KATL2_HUMAN - dbPTM
KATL2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KATL2_HUMAN
UniProt AC Q8IYT4
Protein Name Katanin p60 ATPase-containing subunit A-like 2 {ECO:0000255|HAMAP-Rule:MF_03025}
Gene Name KATNAL2 {ECO:0000255|HAMAP-Rule:MF_03025}
Organism Homo sapiens (Human).
Sequence Length 538
Subcellular Localization Cytoplasm, cytoskeleton . Cytoplasm . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, spindle pole . Localizes within the cytoplasm, partially overlapping with microtubules in interphase and to the mitotic spindle and spindle poles during
Protein Description Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays..
Protein Sequence MELSYQTLKFTHQAREACEMRTEARRKNLLILISHYLTQEGYIDTANALEQETKLGLRRFEVCDNIDLETILMEYESYYFVKFQKYPKIVKKSSDTAENNLPQRSRGKTRRMMNDSCQNLPKINQQRPRSKTTAGKTGDTKSLNKEHPNQEVVDNTRLESANFGLHISRIRKDSGEENAHPRRGQIIDFQGLLTDAIKGATSELALNTFDHNPDPSERLLKPLSAFIGMNSEMRELAAVVSRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLRRLEKRILVDLPSREARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPVRKIFDALENHQSESSDLPRIQLDIVTTADFLDVLTHTKPSAKNLAQRYSDWQREFESV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
37PhosphorylationLILISHYLTQEGYID
HHHHHHHHHHCCCCC		3.1418491316
102PhosphorylationDTAENNLPQRSRGKT
CCHHHCCCCHHHHHH		29.6627251275
109PhosphorylationPQRSRGKTRRMMNDS
CCHHHHHHHHHHCHH		26.7418491316
116PhosphorylationTRRMMNDSCQNLPKI
HHHHHCHHHHCCCHH		16.7629083192
174PhosphorylationISRIRKDSGEENAHP
HHHECCCCCCCCCCC		51.6527251275
189UbiquitinationRRGQIIDFQGLLTDA
CCCCEEEHHHHHHHH		4.3523000965
194UbiquitinationIDFQGLLTDAIKGAT
EEHHHHHHHHHHHHC		28.5523000965
227UbiquitinationLKPLSAFIGMNSEMR
HHHHHHHHCCCHHHH		5.2423000965
228UbiquitinationKPLSAFIGMNSEMRE
HHHHHHHCCCHHHHH		11.6323000965
232UbiquitinationAFIGMNSEMRELAAV
HHHCCCHHHHHHHHH		36.9423000965
233UbiquitinationFIGMNSEMRELAAVV
HHCCCHHHHHHHHHH		3.9623000965
263UbiquitinationIIGLDAAKQLVKEAV
CCCHHHHHHHHHHHC		45.98-
276PhosphorylationAVVYPIRYPQLFTGI
HCCCCCCCHHHHCCC		8.9624425749
285PhosphorylationQLFTGILSPWKGLLL
HHHCCCCCCCCCEEE		27.1324425749
293PhosphorylationPWKGLLLYGPPGTGK
CCCCEEECCCCCCCH		27.7928152594
298PhosphorylationLLYGPPGTGKTLLAK
EECCCCCCCHHHHHH		41.0828152594
300UbiquitinationYGPPGTGKTLLAKAV
CCCCCCCHHHHHHHH		35.5223000965
305UbiquitinationTGKTLLAKAVATECK
CCHHHHHHHHHHCCC		43.2823000965
325UbiquitinationISASTIVSKWRGDSE
ECHHHHHHHCCCCHH		23.7323000965
326UbiquitinationSASTIVSKWRGDSEK
CHHHHHHHCCCCHHH		29.9823000965
330UbiquitinationIVSKWRGDSEKLVRV
HHHHCCCCHHHHHHH		45.0823000965
331UbiquitinationVSKWRGDSEKLVRVL
HHHCCCCHHHHHHHH		39.1823000965
331PhosphorylationVSKWRGDSEKLVRVL
HHHCCCCHHHHHHHH		39.1817081983
435PhosphorylationRQAMIYHWLPPVSKS
HHHHHHHHCCCCCHH		8.1324719451
445PhosphorylationPVSKSRALELHTELE
CCCHHHHHHHHHHHE		7.5624719451
463PhosphorylationLSQETEGYSGSDIKL
CCCCCCCCCCCCHHH		12.0224275569
507PhosphorylationIQLDIVTTADFLDVL
EEEEEEEHHHHHHHH		17.2124719451
517PhosphorylationFLDVLTHTKPSAKNL
HHHHHHCCCCCHHHH		39.1424719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KATL2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KATL2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KATL2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of KATL2_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KATL2_HUMAN

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Related Literatures of Post-Translational Modification

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