dbPTM

KAP3_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KAP3_RAT
UniProt AC	P12369
Protein Name	cAMP-dependent protein kinase type II-beta regulatory subunit
Gene Name	Prkar2b
Organism	Rattus norvegicus (Rat).
Sequence Length	416
Subcellular Localization	Cytoplasm. Cell membrane. Colocalizes with PJA2 in the cytoplasm and at the cell membrane..
Protein Description	Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase..
Protein Sequence	MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGAARFGHEGRTWGDAGAAAGGGTPSKGVNFAEEPMRSDSENGEEEEAAEAGAFNAPVINRFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVRITMKRKGKSDIEENGAVEIARCLRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
69	Phosphorylation	GAAAGGGTPSKGVNF CHHCCCCCCCCCCCC	27.88	30411139
71	Phosphorylation	AAGGGTPSKGVNFAE HCCCCCCCCCCCCCC	41.71	27097102
83	Phosphorylation	FAEEPMRSDSENGEE CCCCCCCCCCCCCCH	38.96	27097102
85	Phosphorylation	EEPMRSDSENGEEEE CCCCCCCCCCCCHHH	33.92	27097102
112	Phosphorylation	NRFTRRASVCAEAYN HHHHHHHHCHHHHHC	18.87	23712012
118	Phosphorylation	ASVCAEAYNPDEEED HHCHHHHHCCCCCCC	20.80	30240740
162	Phosphorylation	NLDPEQMSQVLDAMF CCCHHHHHHHHHHHH	19.48	-
174	Acetylation	AMFEKLVKEGEHVID HHHHHHHHCCCCEEC	71.13	22902405
174	Ubiquitination	AMFEKLVKEGEHVID HHHHHHHHCCCCEEC	71.13	-
285	Acetylation	LEVSERLKVVDVIGT CCHHHCCEEEEEECC	46.57	22902405
357	Acetylation	ELALVTNKPRAASAH EEEEECCCCCCCHHH	26.89	44859101
357	Ubiquitination	ELALVTNKPRAASAH EEEEECCCCCCCHHH	26.89	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KAP3_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KAP3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KAP3_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of KAP3_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KAP3_RAT

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomics of vasopressin-sensitive renal cells:regulation of aquaporin-2 phosphorylation at two sites."; Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.; Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-112, AND MASSSPECTROMETRY.	16641100 [Abstract]