K0319_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K0319_MOUSE
• UniProt AC: Q5SZV5
• Protein Name: Dyslexia-associated protein KIAA0319 homolog
• Gene Name: Kiaa0319
• Organism: Mus musculus (Mouse).
• Sequence Length: 1081
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Early endosome membrane ; Single-pass type I membrane protein .
• Protein Description: Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites (By similarity)..
• Protein Sequence: MVSPPGVLSSLLLLAAMAGGSSQQCSEGRTYSDAIISPNPETIRIMRVSQTFSVGDCTAACCDLLTCDLAWWFEGSCYLVKCMRSENCEPRTTGPIRSYLTFVRRPVQRPGQLLDYGDMMLSRGSPSGAWGDSLEDLRKDLPFLGKDGGPEETTEYSDEYKDLERGLLQPSNQQDPRGSAEYPDWSLLPSNEGGFNATATGDNSAASMEKLQDPTPHPLDQEQLQALNESTWSPTPGHSSISSVWPSSASPLPTEEGLEGEETLQLQEQPSNSSGKEVPMPSHNPSPASLESSPATTEKNSNFTVTPRSRKHSTPTFPTSTVLTGLTPPPWPLSPTASRTVKALAVSAGDNLVLTLPDREAELKASVEPAPPADTTYSYEWSLMSHPVDFQGKIKQENKPTLHLSQLSVGLYAFRVAVSSENAFGEGYVNVTVMPAARVNQPPVAVVSPQTQELSVPLTSALIDGSQSTDDTEIVSYHWEEVDGPFLGEEFPADTPILRLSNLVPGNYTFRLTITDSDGATNSTTASLVIRDAVDYPPVANAGPNQTITLPQNTIILNGNQSSDDHQIVLYEWFAGPGGESKEMVMQGAQTPYLHLSELQEGEYTFQLMVTDSSGQQSTALVAVTVQAENNQAPVAVAGPDKELVFPVQSATLDGSRSSDDHGIVCYHWEHIRGPSAVEMENVDKAIATVTGLQVGIYHFRLTVRDQQGLSSTSTLTVAVKKENNSPPRAQAGGRHVLILPNNSITLDGSRSTDDRGIVSYLWIRDGQSPAAGDVIGGSDHRAALQLTNLVEGVYTFHLLVTDSQGASDSDAATVEVLPDPKKDGLVELILQVGVEQLTEQQKETLVRQLAVLLNVLDSDVKVLKIQAHTDVSTVIVFYVQSGSPFKVLRAAAVARNLHKRLSKEKEAFLLFKVLRVDTAGCLLKCSGHGHCDPITKRCICSQLWMENLIQRYMWDGESNCEWSVFYVAALALTLTLLTGAVSWLCICCCRRRKRTKIRKKTKYTILDSMDEQERMELRPKYGIKHRSTEHNSSLMVSESEFESDQDTLFSRERMERGVLKGSLNGCARNGVSFGYYSKDR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Phosphorylation	IISPNPETIRIMRVS EECCCHHCEEEEEEE	19.47	24759943
133	Phosphorylation	PSGAWGDSLEDLRKD CCCCCCCCHHHHHHH	29.71	23737553
196	N-linked_Glycosylation	PSNEGGFNATATGDN CCCCCCCCCEECCCC	39.39	-
228	N-linked_Glycosylation	QEQLQALNESTWSPT HHHHHHHHHCCCCCC	44.16	-
272	N-linked_Glycosylation	QLQEQPSNSSGKEVP ECEECCCCCCCCCCC	47.05	-
302	N-linked_Glycosylation	ATTEKNSNFTVTPRS CCCCCCCCEEECCCC	46.10	-
430	N-linked_Glycosylation	AFGEGYVNVTVMPAA CCCCCEEEEEEEECC	18.43	-
507	N-linked_Glycosylation	LSNLVPGNYTFRLTI ECCCCCCCEEEEEEE	26.97	-
522	N-linked_Glycosylation	TDSDGATNSTTASLV ECCCCCCCCCEEEEE	36.50	-
545	N-linked_Glycosylation	PVANAGPNQTITLPQ CCCCCCCCCEEEECC	51.19	-
560	N-linked_Glycosylation	NTIILNGNQSSDDHQ CEEEECCCCCCCCCE	37.17	-
713	Phosphorylation	DQQGLSSTSTLTVAV CCCCCCCCEEEEEEE	23.50	27566939
714	Phosphorylation	QQGLSSTSTLTVAVK CCCCCCCEEEEEEEE	24.30	27566939
742	N-linked_Glycosylation	RHVLILPNNSITLDG CEEEECCCCCEEECC	51.97	-
1009	Phosphorylation	TKYTILDSMDEQERM CCEEECCCCCHHHHH	25.37	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K0319_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of K0319_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K0319_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of K0319_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.