JUPI1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: JUPI1_RAT
• UniProt AC: Q6AXU6
• Protein Name: Jupiter microtubule associated homolog 1 {ECO:0000250|UniProtKB:Q9UK76}
• Gene Name: JPT1 {ECO:0000250|UniProtKB:Q9UK76}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 149
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions. Plays a role in the regulation of cell cycle and cell adhesion. Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation..
• Protein Sequence: MTTTTTFKGVDPNSRNSSRVLRPPGGGSNFSLGFDEPTEQPVRKNKMASNIFGTPEENPPSWAKSAGGREDSESPGTQRSNSSEASSGDFLDLKGESDVHENVDTDFQASLAQVEEKPVPAAPVPSPVAPAPAPSRRNPPGGKSSLVLG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MTTTTTFK -------CCCEEEEC		-
2	Acetylation	------MTTTTTFKG ------CCCEEEECC		-
8	Acetylation	MTTTTTFKGVDPNSR CCCEEEECCCCCCCC		22902405
14	Phosphorylation	FKGVDPNSRNSSRVL ECCCCCCCCCCCCEE		28432305
17	Phosphorylation	VDPNSRNSSRVLRPP CCCCCCCCCCEECCC		28432305
18	Phosphorylation	DPNSRNSSRVLRPPG CCCCCCCCCEECCCC		28432305
28	Phosphorylation	LRPPGGGSNFSLGFD ECCCCCCCCCCCCCC		28432305
31	Phosphorylation	PGGGSNFSLGFDEPT CCCCCCCCCCCCCCC		28432305
49	Phosphorylation	VRKNKMASNIFGTPE CHHHCCHHHCCCCCC		30181290
54	Phosphorylation	MASNIFGTPEENPPS CHHHCCCCCCCCCCH		27097102
61	Phosphorylation	TPEENPPSWAKSAGG CCCCCCCHHHHHCCC		30181290
72	Phosphorylation	SAGGREDSESPGTQR HCCCCCCCCCCCCCC		28551015
74	Phosphorylation	GGREDSESPGTQRSN CCCCCCCCCCCCCCC		27097102
77	Phosphorylation	EDSESPGTQRSNSSE CCCCCCCCCCCCCCC		28551015
80	Phosphorylation	ESPGTQRSNSSEASS CCCCCCCCCCCCCCC		27097102
82	Phosphorylation	PGTQRSNSSEASSGD CCCCCCCCCCCCCCC		23712012
83	Phosphorylation	GTQRSNSSEASSGDF CCCCCCCCCCCCCCC		27097102
86	Phosphorylation	RSNSSEASSGDFLDL CCCCCCCCCCCCCCC		27097102
87	Phosphorylation	SNSSEASSGDFLDLK CCCCCCCCCCCCCCC		27097102
126	Phosphorylation	VPAAPVPSPVAPAPA CCCCCCCCCCCCCCC		27097102
143	Acetylation	RRNPPGGKSSLVLG- CCCCCCCCCCCCCC-		22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of JUPI1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of JUPI1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of JUPI1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of JUPI1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.