JAC1_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: JAC1_CAEEL
• UniProt AC: Q9U308
• Protein Name: Juxtamembrane domain-associated catenin
• Gene Name: jac-1
• Organism: Caenorhabditis elegans.
• Sequence Length: 1254
• Subcellular Localization: Cell junction, adherens junction . Nucleus .
• Protein Description: May act as a positive modulator of hmr-1 function during epidermal morphogenesis. [PubMed: 12847081 Required for proper localization of other junctional components, such as pac-1]
• Protein Sequence: MISSGWMQEMEPIPEEGTEADGSEWGAMSDTAKRTMRKKEVYTSEQINTLVSTVPKEAVPQEWLVENQVVDPEMATSYLTESLAGPTSARGSSYSYSYESHYDNPPEEEYEHFTNDDGVHQMQKVTRVTKVTTTRSVRQVPVQSPYSNIDFDSSGLPTPSPVIDRDPSLEMMARMGGASDHDSEDRSAPPPAPASRFLHEDSGIPSAPGVPDVVDAGIGEVTVVWSAPLQSNGGEVRGYQIEMREFPDGEWESMGVDHLLKDTTCRVTNLTSHEVQFRVSAYGRTGFGPASNPSLPVKIPISETDLATSAGAPLAPGRPTVIAVDGQGVLLEWTPPVADVHSSPPQGYQVEYRVYGSRDWIVANEQLVQENVFTVESLRPNGVYEFRVRGKNQDGLGHPSMSSGGVAIRPAAPQRHVPARKVSESVQPPGQPQMVEVGDDVVKLEWAPSVQNARYIVEYREVGDPEWHTANYDPIVQNGIQVEGLHRNSTYEFCVISIVDNIASQPSETSDIIHLRPTCNTSALRPAPNILEAPEFLEVDGDKITICWLPAQSQLPVMGYDVEFRDLQQDDRWYKVNDQPVFACKMTVGDLIMDHDYQFRVLAHNASGCSQPSPPSDFVHIEPSTNRFSSDTMESPHLGHHDVVKYVEAERFGAVPLLQEEMVRESPPLPERDDSPPPLRRANNNVQWRDPSLKEVIEYLSSADKDKQLNASGYLQHLTYTDNQIKEETREYGGIPKLIALLRSDTPRIQKNACACLKNLSFGKENDANKLAVMEADGVRLIAEVLRTTHDASVKEEAAAALWNLSSADMLKPVILESATEILSQQVIAPVLAVGTSDPTRHFGSTLFKNSTGVLRNVSAASQQARRRLRDIPNLIEALVHFLTHAIQKSQVDSPTVENAVCLLRNLSYRIQEVVDPNYDPAAAHSSSSKNMKHVASPKPEKKKKDKEKKKDKNPKNIVTGPSVLWQPHVVKLYLKLLQDSSNIETLEASAGAIQNLAACQFPPSAEVRAAVRVEKGLPVLVELIRLPEDFVVCAVATALRNLAIDPRNRELIGKYALRDFLDKLPEPGSPRRSAISDQTIGAVLGILFEIVRSSAAYTKDVHELKGTDKLRALSRSYPTYSHRVCKYASQVLYVMWQHKELHDGFKRSGLKEADFYSGTARRGDSSTLARPISSQGRERPSMHQLDETLSSGGGYGTMESNNRAGTLRPASATSQTIQRRYDQVPRDGPVYSSVQKPSPRGGGGGGNIDDSWV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
423	Phosphorylation	HVPARKVSESVQPPG CCCCCCCCCCCCCCC	27.47	19060867
425	Phosphorylation	PARKVSESVQPPGQP CCCCCCCCCCCCCCC	20.67	18806794
629	Phosphorylation	EPSTNRFSSDTMESP ECCCCCCCCCCCCCC	24.86	19530675
630	Phosphorylation	PSTNRFSSDTMESPH CCCCCCCCCCCCCCC	34.10	19530675
632	Phosphorylation	TNRFSSDTMESPHLG CCCCCCCCCCCCCCC	25.45	18806794
635	Phosphorylation	FSSDTMESPHLGHHD CCCCCCCCCCCCCCC	13.54	19530675
666	Phosphorylation	QEEMVRESPPLPERD HHHHHHCCCCCCCCC	22.66	21082442
675	Phosphorylation	PLPERDDSPPPLRRA CCCCCCCCCCCCCCC	43.53	28854356
937	Phosphorylation	KNMKHVASPKPEKKK CCCCCCCCCCHHHHH	32.16	28854356
1070	Phosphorylation	DKLPEPGSPRRSAIS HHCCCCCCCCCCCCC	26.42	28854356
1196	Phosphorylation	TLSSGGGYGTMESNN HHHCCCCCCCCCCCC	16.82	27067626
1212	Phosphorylation	AGTLRPASATSQTIQ CCCCCCCCCCHHHHH	34.46	28854356
1214	Phosphorylation	TLRPASATSQTIQRR CCCCCCCCHHHHHHH	20.90	19060867
1215	Phosphorylation	LRPASATSQTIQRRY CCCCCCCHHHHHHHH	25.66	19060867
1217	Phosphorylation	PASATSQTIQRRYDQ CCCCCHHHHHHHHHC	20.88	19530675
1222	Phosphorylation	SQTIQRRYDQVPRDG HHHHHHHHHCCCCCC	16.96	27067626
1232	Phosphorylation	VPRDGPVYSSVQKPS CCCCCCCCCCCCCCC	9.81	27067626
1239	Phosphorylation	YSSVQKPSPRGGGGG CCCCCCCCCCCCCCC	33.97	19060867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of JAC1_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of JAC1_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of JAC1_CAEEL !!

Protein-Protein Interaction

Oops, there are no PPI records of JAC1_CAEEL !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.