCA13)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB06637	Dalfampridine

Regulatory Network of KCNC3_HUMAN

Related Literatures of Post-Translational Modification