JPH4_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: JPH4_RAT
• UniProt AC: Q69FB3
• Protein Name: Junctophilin-4
• Gene Name: Jph4 {ECO:0000312|RGD:1303170}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 630
• Subcellular Localization: Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein . Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-ter
• Protein Description: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity)..
• Protein Sequence: MHVPLGRKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGFESLGVFTGPGGHSYQGHWQQGKREGLGVERKSRWTYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYGVRQSVPYHQAALLRSPRRTSLDSGHSDPPTPPPPLPLPGDEGGSPASGSRGGFVLAGPGDADGASSRKRTPAAGGFFRRSLLLSGLRAGGRRSSLGSKRGSLRSEVSSEVGSTGPPGSEASGPPIPAPPALIEGSATEVYAGEWRADRRSGYGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKRNRLVHGGRVRSLLPLALRRGKVKEKVDRAVEGARRAVSAARQRQEIAAARAADALLKAVAASSVAEKAVEAARMAKLIAQDLQPMLEAPGRRPRQDSGGSDTEPLDEDSPGVYENGLTPSEGSPELPSSPASSHQPWRAPPCRSPLPPGGNWGPFSSPKAWPEEWGGPGEQAEELAGYEAEDEAGMQGPGPRDGSPLLGGCSDSSGSLREEEGEDEESLPQLRAPGGSESEPVTTPVLRGLSSRGPDAGCLTEEFEEPAATERPAQPGAANPLVVGAVALLDLSLAFLFSQLLT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
159	Phosphorylation	HQAALLRSPRRTSLD HHHHHHCCCCCCCCC	23.80	28432305
224	Phosphorylation	AGGFFRRSLLLSGLR CCCHHHHHHHHHCCC	21.07	28432305
238	Phosphorylation	RAGGRRSSLGSKRGS CCCCCCHHCCCCCCC	34.63	25403869
403	Ubiquitination	AASSVAEKAVEAARM HHHHHHHHHHHHHHH	48.25	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of JPH4_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of JPH4_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of JPH4_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of JPH4_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.