KCJ15_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCJ15_MOUSE
• UniProt AC: O88932
• Protein Name: ATP-sensitive inward rectifier potassium channel 15
• Gene Name: Kcnj15
• Organism: Mus musculus (Mouse).
• Sequence Length: 375
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium..
• Protein Sequence: MDAIHLGMSSAPLVKHTNGVGLKAHRPRVMSKSGHSNVRIDKVDGIYLLYLQDLWTTVIDMKWRYKLTLFAATFVMTWFLFGVVYYAIAFIHGDLQLGESNSNHTPCIMKVDSLTGAFLFSLESQTTIGYGVRSITEECPHAIFLLVAQLVITTLIEIFITGTFLAKIARPKKRAETIKFSHCAVISKQNGKLCLVIQVANMRKSLLIQCQLSGKLLQTHVTKEGERILLNQATVKFHVDSSSESPFLILPMTFYHVLDETSPLRDLTPQNLKEKEFELVVLLNATVESTSAVCQSRTSYIPEEIYWGFEFVPVVSLSKNGKYVADFSQFEQIRKSPDCTFYCADSEKQKLEEQYRQEDQRERELRSLLLQQSNV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Ubiquitination	MSSAPLVKHTNGVGL CCCCCCCCCCCCCCC		-
172	Acetylation	LAKIARPKKRAETIK HHHHHCCCCCCCEEC		19853197
173	Acetylation	AKIARPKKRAETIKF HHHHCCCCCCCEECC		19853405
213	Phosphorylation	LLIQCQLSGKLLQTH HHHHHHHCCCEEEEE		21454597
222	Phosphorylation	KLLQTHVTKEGERIL CEEEEEECCCCCEEE		21454597
223	Ubiquitination	LLQTHVTKEGERILL EEEEEECCCCCEEEE		-
335	Ubiquitination	SQFEQIRKSPDCTFY HHHHHHHCCCCCEEE		-
348	Ubiquitination	FYCADSEKQKLEEQY EEECCHHHHHHHHHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCJ15_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCJ15_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCJ15_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IL16_MOUSE	Il16	physical	10479680

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.