KCNAL_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCNAL_DROME
• UniProt AC: P17971
• Protein Name: Potassium voltage-gated channel protein Shal
• Gene Name: Shal
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 571
• Subcellular Localization: Membrane; Multi-pass membrane protein. Cell projection, dendrite. Perikaryon.
• Protein Description: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. May play a role in the nervous system and in the regulation of beating frequency in pacemaker cells..
• Protein Sequence: MASVAAWLPFARAAAIGWVPIATHPLPPPPMPKDRRKTDDEKLLINVSGRRFETWRNTLEKYPDTLLGSNEREFFYDEDCKEYFFDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDKLSENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVPCGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAIMPYYIGLGITDNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKASSGAAFVSKKKAAEARWAAQESGIELDDNYRDEDIFELQHHHLLRCLEKTTDREFVELEIPFNGQPKRPGSPSPMASPAHSTNSAAGLLQSCCGRCCSQRYQACGKYMPAASNAQNSQNNQPMDGTYLVEASF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	N-linked_Glycosylation	DDEKLLINVSGRRFE CCCCEEEECCCCCHH	23.13	-
350	N-linked_Glycosylation	FYAEKNVNGTNFTSI HHHHHCCCCCCCCCC	62.05	-
353	N-linked_Glycosylation	EKNVNGTNFTSIPAA HHCCCCCCCCCCCHH	39.33	-
408	N-linked_Glycosylation	PVPVIVSNFSRIYHQ ECCEEECCHHHHHHH	28.19	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCNAL_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCNAL_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCNAL_DROME !!

Protein-Protein Interaction

Oops, there are no PPI records of KCNAL_DROME !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.