| UniProt ID | KCC1B_HUMAN | |
|---|---|---|
| UniProt AC | Q6P2M8 | |
| Protein Name | Calcium/calmodulin-dependent protein kinase type 1B | |
| Gene Name | PNCK | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 343 | |
| Subcellular Localization | Cytoplasm. Nucleus. | |
| Protein Description | Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity).. | |
| Protein Sequence | MLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAFNATSFLRHIRKLGQIPEGEGASEQGMARHSHSGLRAGQPPKW | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 15 (in isoform 6) | Phosphorylation | - | 13.95 | 22210691 | |
| 25 (in isoform 6) | Phosphorylation | - | 13.39 | 22210691 | |
| 27 (in isoform 5) | Phosphorylation | - | 29.02 | - | |
| 29 (in isoform 6) | Phosphorylation | - | 4.07 | 22210691 | |
| 30 (in isoform 6) | Phosphorylation | - | 3.00 | 22210691 | |
| 54 | Ubiquitination | PKKALRGKEALVENE CHHHHCCCHHHHHCH | 33.12 | 30230243 | |
| 71 | Ubiquitination | VLRRISHPNIVALED HHHHCCCCCEEEECC | 26.00 | 30230243 | |
| 74 (in isoform 5) | Phosphorylation | - | 6.72 | - | |
| 114 | Phosphorylation | SYTEKDASHLVGQVL CCCHHHHHHHHHHHH | 27.73 | 24719451 | |
| 126 | Phosphorylation | QVLGAVSYLHSLGIV HHHHHHHHHHHHCCC | 11.22 | 24719451 | |
| 137 | Ubiquitination | LGIVHRDLKPENLLY HCCCCCCCCHHHCEE | 11.41 | 30230243 | |
| 138 | Ubiquitination | GIVHRDLKPENLLYA CCCCCCCCHHHCEEE | 55.35 | 30230243 | |
| 155 | Ubiquitination | FEDSKIMVSDFGLSK CCCCCEEECCCCCCC | 5.90 | 30230243 | |
| 171 | Phosphorylation | QAGNMLGTACGTPGY CCCCCCCCCCCCCCC | 18.14 | 28857561 | |
| 221 | Ubiquitination | DESDPELFSQILRAS CCCCHHHHHHHHHHH | 4.88 | 30230243 | |
| 229 | Phosphorylation | SQILRASYEFDSPFW HHHHHHHCCCCCCCC | 21.45 | - | |
| 283 | Phosphorylation | FDRDILGSVSEQIRK CCHHHHHHHHHHHHH | 21.01 | 28857561 | |
| 304 | Phosphorylation | WKRAFNATSFLRHIR HHHHHHHHHHHHHHH | 22.55 | 24719451 | |
| 305 | Phosphorylation | KRAFNATSFLRHIRK HHHHHHHHHHHHHHH | 21.63 | 28857561 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KCC1B_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KCC1B_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KCC1B_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of KCC1B_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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