KCIP2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCIP2_RAT
• UniProt AC: Q9JM59
• Protein Name: Kv channel-interacting protein 2
• Gene Name: Kcnip2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 270
• Subcellular Localization: Cell membrane ; Lipid-anchor . Detected on lipid rafts.
• Protein Description: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. [PubMed: 16820361 In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. Essential for the expression of I(To) currents in the heart (By similarity Required for normal protein levels of KCND2 in the heart ventricle (By similarity]
• Protein Sequence: MRGQGRKESLSESRDLDGSYDQLTGHPPGPSKKALKQRFLKLLPCCGPQALPSVSETLAAPASLRPHRPRPLDPDSVEDEFELSTVCHRPEGLEQLQEQTKFTRRELQVLYRGFKNECPSGIVNEENFKQIYSQFFPQGDSSNYATFLFNAFDTNHDGSVSFEDFVAGLSVILRGTIDDRLSWAFNLYDLNKDGCITKEEMLDIMKSIYDMMGKYTYPALREEAPREHVESFFQKMDRNKDGVVTIEEFIESCQQDENIMRSMQLFDNVI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	RGQGRKESLSESRDL CCCCCCCCCCCCCCC	39.98	25403869
11	Phosphorylation	QGRKESLSESRDLDG CCCCCCCCCCCCCCC	42.69	24972320
19	Phosphorylation	ESRDLDGSYDQLTGH CCCCCCCCCHHHCCC	25.79	30240740
20	Phosphorylation	SRDLDGSYDQLTGHP CCCCCCCCHHHCCCC	17.15	22673903
45	S-palmitoylation	RFLKLLPCCGPQALP HHHHHHCCCCCCCCC	4.17	12006572
46	S-palmitoylation	FLKLLPCCGPQALPS HHHHHCCCCCCCCCC	9.34	12006572

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCIP2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCIP2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCIP2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of KCIP2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Palmitoylation

"Palmitoylation of KChIP splicing variants is required for efficientcell surface expression of Kv4.3 channels.";
Takimoto K., Yang E.-K., Conforti L.;
J. Biol. Chem. 277:26904-26911(2002).
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), SUBCELLULARLOCATION, TISSUE SPECIFICITY, PALMITOYLATION AT CYS-45 AND CYS-46, ANDMUTAGENESIS OF 45-CYS-CYS-46.
PubMed: 12006572