KALM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KALM_HUMAN
• UniProt AC: P23352
• Protein Name: Anosmin-1 {ECO:0000303|PubMed:8832397, ECO:0000312|HGNC:HGNC:6211}
• Gene Name: ANOS1 {ECO:0000312|HGNC:HGNC:6211}
• Organism: Homo sapiens (Human).
• Sequence Length: 680
• Subcellular Localization: Cell membrane ; Peripheral membrane protein . Secreted . Proteolytic cleavage may release it from the cell surface into the extracellular space.
• Protein Description: Has a dual branch-promoting and guidance activity, which may play an important role in the patterning of mitral and tufted cell collaterals to the olfactory cortex (By similarity). Chemoattractant for fetal olfactory epithelial cells..
• Protein Sequence: MVPGVPGAVLTLCLWLAASSGCLAAGPGAAAARRLDESLSAGSVQRARCASRCLSLQITRISAFFQHFQNNGSLVWCQNHKQCSKCLEPCKESGDLRKHQCQSFCEPLFPKKSYECLTSCEFLKYILLVKQGDCPAPEKASGFAAACVESCEVDNECSGVKKCCSNGCGHTCQVPKTLYKGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTTDGFQNSVILEKLQPDCDYVVELQAITYWGQTRLKSAKVSLHFTSTHATNNKEQLVKTRKGGIQTQLPFQRRRPTRPLEVGAPFYQDGQLQVKVYWKKTEDPTVNRYHVRWFPEACAHNRTTGSEASSGMTHENYIILQDLSFSCKYKVTVQPIRPKSHSKAEAVFFTTPPCSALKGKSHKPVGCLGEAGHVLSKVLAKPENLSASFIVQDVNITGHFSWKMAKANLYQPMTGFQVTWAEVTTESRQNSLPNSIISQSQILPSDHYVLTVPNLRPSTLYRLEVQVLTPGGEGPATIKTFRTPELPPSSAHRSHLKHRHPHHYKPSPERY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	RRLDESLSAGSVQRA HHHHHCCCCCHHHHH	39.60	23403867
43	Phosphorylation	DESLSAGSVQRARCA HHCCCCCHHHHHHHH	18.13	26437602
71	N-linked_Glycosylation	FFQHFQNNGSLVWCQ HHHHHHHCCCEEEEC	30.55	UniProtKB CARBOHYD
179	Phosphorylation	CQVPKTLYKGVPLKP CCCCCCEECCCCCCC	15.78	22817900
209	N-linked_Glycosylation	VKWSSKFNISIEPVI EEEECCCCCEEECEE	30.73	UniProtKB CARBOHYD
211	Phosphorylation	WSSKFNISIEPVIYV EECCCCCEEECEEEE	23.23	-
217	Phosphorylation	ISIEPVIYVVQRRWN CEEECEEEEEECCCC	8.53	-
259	Phosphorylation	DIRPSRWYQFRVAAV CCCCCCCEEEEEEEE	9.18	22817900
300	N-linked_Glycosylation	PANLRLANSTVNSDG CCCEEECCCEECCCC	42.69	UniProtKB CARBOHYD
339	Acetylation	WSWMVSSKSLVPTKK HHHHHCCCCCCCCCC	40.06	30589625
344	Phosphorylation	SSKSLVPTKKKRRKT CCCCCCCCCCCCCCC	48.28	-
351	Phosphorylation	TKKKRRKTTDGFQNS CCCCCCCCCCCCCCC	28.45	28258704
352	Phosphorylation	KKKRRKTTDGFQNSV CCCCCCCCCCCCCCH	36.84	28258704
450	Phosphorylation	VKVYWKKTEDPTVNR EEEEEEECCCCCCCE	41.72	-
470	N-linked_Glycosylation	FPEACAHNRTTGSEA CHHHHHCCCCCCCCC	25.19	UniProtKB CARBOHYD
553	N-linked_Glycosylation	KVLAKPENLSASFIV HHHCCCCCCCEEEEE	48.07	UniProtKB CARBOHYD
564	N-linked_Glycosylation	SFIVQDVNITGHFSW EEEEECCCCCCEEEH	34.10	UniProtKB CARBOHYD
579	Phosphorylation	KMAKANLYQPMTGFQ HHHHCCCCCCCCCEE	15.46	-
652	Phosphorylation	ATIKTFRTPELPPSS EEEEEEECCCCCCCH	19.54	-
676	Phosphorylation	HPHHYKPSPERY--- CCCCCCCCCCCC---	34.93	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KALM_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KALM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KALM_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SDC2_HUMAN	SDC2	physical	8832397

Drug and Disease Associations

• Kegg Disease
• H00255: Hypogonadotropic hypogonadism, including: Kallmann syndrome (KAL); Fertile eunuch syndrome (FEUNS)
• OMIM Disease
• 308700: Hypogonadotropic hypogonadism 1 with or without anosmia (HH1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.