dbPTM

KCC1B_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KCC1B_RAT
UniProt AC	O70150
Protein Name	Calcium/calmodulin-dependent protein kinase type 1B
Gene Name	Pnck
Organism	Rattus norvegicus (Rat).
Sequence Length	343
Subcellular Localization	Cytoplasm. Nucleus.
Protein Description	Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro, isoform 1 and isoform 2 phosphorylate CREB1, SYN1/synapsin I. Phosphorylates and activates CAMK1..
Protein Sequence	MLLLKKQTEDISSVYEIREKLGSGAFSEVMLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALQHLWISGDAALDRDILGSVSEQIQKNFARTHWKRAFNATSFLRHIRKLGQSPEGEEASRQGMTRHSHPGLGTSQSPKW

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	Ubiquitination	PKKALRGKEALVENE CHHHHCCCHHHHHCH	33.12	-
257	Ubiquitination	LLERDPQKRFTCQQA HHHHCHHHCCCHHHH	55.67	-
304	Phosphorylation	WKRAFNATSFLRHIR HHHHHHHHHHHHHHH	22.55	28432305
305	Phosphorylation	KRAFNATSFLRHIRK HHHHHHHHHHHHHHH	21.63	25403869
316	Phosphorylation	HIRKLGQSPEGEEAS HHHHHCCCCCCHHHH	24.10	28551015
323	Phosphorylation	SPEGEEASRQGMTRH CCCCHHHHHCCCCCC	28.54	28551015
337	Phosphorylation	HSHPGLGTSQSPKW- CCCCCCCCCCCCCC-	28.74	22673903
338	Phosphorylation	SHPGLGTSQSPKW-- CCCCCCCCCCCCC--	27.19	22673903
340	Phosphorylation	PGLGTSQSPKW---- CCCCCCCCCCC----	28.37	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KCC1B_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KCC1B_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KCC1B_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of KCC1B_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KCC1B_RAT

Related Literatures of Post-Translational Modification