JAML_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: JAML_HUMAN
• UniProt AC: Q86YT9
• Protein Name: Junctional adhesion molecule-like {ECO:0000312|HGNC:HGNC:19084}
• Gene Name: JAML {ECO:0000312|HGNC:HGNC:19084}
• Organism: Homo sapiens (Human).
• Sequence Length: 394
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Cell junction . Localized at the plasma membrane and enriched in areas of cell-cell contacts (PubMed:12869515).
• Protein Description: Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR..
• Protein Sequence: MFCPLKLILLPVLLDYSLGLNDLNVSPPELTVHVGDSALMGCVFQSTEDKCIFKIDWTLSPGEHAKDEYVLYYYSNLSVPIGRFQNRVHLMGDILCNDGSLLLQDVQEADQGTYICEIRLKGESQVFKKAVVLHVLPEEPKELMVHVGGLIQMGCVFQSTEVKHVTKVEWIFSGRRAKEEIVFRYYHKLRMSVEYSQSWGHFQNRVNLVGDIFRNDGSIMLQGVRESDGGNYTCSIHLGNLVFKKTIVLHVSPEEPRTLVTPAALRPLVLGGNQLVIIVGIVCATILLLPVLILIVKKTCGNKSSVNSTVLVKNTKKTNPEIKEKPCHFERCEGEKHIYSPIIVREVIEEEEPSEKSEATYMTMHPVWPSLRSDRNNSLEKKSGGGMPKTQQAF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
69	Phosphorylation	GEHAKDEYVLYYYSN CCCCCCEEEEEEEEC		7453189
73	Phosphorylation	KDEYVLYYYSNLSVP CCEEEEEEEECCCCC		7453399
74	Phosphorylation	DEYVLYYYSNLSVPI CEEEEEEEECCCCCC		7453409
76	N-linked_Glycosylation	YVLYYYSNLSVPIGR EEEEEEECCCCCCCC		UniProtKB CARBOHYD
173	Phosphorylation	TKVEWIFSGRRAKEE EEEEEEEECCCCCHH		24719451
196	O-linked_Glycosylation	LRMSVEYSQSWGHFQ HHEEEEEHHHCCCHH		OGP
198	Phosphorylation	MSVEYSQSWGHFQNR EEEEEHHHCCCHHCC		68729291
231	N-linked_Glycosylation	VRESDGGNYTCSIHL EEECCCCCEEEEEEE		UniProtKB CARBOHYD
233	Phosphorylation	ESDGGNYTCSIHLGN ECCCCCEEEEEEECC		27251275
235	Phosphorylation	DGGNYTCSIHLGNLV CCCCEEEEEEECCEE		27251275
339	Phosphorylation	CEGEKHIYSPIIVRE CCCCCEECCCEEEEE		8225183
340	Phosphorylation	EGEKHIYSPIIVREV CCCCEECCCEEEEEE		28450419
354	Phosphorylation	VIEEEEPSEKSEATY ECCCCCCCCCCCCEE		29978859
357	Phosphorylation	EEEPSEKSEATYMTM CCCCCCCCCCEEEEC		22210691
360	Phosphorylation	PSEKSEATYMTMHPV CCCCCCCEEEECCCC		29978859
361	Phosphorylation	SEKSEATYMTMHPVW CCCCCCEEEECCCCC		29978859
363	Phosphorylation	KSEATYMTMHPVWPS CCCCEEEECCCCCHH		29978859
370	Phosphorylation	TMHPVWPSLRSDRNN ECCCCCHHHHCCCCC		22210691
381	Acetylation	DRNNSLEKKSGGGMP CCCCCCCCCCCCCCC		22361549

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of JAML_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of JAML_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of JAML_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of JAML_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.