JMJ18_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: JMJ18_ARATH
• UniProt AC: F4I6G4
• Protein Name: Lysine-specific demethylase JMJ18
• Gene Name: JMJ18
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 819
• Subcellular Localization: Nucleus .
• Protein Description: Histone demethylase that demethylates 'Lys-4' (H3K4me) of histone H3 with a specific activity for H3K4me3 and H3K4me2. No activity on H3K9me3/2, H3K27me3/2 and H3K36me3/2. Involved in the control of flowering time by demethylating H3K4me3 at the FLC locus and repressing its expression. The repression of FLC level and reduction in H3K4me3 at the FLC locus results in induction of the flowering activator FT, which is a downstream target of FLC..
• Protein Sequence: MENPPLESEIKEDMSLKNHPPDKDKDKDTIMEQPSSPRHRKVVARWLPDEAQRPIINDAPVFTPSLEEFVDPLAYIEKIRPLAEPYGICRIIPPSTWKPPCRLKEKSIWEQTKFPTRIQTVDLLQNREPMKKKPKSRKRKRRRNSRMGSSKRRSGSSPAESTSSPEAEEKFGFNSGSDFTLDEFEKYALHFKDSYFEKKDSGGDIVKWTPSVDDIEGEYWRIVEQPTDEVEVYYGADLENGVLGSGFYKRAEKFTGSDMEQYTLSGWNLNNLPRLPGSVLSFEDCDISGVLVPWLYVGMCFSSFCWHVEDHHLYSLNYHHFGEPKVWYGVPGSNATALEKAMRKHLPDLFEEQPDLLHGLVTQFSPSILKDEGVQAYRVVQNSGEYVLTFPRAYHAGFNCGFNCAEAVNVAPVDWLAHGQNAVELYSKETRKTSLSHDKLLLGAAYEAVKALWELSASEGKENTTNLRWKSFCGKNGTLTNAIQARLQMEEGRITALGRDSSSLKKMEKDFDSNCERECFSCFYDLHLSASGCKCSPEEYACLKHADDLCSCDVKDGFILLRYTMDELSSLVRALEGESDDLKIWASKVLGIEHSDEDQTKTSSVISEEKKLKEGSFDLNIDLEMDYQEDVKEEASTSGGELTASENLGVSVEPINLGFLIFGKLWCNKYAIFPKGFRSRVKFYNVLDPTRMSNYISEVLDAGLMGPLFRVTLEESPDESFFNVSAQQCWEMVMRRVKDTSTSLGLPILPQFESINGLQMFGFLSPSIVQAIEALDPNHRLVEYWNHKNQTSSDSKDHFISSNCSASLTKGKLFGVDLM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Phosphorylation	DTIMEQPSSPRHRKV CCCCCCCCCHHHHHH		19880383
36	Phosphorylation	TIMEQPSSPRHRKVV CCCCCCCCHHHHHHH		19880383
595	Phosphorylation	KVLGIEHSDEDQTKT HHHCCCCCCCCCCHH		25561503
602	Phosphorylation	SDEDQTKTSSVISEE CCCCCCHHCCCCCCH		25561503
603	Phosphorylation	DEDQTKTSSVISEEK CCCCCHHCCCCCCHH		25561503
604	Phosphorylation	EDQTKTSSVISEEKK CCCCHHCCCCCCHHH		25561503
607	Phosphorylation	TKTSSVISEEKKLKE CHHCCCCCCHHHHCC		23111157

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of JMJ18_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of JMJ18_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of JMJ18_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of JMJ18_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.