KCNC2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCNC2_RAT
• UniProt AC: P22462
• Protein Name: Potassium voltage-gated channel subfamily C member 2 {ECO:0000312|RGD:628829}
• Gene Name: Kcnc2 {ECO:0000312|RGD:628829}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 638
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Membrane ; Multi-pass membrane protein . Perikaryon . Cell projection, axon . Cell junction, synapse . Cell junction, synapse, synaptosome . Cell projection, dendrite . Cell junction, synapse, postsynaptic cel
• Protein Description: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. [PubMed: 10482766]
• Protein Sequence: MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPQGDCLTAAGDKLQPLPPPLSPPPRPPPLSPVPSGCFEGGAGNCSSHGGNGSDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPGDDEDLGGKRLGIEDAAGLGGPDGKSGRWRKLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSAVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPLASSPTFCKTELNMACNSTQSDTCLGKENRLLEHNRSVLSGDDSTGSEPPLSPPERLPIRRSSTRDKNRRGETCFLLTTGDYTCASDGGIRKGYEKSRSLNNIAGLAGNALRLSPVTSPYNSPCPLRRSRSPIPSIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
62	Phosphorylation	QPLPPPLSPPPRPPP CCCCCCCCCCCCCCC	40.93	28551015
204	Ubiquitination	GLGGPDGKSGRWRKL CCCCCCCCCCHHHHC	58.05	-
259	N-linked_Glycosylation	EAFNIVKNKTEPVIN HHHHHHCCCCCCCCC	45.66	-
266	N-linked_Glycosylation	NKTEPVINGTSAVLQ CCCCCCCCCCEEEEE	48.18	-
564	Phosphorylation	RLPIRRSSTRDKNRR CCCCCCCCCCCCCCC	26.17	-
595 (in isoform 2)	Phosphorylation	-	24.18	29779826
600	Phosphorylation	KGYEKSRSLNNIAGL CCHHHHHCHHHHHHH	42.41	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
564	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCNC2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCNC2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of KCNC2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.